Abstract

Obtaining sufficient contrast is an indispensable requirement for detecting early stage cancer using optical coherence tomography (OCT), an emerging diagnostic tool that detects abnormal lesions with micrometer resolutions in real time. PEGylated gold nanoparticles (Au NPs; 87 nm in diameter) were formulated in aqueous dissolvable microneedles (dMNs; 200 μm height) for efficient, precisely controlled, and convenient delivery of Au NPs into hamster oral tissue in vivo. The Au NPs were then further briefly dissipated by ultrasound (US). The results showed 33% and 20% increase in average optical scattering intensity (contrast level) in dysplastic and normal tissues, respectively, and pinpointed pathological structures of early stage oral cancer were also identified by the highly convenient and efficient administration of Au NPs in a novel delivery platform.

© 2010 OSA

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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    [CrossRef] [PubMed]
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2009 (1)

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

2008 (1)

2007 (2)

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

2006 (1)

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

2005 (2)

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

1997 (2)

1996 (1)

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

1995 (2)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

M. J. Yadlowsky, J. M. Schmitt, and R. F. Bonner, “Multiple scattering in optical coherence microscopy,” Appl. Opt. 34(25), 5699–5707 (1995).
[CrossRef]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

1973 (1)

G. Frens, “Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions,” Nat. Phys. Sci (Lond.) 241, 20–22 (1973).

Aaron, J.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Ahn, Y. C.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Aveyard, J.

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

Birngruber, R.

Bonner, R. F.

Boppart, S. A.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Bouma, B.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Bouma, B. E.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

Brezinski, M. E.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Chang, E. W.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chen, Z.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Chumakov, Y.

Coghlan, L.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Collier, T.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Curiel, D. T.

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

Denisenko, A.

Engelhardt, R.

Everts, M.

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

Feldchtein, F.

Fernig, D. G.

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Follen, M.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Frens, G.

G. Frens, “Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions,” Nat. Phys. Sci (Lond.) 241, 20–22 (1973).

Fujimoto, J. G.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Gelikonov, G.

Gelikonov, V.

Gladkova, N.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Haiss, W.

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

Hee, M. R.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hirano, T.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Ikeda, N.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Izatt, J. A.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

José-Yacamán, M.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Kato, H.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Kim, C. S.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Kim, J. W.

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

Kumar, S.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Kuranov, R.

Kuznetzova, I.

Kwon, Y. J.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Liaw, L. H.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Marks, D. L.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

Nagatsuka, Y.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Nitin, N.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Ohira, T.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Oldenburg, A. L.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

Pan, Y. T.

Park, S. Y.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Pochinko, V.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Richards-Kortum, R.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Schmitt, J. M.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sergeev, A.

Shakhov, A.

Shakhova, N.

Sharma, U.

Snopova, L.

Sokolov, K.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Southern, J. F.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Streltzova, O.

Suga, Y.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Swanson, E. A.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Thanh, N. T.

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

Travis, K.

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Tsuboi, M.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Usuda, J.

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

Wilder-Smith, P.

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

Xu, C.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

Yadlowsky, M. J.

Yun, S. H.

Zharov, V. P.

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

Anal. Chem. (1)

W. Haiss, N. T. Thanh, J. Aveyard, and D. G. Fernig, “Determination of size and concentration of gold nanoparticles from UV-vis spectra,” Anal. Chem. 79(11), 4215–4221 (2007).
[CrossRef] [PubMed]

Appl. Opt. (2)

Circulation (1)

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, “Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology,” Circulation 93(6), 1206–1213 (1996).
[PubMed]

Int. J. Clin. Oncol. (1)

T. Ohira, Y. Suga, Y. Nagatsuka, J. Usuda, M. Tsuboi, T. Hirano, N. Ikeda, and H. Kato, “Early-stage lung cancer: diagnosis and treatment,” Int. J. Clin. Oncol. 11(1), 9–12 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt. (3)

C. S. Kim, P. Wilder-Smith, Y. C. Ahn, L. H. Liaw, Z. Chen, and Y. J. Kwon, “Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles,” J. Biomed. Opt. 14(3), 034008 (2009).
[CrossRef] [PubMed]

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10(4), 041208 (2005).
[CrossRef] [PubMed]

J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. José-Yacamán, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, “Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo,” J. Biomed. Opt. 12(3), 034007 (2007).
[CrossRef] [PubMed]

Nanomedicine (1)

V. P. Zharov, J. W. Kim, D. T. Curiel, and M. Everts, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy,” Nanomedicine 1(4), 326–345 (2005).
[PubMed]

Nat. Med. (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[CrossRef] [PubMed]

Nat. Phys. Sci (Lond.) (1)

G. Frens, “Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions,” Nat. Phys. Sci (Lond.) 241, 20–22 (1973).

Opt. Express (2)

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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Figures (8)

Fig. 1
Fig. 1

Au NP-containing dissolvable microneedles (dMNs) arrayed on a dissolvable disc (1 cm in diameter).

Fig. 2
Fig. 2

DMBA-treated hamster cheek pouch attached to a microscope stage using a custom-built, ring-shaped clamp (1 cm in diameter).

Fig. 3
Fig. 3

Schematic of optical fiber-based spectral-domain (SD)-OCT system: AL, aiming laser; CM, collimator; DAQ, data acquisition system; DG, diffraction grating; FL, focusing lens; LCL, low-coherence light; LSC, line scan camera.

Fig. 4
Fig. 4

Au NPs containing dissolvable microneedles (200 μm height).

Fig. 5
Fig. 5

Average SD-OCT signal (scattering intensity) from normal and dysplastic hamster oral tissues before and after dMN and US application.

Fig. 6
Fig. 6

SD-OCT images of in vivo oral dysplasia and normal tissues. (a) Dysplastic tissue before application of dMNs and US, (b) dysplastic tissue after both dMNs and US were applied, (c) normal tissue before dMNs and US were applied, (d) normal tissue after both dMNs and US were applied. Yellow areas were quantitatively analyzed for OCT signal intensity in Fig. 7.

Fig. 7
Fig. 7

Depth-dependent SD-OCT signal intensity profiles in dysplastic and normal hamster cheek pouch tissues. Yellow area: stratum corneum (SC); green area: epithelial layer; blue area: disrupted epithelial layer in dysplastic tissue.

Fig. 8
Fig. 8

H&E stained dysplastic and normal hamster cheek pouch tissues.

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