Abstract

Fluorescence imaging is well suited to provide image guidance during resections in oncologic and vascular surgery. However, the distorting effects of tissue optical properties on the emitted fluorescence are poorly compensated for on even the most advanced fluorescence image guidance systems, leading to subjective and inaccurate estimates of tissue fluorophore concentrations. Here we present a novel fluorescence imaging technique that performs real-time (i.e., video rate) optical property corrected fluorescence imaging. We perform full field of view simultaneous imaging of tissue optical properties using Single Snapshot of Optical Properties (SSOP) and fluorescence detection. The estimated optical properties are used to correct the emitted fluorescence with a quantitative fluorescence model to provide quantitative fluorescence-Single Snapshot of Optical Properties (qF-SSOP) images with less than 5% error. The technique is rigorous, fast, and quantitative, enabling ease of integration into the surgical workflow with the potential to improve molecular guidance intraoperatively.

© 2017 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]

2016 (1)

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

2015 (2)

2014 (1)

B. Yang and J. W. Tunnell, “Real-time absorption reduced surface fluorescence imaging,” J. Biomed. Opt. 19(9), 090505 (2014).
[Crossref] [PubMed]

2013 (4)

J. Vervandier and S. Gioux, “Single snapshot imaging of optical properties,” Biomed. Opt. Express 4(12), 2938–2944 (2013).
[Crossref] [PubMed]

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

2012 (2)

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

2011 (5)

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

2010 (3)

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

2009 (2)

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

2006 (2)

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc. Interface 3(6), 1–13 (2006).
[Crossref] [PubMed]

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

2005 (1)

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

1996 (1)

Alyabyev, S.

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Angelo, J.

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

Angelo, J. P.

Arts, H. J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Ashitate, Y.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Bae, S.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Bart, J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Bigio, I. J.

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

Bradley, R. S.

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc. Interface 3(6), 1–13 (2006).
[Crossref] [PubMed]

Choi, H. S.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Crane, L. M.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Cuccia, D.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Cuccia, D. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

de Jong, J. S.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Dunham, J.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Durkin, A. J.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Durr, N. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Elliott, J. T.

Erickson, T. A.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Erkmen, K.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Fan, X.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Feith, D.

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Frangioni, J. V.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

Gardner, C. M.

Gibbs, S. L.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Gioux, S.

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

M. van de Giessen, J. P. Angelo, and S. Gioux, “Real-time, profile-corrected single snapshot imaging of optical properties,” Biomed. Opt. Express 6(10), 4051–4062 (2015).
[Crossref] [PubMed]

J. Vervandier and S. Gioux, “Single snapshot imaging of optical properties,” Biomed. Opt. Express 4(12), 2938–2944 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

Harlaar, N. J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Harris, B. T.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Hartov, A.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Henary, M.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Hyun, H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Jacobs, V. L.

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

Jacques, S. L.

Ji, S.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Kelder, W.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Kelly, E.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Kelly, K. M.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Khurana, M.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Kim, A.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Kim, S. H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Kolste, K.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Konecky, S. D.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Leblond, F.

M. Sibai, I. Veilleux, J. T. Elliott, F. Leblond, and B. C. Wilson, “Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection,” Biomed. Opt. Express 6(12), 4923–4933 (2015).
[Crossref] [PubMed]

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Lee, B. T.

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Lee, J. H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Lin, S. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Liu, F.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Low, P. S.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Mazhar, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Meinel, T.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Moffitt, L. A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Moriyama, Y.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Nasr, K.

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Ntziachristos, V.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Oketokoun, R.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Owen, C. M.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Park, G.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Patonay, G.

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Paulsen, K. D.

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Pichlmeier, U.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Pleijhuis, R. G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Reulen, H. J.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Rice, T.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Ripoll, J.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Roberts, D. W.

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Saager, R. B.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Saggese, S.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Sarantopoulos, A.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Schulz, R.

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

Sharma, M.

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

Shih, H. A.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Sibai, M.

Simmons, N. E.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Soh, K. S.

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

Soubret, A.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Stockdale, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Strekowski, L.

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Stummer, W.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Themelis, G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

Thorniley, M. S.

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc. Interface 3(6), 1–13 (2006).
[Crossref] [PubMed]

Tobias, A. M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Tosteson, T. D.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Tromberg, B. J.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Tunnell, J. W.

B. Yang and J. W. Tunnell, “Real-time absorption reduced surface fluorescence imaging,” J. Biomed. Opt. 19(9), 090505 (2014).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Turner, G.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Valdes, P. A.

Valdés, P. A.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

van Dam, G. M.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

van de Giessen, M.

van der Zee, A. G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Vargas, C. R.

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

Veilleux, I.

Vervandier, J.

Weinmann, M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Welch, A. J.

Wiestler, O. D.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Wilson, B. C.

M. Sibai, I. Veilleux, J. T. Elliott, F. Leblond, and B. C. Wilson, “Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection,” Biomed. Opt. Express 6(12), 4923–4933 (2015).
[Crossref] [PubMed]

P. A. Valdes, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Windsor, S.

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

Xie, Y.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Yang, B.

B. Yang and J. W. Tunnell, “Real-time absorption reduced surface fluorescence imaging,” J. Biomed. Opt. 19(9), 090505 (2014).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

Yoo, J. S.

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

Zanella, F.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Angew. Chem. Int. Ed. Engl. (1)

H. S. Choi, K. Nasr, S. Alyabyev, D. Feith, J. H. Lee, S. H. Kim, Y. Ashitate, H. Hyun, G. Patonay, L. Strekowski, M. Henary, and J. V. Frangioni, “Synthesis and in vivo fate of zwitterionic near-infrared fluorophores,” Angew. Chem. Int. Ed. Engl. 50(28), 6258–6263 (2011).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (3)

J. Biomed. Opt. (12)

J. Angelo, C. R. Vargas, B. T. Lee, I. J. Bigio, and S. Gioux, “Ultrafast optical property map generation using lookup tables,” J. Biomed. Opt. 21(11), 110501 (2016).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

V. Ntziachristos, G. Turner, J. Dunham, S. Windsor, A. Soubret, J. Ripoll, and H. A. Shih, “Planar fluorescence imaging using normalized data,” J. Biomed. Opt. 10(6), 064007 (2005).
[Crossref] [PubMed]

G. Themelis, J. S. Yoo, K. S. Soh, R. Schulz, and V. Ntziachristos, “Real-time intraoperative fluorescence imaging system using light-absorption correction,” J. Biomed. Opt. 14(6), 064012 (2009).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

B. Yang and J. W. Tunnell, “Real-time absorption reduced surface fluorescence imaging,” J. Biomed. Opt. 19(9), 090505 (2014).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. Mazhar, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging,” J. Biomed. Opt. 15(1), 010506 (2010).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

J. Neurosurg. (1)

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

J. R. Soc. Interface (1)

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc. Interface 3(6), 1–13 (2006).
[Crossref] [PubMed]

Lancet Oncol. (1)

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31(2), 148–153 (2013).
[Crossref] [PubMed]

Nat. Med. (1)

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Opt. Lett. (1)

Sci. Rep. (1)

P. A. Valdés, F. Leblond, V. L. Jacobs, B. C. Wilson, K. D. Paulsen, and D. W. Roberts, “Quantitative, spectrally-resolved intraoperative fluorescence imaging,” Sci. Rep. 2, 798 (2012).
[Crossref] [PubMed]

Supplementary Material (1)

NameDescription
» Visualization 1       qF-SSOP Movie

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Figures (4)

Fig. 1
Fig. 1

qF-SSOP Imaging Schematics. An imaging system for dual SSOP reflectance and fluorescence imaging similar to previous work [20] was specifically developed. A) Three temporally and spatially simultaneous images are acquired in real time: one fluorescence (λ>815 nm) and two reflectance images at the excitation (λx = 760 nm) and emission wavelengths (λm = 808 nm) under SSOP mode. B) The reflectance images at λx and λm at one spatial frequency are processed under SSOP conditions to derive the diffuse reflectance and corresponding μa and μs’ maps. Fluorescence is evaluated using either the raw fluorescence maps only (Fx,m) or an attenuation correction is applied unto the raw fluorescence Fx,m to compensate for the distorting effects of tissue optical properties to derive qF-SSOP fluorescence maps (fx,m = Fx,m/X)

Fig. 2
Fig. 2

Raw, F/R and qF-SSOP fluorescence using Eq. (2). Tissue simulation phantoms with equal fluorophore concentrations (5 μM) demonstrate a clear difference in the A) raw fluorescence with attenuating effects with increasing absorption (top to bottom) and increasing scattering (left to right); B) demonstrates the F/R empiric fluorescence following an empiric correction using the raw reflectance in the same phantoms with a moderate improvement in the estimated fluorescence across all tissue phantoms; whereas C) demonstrates qF-SSOP imaging following a model based correction for tissue optical properties in the same phantoms with a notable similarity in the estimated fluorescence across all tissue phantoms. Note: all methods were scaled to the same values of fluorescence, though qF-SSOP enables units of concentration.

Fig. 3
Fig. 3

Region of interest analysis of raw fluorescence, F/R, and qF-SSOP. Estimated fluorophore concentrations using A) raw fluorescence demonstrate a significant deviation from the true phantom concentration (dotted red line) of 5µM compared to B) F/R, and C) qF-SSOP as demonstrated by the mean percentage error (mPE) estimates of 43.0%, 21.6% and 4.8%, respectively.

Fig. 4
Fig. 4

Real-time dynamic video of two tissue simulating phantoms (see Visualization 1). Two tissue simulating phantoms of varying tisue optical properties are imaged in real time with A) showing the raw fluorescence, B) the F/R fluorescence,and C) the qF-SSOP fluorescence of the same phantoms following correction for tissue optical properties. Note, only the qF-SSOP fluorescence imaging presents a quantitative scale in fluorophore concentration. Scale bar = 1cm

Tables (1)

Tables Icon

Table 1 Phantom Optical Properties (mm−1)

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

f xm = F xm X
f xm = μ a,x ( 1 R x ) * F xm R m