Abstract

The dosimetry of light-based therapies critically depends on both optical and vascular parameters. We utilized spatial frequency domain imaging to quantify optical and vascular parameters, as well as estimated light penetration depth from 17 nonmelanoma skin cancer patients. Our data indicates that there exist substantial spatial variations in these parameters. Characterization of these parameters may inform understanding and optimization of the clinical response of light-based therapies.

© 2015 Optical Society of America

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  1. A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
    [Crossref] [PubMed]
  2. L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
    [Crossref] [PubMed]
  3. L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
    [Crossref] [PubMed]
  4. E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
    [PubMed]
  5. U. Sunar, D. Rohrbach, N. Rigual, E. Tracy, K. Keymel, M. T. Cooper, H. Baumann, and B. H. Henderson, “Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report,” Opt. Express 18(14), 14969–14978 (2010).
    [Crossref] [PubMed]
  6. D. J. Rohrbach, N. Rigual, E. Tracy, A. Kowalczewski, K. L. Keymel, M. T. Cooper, W. Mo, H. Baumann, B. W. Henderson, and U. Sunar, “Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies,” Biomed. Opt. Express 3(9), 2142–2153 (2012).
    [Crossref] [PubMed]
  7. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
    [Crossref] [PubMed]
  8. T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
    [PubMed]
  9. D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
    [Crossref] [PubMed]
  10. B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
    [Crossref] [PubMed]
  11. R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
    [Crossref] [PubMed]
  12. B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
    [Crossref] [PubMed]

2014 (1)

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

2013 (1)

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

2012 (2)

2011 (1)

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

2010 (1)

2009 (2)

A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

2007 (1)

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

2004 (2)

E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
[PubMed]

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

2000 (1)

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Anolik, R.

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

Anstey, A.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Bachmann, I.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Baumann, H.

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Brightman, L.

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

Busch, T. M.

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Butler, J.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Casey, A. S.

A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
[Crossref] [PubMed]

Cerussi, A.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Cerussi, A. E.

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

Cheney, R. T.

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Cooper, M. T.

Cuccia, D. J.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

de Rie, M. A.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Durkin, A. J.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Espinoza, J.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Geronemus, R.

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

Goldberg, D. J.

E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
[PubMed]

Goldman, G. D.

A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
[Crossref] [PubMed]

Gollnick, S. O.

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Goulden, V.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Henderson, B. H.

Henderson, B. W.

D. J. Rohrbach, N. Rigual, E. Tracy, A. Kowalczewski, K. L. Keymel, M. T. Cooper, W. Mo, H. Baumann, B. W. Henderson, and U. Sunar, “Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies,” Biomed. Opt. Express 3(9), 2142–2153 (2012).
[Crossref] [PubMed]

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Huihui, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Kelly, K. M.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

Kennedy, C. E.

A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
[Crossref] [PubMed]

Keymel, K.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

U. Sunar, D. Rohrbach, N. Rigual, E. Tracy, K. Keymel, M. T. Cooper, H. Baumann, and B. H. Henderson, “Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report,” Opt. Express 18(14), 14969–14978 (2010).
[Crossref] [PubMed]

Keymel, K. L.

Kousis, P. C.

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Kowalczewski, A.

Lanning, R.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Leifsdottir, R.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Marmur, E. S.

E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
[PubMed]

Mo, W.

Morgan, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Muffoletto, D.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

O’Sullivan, T. D.

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

Paquette, A.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Pham, T.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Rhodes, L. E.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Richard, M. A.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Rigual, N.

Rohrbach, D.

Rohrbach, D. J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

D. J. Rohrbach, N. Rigual, E. Tracy, A. Kowalczewski, K. L. Keymel, M. T. Cooper, W. Mo, H. Baumann, B. W. Henderson, and U. Sunar, “Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies,” Biomed. Opt. Express 3(9), 2142–2153 (2012).
[Crossref] [PubMed]

Saager, R.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R. B.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

Saggese, S.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

Schmults, C. D.

E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
[PubMed]

Shah, N.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Snyder, J. W.

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Sunar, U.

Svaasand, L.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Tracy, E.

Tromberg, B. J.

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Warycha, M.

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

Wolf, P.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Wong, G. A.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Yu, R. C.

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Zeitouni, N.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Acad. Radiol. (1)

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Arch. Dermatol. (1)

L. E. Rhodes, M. A. de Rie, R. Leifsdottir, R. C. Yu, I. Bachmann, V. Goulden, G. A. Wong, M. A. Richard, A. Anstey, and P. Wolf, “Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma,” Arch. Dermatol. 143(9), 1131–1136 (2007).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Cancer Res. (1)

B. W. Henderson, S. O. Gollnick, J. W. Snyder, T. M. Busch, P. C. Kousis, R. T. Cheney, and J. Morgan, “Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors,” Cancer Res. 64(6), 2120–2126 (2004).
[Crossref] [PubMed]

Dermatol. Surg. (2)

A. S. Casey, C. E. Kennedy, and G. D. Goldman, “Mohs micrographic surgery: How ACMS fellowship directors practice,” Dermatol. Surg. 35(5), 747–756 (2009).
[Crossref] [PubMed]

E. S. Marmur, C. D. Schmults, and D. J. Goldberg, “A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer,” Dermatol. Surg. 30(2 Pt 2), 264–271 (2004).
[PubMed]

J. Biomed. Opt. (2)

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

Lasers Surg. Med. (1)

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “A light emitting diode (LED) based spatial frequency domain imaging system for optimization of photodynamic therapy of nonmelanoma skin cancer: quantitative reflectance imaging,” Lasers Surg. Med. 45(4), 207–215 (2013).
[Crossref] [PubMed]

Neoplasia (1)

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Opt. Express (1)

Semin. Cutan. Med. Surg. (1)

L. Brightman, M. Warycha, R. Anolik, and R. Geronemus, “Do lasers or topicals really work for nonmelanoma skin cancers?” Semin. Cutan. Med. Surg. 30(1), 14–25 (2011).
[Crossref] [PubMed]

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Figures (4)

Fig. 1
Fig. 1 Schematic diagram of the clinical SFDI instrument showing the projector module, two CCD cameras, beam splitter, polarizer and analyzer.
Fig. 2
Fig. 2 A representative tumor contrast images from a patient with BCC. (a) Diffuse reflectance image. The solid black shape to the right is a motion-tracking sticker. The dashed line shows the subregion used for reconstruction of the parameters, with the lesion (dotted line) on the right and periphery on the left. (b) Absorption parameter map (c) Scattering parameter map (d) Tissue blood oxygen saturation map (e) Total hemoglobin concentration map (f) Optical penetration depth map. The black bar in the lower right corner of each figure is 2 mm and the dotted line shows the tumor ROI.
Fig. 3
Fig. 3 Histograms of (a) absorption (µa) and (b) scattering (µs) and (c) penetration depth (δ) parameters at 590nm, 630nm and 740nm for all patients.
Fig. 4
Fig. 4 Histograms of tissue oxygen saturation (StO2) and total hemoglobin concentration (THC) for all patients.

Tables (1)

Tables Icon

Table 1 Pretreatment values of all reconstructed parameters by SFDI for all patients.

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