Abstract

A novel lens-array based illumination design for a compact co-registered photoacoustic/ultrasound transvaginal probe has been demonstrated. The lens array consists of four cylindrical lenses that couple the laser beams into four 1-mm-core multi-mode optical fibers with optical coupling efficiency of ~87%. The feasibility of our lens array was investigated by simulating the lenses and laser beam profiles using Zemax. The laser fluence on the tissue surface was experimentally measured and was below the American National Standards Institute (ANSI) safety limit. Spatial distribution of hemoglobin oxygen saturation (sO2) of a mouse tumor was obtained in vivo using photoacoustic measurements at multiple wavelengths. Furthermore, benign and malignant ovaries were imaged ex vivo and evaluated histologically. The co-registered images clearly showed different patterns of blood vasculature. These results highlight the clinical potential of our system for noninvasive photoacoustic and ultrasound imaging of ovarian tissue and cancer detection and diagnosis.

© 2014 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. L. Clarke-Pearson, “Clinical practice. screening for ovarian cancer,” N. Engl. J. Med.361(2), 170–177 (2009).
    [CrossRef] [PubMed]
  2. D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
    [CrossRef] [PubMed]
  3. M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
    [PubMed]
  4. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
    [CrossRef] [PubMed]
  5. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
    [CrossRef] [PubMed]
  6. S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
    [CrossRef] [PubMed]
  7. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
    [CrossRef] [PubMed]
  8. A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
    [CrossRef] [PubMed]
  9. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
    [CrossRef]
  10. J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
    [CrossRef] [PubMed]
  11. R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
    [CrossRef] [PubMed]
  12. J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
    [CrossRef] [PubMed]
  13. T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
    [CrossRef] [PubMed]
  14. G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
    [CrossRef] [PubMed]
  15. P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
    [CrossRef] [PubMed]
  16. U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).
  17. U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.
  18. H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
    [CrossRef]
  19. American National Standard for the Safe Use of Lasers, ANSI Z136 (Laser Institute of America, Orlando, Florida, 2007), pp. 1–2007.

2014

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

2013

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

2012

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

2011

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

2009

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

D. L. Clarke-Pearson, “Clinical practice. screening for ovarian cancer,” N. Engl. J. Med.361(2), 170–177 (2009).
[CrossRef] [PubMed]

2008

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

2005

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

2004

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

2003

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

2000

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

Aguirre, A.

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Alqasemi, U.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Amirian, J. H.

Ardeshirpour, Y.

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

Barton, J. K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Beard, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Blank, S. V.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Bozorgi, K.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Brands, W. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Brewer, M.

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

Brewer, M. A.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Castillo, D.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Clarke-Pearson, D. L.

D. L. Clarke-Pearson, “Clinical practice. screening for ovarian cancer,” N. Engl. J. Med.361(2), 170–177 (2009).
[CrossRef] [PubMed]

Cohen, L.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Cox, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Davis, J. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Emelianov, S. Y.

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Fishman, D. A.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Gamelin, J.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Gmitro, A. F.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Hoying, J. B.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Huang, F.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Hunt, K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Johnson, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Karabutov, A.

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Kirkpatrick, N. D.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Kiser, W. L.

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

Kruger, G. A.

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

Kruger, R. A.

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

Ku, G.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Kumavor, P. D.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
[CrossRef] [PubMed]

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Laufer, J.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Li, H.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Litovsky, S. H.

Maurudis, A.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Pedley, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Podymova, N. B.

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

Reinecke, D. R.

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

Salehi, H. S.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

Sanders, M. M.

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

Savateeva, E. V.

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

Schwartz, P. E.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Sethuraman, S.

Shulman, L.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Singh, D.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Smalling, R. W.

Stevens, S. J.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Stoica, G.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Sun, X.

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

Tamura, R.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Tavakoli, B.

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

Timor-Tritsch, I.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

Treeby, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Utzinger, U.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Wang, L. V.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Wang, T.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
[CrossRef] [PubMed]

Wang, X.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Warych, E.

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Yang, Y.

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

Yuan, G.

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Zanganeh, S.

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Zhang, E.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Zhu, Q.

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
[CrossRef] [PubMed]

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

Am. J. Obstet. Gynecol.

D. A. Fishman, L. Cohen, S. V. Blank, L. Shulman, D. Singh, K. Bozorgi, R. Tamura, I. Timor-Tritsch, and P. E. Schwartz, “The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer,” Am. J. Obstet. Gynecol.192(4), 1214–1221 (2005).
[CrossRef] [PubMed]

IEEE Trans. Ultrason., Ferr. Freq. Control

U. Alqasemi, H. Li, A. Aguirre, and Q. Zhu, “FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging,” IEEE Trans. Ultrason., Ferr. Freq. Control59(7), 1344–1353 (2012).

J. Appl. Phys.

A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000).
[CrossRef]

J. Biomed. Opt.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012).
[CrossRef] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009).
[CrossRef] [PubMed]

J. Biophotonics

P. D. Kumavor, U. Alqasemi, B. Tavakoli, H. Li, Y. Yang, X. Sun, E. Warych, and Q. Zhu, “Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue,” J. Biophotonics6(6-7), 475–484 (2013).
[CrossRef] [PubMed]

Med. Phys.

R. A. Kruger, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography using a conventional linear transducer array,” Med. Phys.30(5), 856–860 (2003).
[CrossRef] [PubMed]

N. Engl. J. Med.

D. L. Clarke-Pearson, “Clinical practice. screening for ovarian cancer,” N. Engl. J. Med.361(2), 170–177 (2009).
[CrossRef] [PubMed]

Nat. Biotechnol.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Opt. Express

Phys. Med. Biol.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol.49(7), 1329–1338 (2004).
[CrossRef] [PubMed]

Proc. SPIE

H. S. Salehi, P. D. Kumavor, U. Alqasemi, H. Li, T. Wang, and Q. Zhu, “High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging,” Proc. SPIE8943, 894335 (2014).
[CrossRef]

Science

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Technol. Cancer Res. Treat.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Trans. Oncol.

A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization,” Trans. Oncol.4(1), 29–37 (2011).
[CrossRef] [PubMed]

Other

U. Alqasemi, H. Li, G. Yuan, P. D. Kumavor, S. Zanganeh, and Q. Zhu, “Real-time interlaced ultrasound and photoacoustic system for in vivo ovarian tissue imaging,” J. Biomed. Opt.in press.

American National Standard for the Safe Use of Lasers, ANSI Z136 (Laser Institute of America, Orlando, Florida, 2007), pp. 1–2007.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (6)

Fig. 1
Fig. 1

(a) Experimental setup for ex vivo co-registered photoacoustic/ultrasound imaging. (b) Normalized laser output energy measured with single element ultrasound transducer and energy meter.

Fig. 2
Fig. 2

(a) Simulated laser beam profile at 40mm away from the lens array, (b) 120mm away from the lens array, (c) 140mm away from the lens array. (d) Photograph of the designed lens array and experimental validation at ~40mm away from the lens array, (e) experimental validation at ~120mm, and (f) experimental validation at ~140mm. (g) Illumination setup before miniaturization, (h) after miniaturization.

Fig. 3
Fig. 3

(a) Simulated laser beam profile after propagating through the optical fiber. (b) The corresponding one-dimensional profile of the beam.

Fig. 4
Fig. 4

In vivo co-registered photoacoustic/ultrasound images of the tumor area at wavelength of (a) 750nm, (b) 800nm, and (c) 840nm. (d) The co-registered ultrasound and oxygen saturation (sO2) image obtained from PAT acquisitions at 14 different wavelengths.

Fig. 5
Fig. 5

(a) Ex vivo co-registered photoacoustic/ultrasound image of premenopausal ovary with benign tissue; (b) H&E staining of the corresponding area ( × 1); (c) Reveals microvessels around the follicles ( × 40) from the rectangular region indicated in (b).

Fig. 6
Fig. 6

(a) Ex vivo co-registered photoacoustic/ultrasound image of postmenopausal ovary with malignancy. (b) Reveals a cluster of microvessels ( × 40) from the rectangular region indicated in (a).

Metrics