Abstract

A spectral domain optical coherence tomography (SD-OCT) system and an oral imaging probe have been developed to visualize the microstructural morphology and microvasculature in the human oral cavity. Structural OCT images of ex vivo pig oral tissues with the histology of the same sites were acquired and compared for correlations. Structural in vivo OCT images of healthy human tissue as well as a pathologic site (ulcer) were obtained and analyzed based on the results of the ex vivo pig study, drawing on the similarity between human and swine oral tissues. In vivo Doppler and speckle variance OCT images of the oral cavity in human volunteers were also acquired, to demonstrate the feasibility of microvascular imaging of healthy and pathologic (scar) oral tissue.

© 2012 OSA

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2011 (4)

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

K. Bizheva, N. Hutchings, L. Sorbara, A. A. Moayed, and T. Simpson, “In vivo volumetric imaging of the human corneo-scleral limbus with spectral domain OCT,” Biomed. Opt. Express2(7), 1794–02 (2011).
[CrossRef] [PubMed]

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

2010 (2)

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

A. Mariampillai, M. K. K. Leung, M. Jarvi, B. A. Standish, K. Lee, B. C. Wilson, A. Vitkin, and V. X. D. Yang, “Optimized speckle variance OCT imaging of microvasculature,” Opt. Lett.35(8), 1257–1259 (2010).
[CrossRef] [PubMed]

2009 (5)

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

2008 (3)

2007 (2)

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

2006 (3)

J. J. Sciubba and D. Goldenberg, “Oral complications of radiotherapy,” Lancet Oncol.7(2), 175–183 (2006).
[CrossRef] [PubMed]

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

2005 (3)

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

P.-L. Hsiung, P. R. Nambiar, and J. G. Fujimoto, “Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography,” J. Biomed. Opt.10(6), 064033 (2005).
[CrossRef] [PubMed]

2004 (3)

M. Wojtkowski, V. Srinivasan, T. Ko, J. Fujimoto, A. Kowalczyk, and J. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

2003 (1)

1984 (1)

R. A. J. Spence, “The venous anatomy of the lower oesophagus in normal subjects and in patients with varices: an image analysis study,” Br. J. Surg.71(10), 739–744 (1984).
[CrossRef] [PubMed]

Amazeen, P.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Armstrong, W. B.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Atif, M.

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

Balalaeva, I.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Baum, B. J.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Betz, C. S.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Beydoun, H.

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Bizheva, K.

Bouma, B. E.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Brenner, M.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

Cable, A.

Chang, C.-C.

Chen, H. M.

Chen, H.-M.

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

Chen, Z.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Chiang, C.-P.

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

M. T. Tsai, H.-C. Lee, C.-K. Lee, C. H. Yu, H. M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008).
[CrossRef] [PubMed]

Chong, C.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

Cirocco, M.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Coleman, C. N.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Conn, B.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Cook, J. A.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Cotrim, A. P.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Crumley, R. L.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Dickinson, M. E.

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

Duker, J.

El Maaytah, M.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Epstein, J.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Feldchtein, F.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Fujimoto, J.

Fujimoto, J. G.

P.-L. Hsiung, P. R. Nambiar, and J. G. Fujimoto, “Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography,” J. Biomed. Opt.10(6), 064033 (2005).
[CrossRef] [PubMed]

Gallant-Behm, C.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Gardiner, G.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Gladkova, N.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Goldenberg, D.

J. J. Sciubba and D. Goldenberg, “Oral complications of radiotherapy,” Lancet Oncol.7(2), 175–183 (2006).
[CrossRef] [PubMed]

Gordon, M.

Gordon, M. L.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Gu, M.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Guo, S.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Haber, G. B.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Häkkinen, L.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Hamdoon, Z.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Hammer-Wilson, M. J.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Hamza, M. Y.

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

Hanna, N. M.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

Hart, D. A.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Hopper, C.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Hsiung, P.-L.

P.-L. Hsiung, P. R. Nambiar, and J. G. Fujimoto, “Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography,” J. Biomed. Opt.10(6), 064033 (2005).
[CrossRef] [PubMed]

Hutchings, N.

Ikram, M.

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

Iksanov, R.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Jackson, R. P.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Jaffer, F. A.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Jarvi, M.

Jay, A.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Jerjes, W.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Jiang, J.

Jin, X.

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

Jung, W. G.

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Jung, W.-G.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Kandel, G.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Karabut, M.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Khurana, M.

Kim, J. W.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Kiseleva, E.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Ko, T.

Kortan, P.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Kowalczyk, A.

Kreuter, K.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Kurabayashi, T.

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

Larin, K. V.

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

Larina, I. V.

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

Larjava, H.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Lee, C.-K.

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

M. T. Tsai, H.-C. Lee, C.-K. Lee, C. H. Yu, H. M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008).
[CrossRef] [PubMed]

Lee, H.-C.

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

M. T. Tsai, H.-C. Lee, C.-K. Lee, C. H. Yu, H. M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008).
[CrossRef] [PubMed]

Lee, K.

Leung, M. K. K.

Lo, S.

Mahmood, U.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Mak, K.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Marcon, N. E.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Mariampillai, A.

Maslennikova, A.

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Matheny, E.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Matheny, E. S.

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

McAuliffe, M.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

McCarthy, J. R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

McKenzie, G.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Messadi, D.

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Mina-Araghi, R.

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

Mitchell, J. B.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Moayed, A. A.

Mok, A.

Moriyama, E. H.

Morse, T.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Muanza, T. M.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Mukai, D.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Munce, N. R.

A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett.33(13), 1530–1532 (2008).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

Namati, E.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Nambiar, P. R.

P.-L. Hsiung, P. R. Nambiar, and J. G. Fujimoto, “Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography,” J. Biomed. Opt.10(6), 064033 (2005).
[CrossRef] [PubMed]

Ntziachristos, V.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Osann, K.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Ozawa, N.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

Pekar, J.

Qi, B.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

V. Yang, M. Gordon, B. Qi, J. Pekar, S. Lo, E. Seng-Yue, A. Mok, B. Wilson, and I. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance,” Opt. Express11(7), 794–809 (2003).
[CrossRef] [PubMed]

Radhi, H.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Ridgway, J. M.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Sandison, A.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Schwartz, J.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Sciubba, J. J.

J. J. Sciubba and D. Goldenberg, “Oral complications of radiotherapy,” Lancet Oncol.7(2), 175–183 (2006).
[CrossRef] [PubMed]

Seng-Yue, E.

Shibuya, T.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Shimozato, K.

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

Shishkov, M.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Shubochkin, R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Simpson, T.

Smolen, J.

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

Sorbara, L.

Sowers, A. L.

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

Spence, R. A. J.

R. A. J. Spence, “The venous anatomy of the lower oesophagus in normal subjects and in patients with varices: an image analysis study,” Br. J. Surg.71(10), 739–744 (1984).
[CrossRef] [PubMed]

Srinivasan, V.

Standish, B. A.

Su, J.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Sudheendran, N.

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

Sumi, Y.

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

Syed, S. H.

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

Tang, S.-j.

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Taylor, K.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Tearney, G. J.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Tsai, M. T.

Tsai, M.-T.

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

Ullah, H.

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

Upile, T.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Vitkin, A.

Vitkin, I.

Vitkin, I. A.

A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett.33(13), 1530–1532 (2008).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Vourvachis, M.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Waite, W.

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Wang, Q.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Wang, Y.-M.

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

M. T. Tsai, H.-C. Lee, C.-K. Lee, C. H. Yu, H. M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008).
[CrossRef] [PubMed]

Wiebe, C.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Wigdor, H.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Wilder-Smith, P.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

Wilson, B.

Wilson, B. C.

A. Mariampillai, M. K. K. Leung, M. Jarvi, B. A. Standish, K. Lee, B. C. Wilson, A. Vitkin, and V. X. D. Yang, “Optimized speckle variance OCT imaging of microvasculature,” Opt. Lett.35(8), 1257–1259 (2010).
[CrossRef] [PubMed]

A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett.33(13), 1530–1532 (2008).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Wojtkowski, M.

Wong, B. J.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Wong, J. W.

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Yang, C. C.

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

M. T. Tsai, H.-C. Lee, C.-K. Lee, C. H. Yu, H. M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008).
[CrossRef] [PubMed]

Yang, C.-C.

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

Yang, V.

Yang, V. X. D.

A. Mariampillai, M. K. K. Leung, M. Jarvi, B. A. Standish, K. Lee, B. C. Wilson, A. Vitkin, and V. X. D. Yang, “Optimized speckle variance OCT imaging of microvasculature,” Opt. Lett.35(8), 1257–1259 (2010).
[CrossRef] [PubMed]

A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett.33(13), 1530–1532 (2008).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

Yoo, H.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Yu, C. H.

Zhang, J.

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Arch. Otolaryngol. Head Neck Surg. (1)

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006).
[CrossRef] [PubMed]

Biomed. Opt. Express (1)

Br. J. Oral Maxillofac. Surg. (2)

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.47(8), 622–626 (2009).
[CrossRef] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg.48(1), 18–25 (2010).
[CrossRef] [PubMed]

Br. J. Surg. (1)

R. A. J. Spence, “The venous anatomy of the lower oesophagus in normal subjects and in patients with varices: an image analysis study,” Br. J. Surg.71(10), 739–744 (1984).
[CrossRef] [PubMed]

Clin. Cancer Res. (2)

T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell, “Evaluation of radiation-induced oral mucositis by optical coherence tomography,” Clin. Cancer Res.11(14), 5121–5127 (2005).
[CrossRef] [PubMed]

P. Wilder-Smith, M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein, “In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography,” Clin. Cancer Res.13(8), 2449–2454 (2007).
[CrossRef] [PubMed]

Gastrointest. Endosc. (1)

V. X. D. Yang, S.-j. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, and N. E. Marcon, “Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience,” Gastrointest. Endosc.61(7), 879–890 (2005).
[CrossRef] [PubMed]

J. Biomed. Opt. (5)

C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009).
[CrossRef] [PubMed]

E. S. Matheny, N. M. Hanna, W. G. Jung, Z. Chen, P. Wilder-Smith, R. Mina-Araghi, and M. Brenner, “Optical coherence tomography of malignancy in hamster cheek pouches,” J. Biomed. Opt.9(5), 978–981 (2004).
[CrossRef] [PubMed]

M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C.-C. Yang, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt.14(4), 044028 (2009).
[CrossRef] [PubMed]

B. A. Standish, X. Jin, J. Smolen, A. Mariampillai, N. R. Munce, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions,” J. Biomed. Opt.12(3), 034022 (2007).
[CrossRef] [PubMed]

P.-L. Hsiung, P. R. Nambiar, and J. G. Fujimoto, “Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography,” J. Biomed. Opt.10(6), 064033 (2005).
[CrossRef] [PubMed]

Lancet Oncol. (1)

J. J. Sciubba and D. Goldenberg, “Oral complications of radiotherapy,” Lancet Oncol.7(2), 175–183 (2006).
[CrossRef] [PubMed]

Laser Phys. Lett. (2)

N. Sudheendran, S. H. Syed, M. E. Dickinson, I. V. Larina, and K. V. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett.8(3), 247–252 (2011).
[CrossRef]

M. Atif, H. Ullah, M. Y. Hamza, and M. Ikram, “Catheters for optical coherence tomography,” Laser Phys. Lett.8, 629–646 (2011).

Lasers Surg. Med. (1)

P. Wilder-Smith, W. G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med.35(4), 269–275 (2004).
[CrossRef] [PubMed]

Med. Laser Appl. (1)

N. Gladkova, A. Maslennikova, I. Balalaeva, F. Feldchtein, E. Kiseleva, M. Karabut, and R. Iksanov, “Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy,” Med. Laser Appl.23(4), 186–195 (2008).
[CrossRef]

Nat. Med. (1)

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. (1)

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009).
[CrossRef] [PubMed]

Photomed. Laser Surg. (1)

N. M. Hanna, W. Waite, K. Taylor, W.-G. Jung, D. Mukai, E. Matheny, K. Kreuter, P. Wilder-Smith, M. Brenner, and Z. Chen, “Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches,” Photomed. Laser Surg.24(3), 402–409 (2006).
[CrossRef] [PubMed]

Wound Repair Regen. (1)

J. W. Wong, C. Gallant-Behm, C. Wiebe, K. Mak, D. A. Hart, H. Larjava, and L. Häkkinen, “Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans,” Wound Repair Regen.17(5), 717–729 (2009).
[CrossRef] [PubMed]

Other (3)

M. Bath-Balogh and M. J. Fehrenbach, Illustrated Dental Embryology, Histology, and Anatomy (Elsevier Saunders, 2011).

J. W. Eveson and C. Scully, Color Atlas of Oral Pathology (Mosby-Wolfe, 1995).

W. Drexler and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer, 2008).

Supplementary Material (1)

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Fig. 1
Fig. 1

(a) Schematic of the SD-OCT system. M: mirror, L: lens, DC: dispersion compensation unit, PC: polarization controllers, DG: diffraction grating, C: circulators (b) Stage for human oral imaging, comprised of the custom-made probe and a head frame. For clarity, the fibers attached to the input (80/20) and output (50/50) couplers are shown in two different colors.

Fig. 2
Fig. 2

(a) Comparison of the light source spectrum at the input to the OCT system (solid line) and at the output of the sample arm (dashed line). The very similar shape and bandwidth signifies that the optics in the OCT system have not caused a spectral distortion (narrowing) and thus a potential reduction of the axial resolution of the system. (b) Decrease in system SNR (proportional to power at the sample arm) as a function of depth, implying a ~13 dB reduction in SNR when going from a depth of ~200 μm to ~1200 μm. The graph is a continuous representation of 22 point measurements.

Fig. 3
Fig. 3

Ex vivo images of pig oral tissue, (a) OCT image and (b) H&E histology of labial tissue; (c) OCT image and (d) H&E histology of buccal tissue; (e) OCT image and (f) H&E histology of dorsal tongue; (g) OCT image and (h) H&E histology of ventral tongue. SL: superficial layer, IL: intermediate layer, BL: basal layer, LP: lamina proria, SM: submucosa, F: fat, M: muscle, BV: blood vessel, *: taste bud. Scale bar = 500 μm.

Fig. 4
Fig. 4

In vivo OCT images of human oral tissue, (a) labial; (b) dorsal surface of the tongue; (c) lateral surface of the tongue; (d) ventral surface of the tongue; (e) buccal; (f) soft palate. SL: superficial layer, IL: intermediate layer, EL: epithelial layer, BL: basal layer, LP: lamina proria, BV: blood vessel, FP: filiform lingual papillae, FoP: foliate lingual papillae, CF: circular furrow, SM: submucosa. Scale bar = 500 μm

Fig. 5
Fig. 5

In vivo OCT images of human labial tissue in (a) absence and (b) presence of ulcer. SL: superficial layer, IL: intermediate layer, BL: basal layer, LP: lamina proria, U: ulcer. Scale bar = 500 μm

Fig. 6
Fig. 6

Consecutive Doppler images and Doppler OCT multimedia of the microvessels in the human labial tissue. The color bar represents the velocity of scatterers in the axial direction. Blue and red hues correspond to two opposite blood flow directions. Microvasculature as small as 16 μm is detectable using the SD-OCT system. Scale bar = 500 μm. Lateral field of view in the multimedia: 1 mm by 1 mm (Media 1)

Fig. 7
Fig. 7

Speckle variance OCT images of the vasculature map in three different regions of the labial tissue of a healthy human volunteer. The images are en face intensity displays formed by projecting three-dimensional tomograms along the depth. The arrows in (a) and (c) show the smallest capillaries detected by the system (~30 μm). Scale bar = 200μm.

Fig. 8
Fig. 8

Speckle variance OCT images in (a) healthy region of the labial tissue, and (b) scar in the labial tissue of the same volunteer. Note the increase in the number of microvasculature in (b); for quantification, see text. Scale bar = 200μm.

Equations (2)

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V z = λ 0 f D 2n
f D = ΔΦ 2πΔt

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