Abstract

Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in the late stages due to the lack of reliable symptoms and efficacious screening techniques. A novel hybrid intraoperative probe has been developed and evaluated for its potential role in detecting and characterizing ovarian tissue. The hybrid intraoperative dual-modality device consists of multiple scintillating fibers and an optical coherence tomography imaging probe for simultaneously mapping the local activities of 18F-FDG uptake and imaging of local morphological changes of the ovary. Ten patients were recruited to the study and a total of 18 normal, abnormal and malignant ovaries were evaluated ex vivo using this device. Positron count rates of 7.5/8.8-fold higher were found between malignant and abnormal/normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for evaluating local regions with high metabolic activities and detecting early malignant changes in the ovary. These initial results have demonstrated that our novel hybrid imager has great potential for ovarian cancer detection and characterization during minimally invasive endoscopic procedures.

© 2011 OSA

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2010

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010).
[CrossRef] [PubMed]

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

R. K. Wang, L. An, P. Francis, and D. J. Wilson, “Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography,” Opt. Lett. 35(9), 1467–1469 (2010).
[CrossRef] [PubMed]

2009

V. J. Srinivasan, Y. Chen, J. S. Duker, and J. G. Fujimoto, “In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT,” Opt. Express 17(5), 3861–3877 (2009).
[CrossRef] [PubMed]

J. Gamelin, Y. Yang, N. Biswal, Y. Chen, S. Yan, X. Zhang, M. Karemeddini, M. Brewer, and Q. Zhu, “A prototype hybrid intraoperative probe for ovarian cancer detection,” Opt. Express 17(9), 7245–7258 (2009).
[CrossRef] [PubMed]

C. L. Evans, I. Rizvi, T. Hasan, and J. F. de Boer, “In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging,” Opt. Express 17(11), 8892–8906 (2009).
[CrossRef] [PubMed]

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

2008

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

P. A. Testoni and B. Mangiavillano, “Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system,” World J. Gastroenterol. 14(42), 6444–6452 (2008).
[CrossRef] [PubMed]

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

2007

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

2006

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

2005

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

N. Pandit-Taskar, “Oncologic imaging in gynecologic malignancies,” J. Nucl. Med. 46(11), 1842–1850 (2005).
[PubMed]

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

2004

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

2003

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

2002

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

2001

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

R. R. Raylman, “Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In,” J. Nucl. Med. 42(2), 352–360 (2001).
[PubMed]

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Ambrosi, G.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

An, L.

Aretz, H. T.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Auricchio, N.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Baehre, M.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Barakat, R. R.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Barlis, P.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Barton, J. K.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Berchuck, A.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Berek, J. S.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Besselsen, D. G.

Biswal, N.

Bogalhas, F.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Bonnema, G. T.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

Borgen, P. I.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Bouma, B. E.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Boyd, J.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Brands, W. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Brewer, M.

J. Gamelin, Y. Yang, N. Biswal, Y. Chen, S. Yan, X. Zhang, M. Karemeddini, M. Brewer, and Q. Zhu, “A prototype hybrid intraoperative probe for ovarian cancer detection,” Opt. Express 17(9), 7245–7258 (2009).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Brewer, M. A.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Buck, A.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Burian, M.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Burke, W. M.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Castiel, M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Chalas, E.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Charon, Y.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Chen, Y.

Chen, Y. C.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Chen, Z.

L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010).
[CrossRef] [PubMed]

Cliby, W. A.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Cobb, M. J.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Daghighian, F.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Daly, M. B.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Davis, J. R.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

de Andrade, M.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

de Boer, J. F.

de Jaegere, P. J.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Domenico, G. D.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Duker, J. S.

Duval, M.-A.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Edelson, M.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Ellis, N. A.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Evans, C. L.

Evans, G.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Fiandrini, E.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fong, Y.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Franc, B. L.

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

Francis, P.

Fujimoto, J. G.

V. J. Srinivasan, Y. Chen, J. S. Duker, and J. G. Fujimoto, “In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT,” Opt. Express 17(5), 3861–3877 (2009).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Gamelin, J.

Garber, J. E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Gerl, J.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Gerner, E. W.

Ghazarossian, V.

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Gmitro, A. F.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Gonzalo, N.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Grossardt, B. R.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

Halpern, E. F.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Hariri, L. P.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

Hasan, T.

Hatch, K. D.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hensley, M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Hoffman, E. J.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Houser, S. L.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Hoyer, P. B.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Hoying, J. B.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hudis, C. A.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Humm, J.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Hunt, K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Hwang, J. H.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Ionica, M.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Isaacs, C.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Iwanczyk, J. S.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Janecek, M.

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Jang, I. K.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Johnson, D.

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

Jungbluth, A.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Kanter, E. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Karemeddini, M.

Kauff, N. D.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Kauffman, C. R.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Kimmey, M. B.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Kirkpatrick, N. D.

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Korde, V.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

Larson, S. M.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Lefebvre, F.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Leong, S. P.

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

Li, X.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lynch, H. T.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

MacDonald, L. R.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Malaguti, R.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Malkasian, G. D.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

Mangiavillano, B.

P. A. Testoni and B. Mangiavillano, “Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system,” World J. Gastroenterol. 14(42), 6444–6452 (2008).
[CrossRef] [PubMed]

Mari, C.

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

Marion, S. L.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Matloff, E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Matsumoto, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

McNally, J. B.

Meisetschläger, G.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Meller, B.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Melton, L. J.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

Ménard, L.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Milano, L.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Minato, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Moore, D. H.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Nafa, K.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Nährig, J.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Narod, S. A.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Neuhausen, S. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Norton, L.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Oelschlager, B. K.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Offit, K.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Old, L.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Olopade, O. I.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Palfi, S.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Pandit-Taskar, N.

N. Pandit-Taskar, “Oncologic imaging in gynecologic malignancies,” J. Nucl. Med. 46(11), 1842–1850 (2005).
[PubMed]

Patt, B. E.

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Piao, D.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

Picchio, M.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Piert, M.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Pinot, L.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Raylman, R. R.

R. R. Raylman, “Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In,” J. Nucl. Med. 42(2), 352–360 (2001).
[PubMed]

Rebbeck, T. R.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Regar, E.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Richter, E.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Rizvi, I.

Robson, M. E.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Rocca, W. A.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

Russo, P.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Sadeghi, M. M.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

Sakamoto, S.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Satagopan, J. M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Scheuer, L.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Schlendorf, K. H.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Schmidt, K.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Schwaiger, M.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Senda, M.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Serruys, P. W.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Shishkov, M.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Siebert, R.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Siewert, J. R.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Sinusas, A. J.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

Sommer, K.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Srinivasan, V. J.

Stein, H. J.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Stevens, S. J.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Strauss, H. W.

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

Strauss, W.

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Strong, V. E.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Surowiec, A.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tarutani, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Tearney, G. J.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Testoni, P. A.

P. A. Testoni and B. Mangiavillano, “Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system,” World J. Gastroenterol. 14(42), 6444–6452 (2008).
[CrossRef] [PubMed]

Tornai, M. P.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

Tsugita, R.

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Tull, C. R.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Tumlinson, A. R.

Upton, M. P.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Utzinger, U.

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

van der Giessen, W. J.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Van’t Veer, L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

von Hof, K.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Walker, R. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Wang, R. K.

Weber, B. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Wilson, D. J.

Winkler, A. M.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

Wollenberg, B.

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Wong, W. D.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Wood, D. E.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Yabushita, H.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Yamaguchi, Y.

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Yamamoto, S.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Yan, S.

Yang, Y.

Yu, L.

L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010).
[CrossRef] [PubMed]

Zavattini, G.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

Zhang, J.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

Zhang, X.

Zhu, Q.

J. Gamelin, Y. Yang, N. Biswal, Y. Chen, S. Yan, X. Zhang, M. Karemeddini, M. Brewer, and Q. Zhu, “A prototype hybrid intraoperative probe for ovarian cancer detection,” Opt. Express 17(9), 7245–7258 (2009).
[CrossRef] [PubMed]

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

Ziegler, S.

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Am. J. Cardiol.

P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008).
[CrossRef] [PubMed]

Ann. Nucl. Med.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, “An intra-operative positron probe with background rejection capability for FDG-guided surgery,” Ann. Nucl. Med. 19(1), 23–28 (2005).
[CrossRef] [PubMed]

Appl. Opt.

Circulation

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003).
[CrossRef] [PubMed]

Clin. Nucl. Med.

B. L. Franc, C. Mari, D. Johnson, and S. P. Leong, “The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanoma,” Clin. Nucl. Med. 30(12), 787–791 (2005).
[CrossRef] [PubMed]

Eur. J. Nucl. Med. Mol. Imaging

M. Piert, M. Burian, G. Meisetschläger, H. J. Stein, S. Ziegler, J. Nährig, M. Picchio, A. Buck, J. R. Siewert, and M. Schwaiger, “Positron detection for the intraoperative localisation of cancer deposits,” Eur. J. Nucl. Med. Mol. Imaging 34(10), 1534–1544 (2007).
[CrossRef] [PubMed]

Gastrointest. Endosc.

M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010).
[CrossRef] [PubMed]

Gynecol. Oncol.

L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009).
[CrossRef] [PubMed]

IEEE Trans. Nucl. Sci.

N. Auricchio, G. D. Domenico, L. Milano, R. Malaguti, G. Ambrosi, M. Ionica, E. Fiandrini, and G. Zavattini, “Characterization of silicon detectors for the SiliPET Project: a small animal PET scanner based on stacks of silicon detectors,” IEEE Trans. Nucl. Sci. 57(5), 2424–2436 (2010).
[CrossRef]

J. Am. Coll. Cardiol.

H. W. Strauss, C. Mari, B. E. Patt, and V. Ghazarossian, “Intravascular radiation detectors for the detection of vulnerable atheroma,” J. Am. Coll. Cardiol. 47(8Suppl), C97–C100 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt.

L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, “Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models,” J. Biomed. Opt. 10(4), 044010 (2005).
[CrossRef] [PubMed]

J. Nucl. Med.

N. Pandit-Taskar, “Oncologic imaging in gynecologic malignancies,” J. Nucl. Med. 46(11), 1842–1850 (2005).
[PubMed]

R. R. Raylman, “Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In,” J. Nucl. Med. 42(2), 352–360 (2001).
[PubMed]

Lancet Oncol.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[CrossRef] [PubMed]

Med. Phys.

M. P. Tornai, B. E. Patt, J. S. Iwanczyk, C. R. Tull, L. R. MacDonald, and E. J. Hoffman, “A novel silicon array designed for intraoperative charged particle imaging,” Med. Phys. 29(11), 2529–2540 (2002).
[CrossRef] [PubMed]

N. Engl. J. Med.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Nucl. Med. (Stuttg.)

B. Meller, K. Sommer, J. Gerl, K. von Hof, A. Surowiec, E. Richter, B. Wollenberg, and M. Baehre, “High energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer,” Nucl. Med. (Stuttg.) 45(4), 153–159 (2006).
[PubMed]

Obstet. Gynecol.

J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

F. Bogalhas, Y. Charon, M.-A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, and L. Ménard, “Development of a positron probe for localization and excision of brain tumours during surgery,” Phys. Med. Biol. 54(14), 4439–4453 (2009).
[CrossRef] [PubMed]

Proc. SPIE

B. E. Patt, J. S. Iwanczyk, L. R. MacDonald, Y. Yamaguchi, C. R. Tull, M. Janecek, E. J. Hoffman, W. Strauss, R. Tsugita, and V. Ghazarossian, “Intravascular probe for detection of vulnerable plaque,” Proc. SPIE 4508, 88–98 (2001).
[CrossRef]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Surg. Endosc.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, and S. M. Larson, “A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes,” Surg. Endosc. 22(2), 386–391 (2008).
[CrossRef] [PubMed]

Technol. Cancer Res. Treat.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004).
[PubMed]

World J. Gastroenterol.

P. A. Testoni and B. Mangiavillano, “Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system,” World J. Gastroenterol. 14(42), 6444–6452 (2008).
[CrossRef] [PubMed]

Other

S. Cherry, J. Sorenson, and M. Phelps, Physics in Nuclear Medicine, 3rd. ed. (Saunders, 2003).

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Figures (7)

Fig. 1
Fig. 1

(a) Schematic of swept-source OCT system. (b) Schematic of positron detection system. (c) Side view of the hybrid probe integrating OCT fiber and nuclear detectors. (d) Tissue surface view of the hybrid probe; (e) Photograph of the hybrid probe. (f) Experimental setup; (g) Co-registration scheme of surface positron distribution map and a sequence of OCT images.

Fig. 2
Fig. 2

One set of images obtained from the left ovary of normal patient #5. (a) Positron distribution map. (b) One representative OCT image obtained from a sequence of co-registered OCT images. (c) Corresponding 40× H&E histology. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2 mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Fig. 3
Fig. 3

One set of images obtained from the right ovary (abnormal) of patient #10. (a) Positron distribution map. (b) One representative OCT image obtained from a sequence of co-registered OCT images. (c) Corresponding 40× H&E histology. Pink arrow, collagen; red oval arrow, congested vessels; yellow diamond arrow, dermoid tumor. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Fig. 4
Fig. 4

One set of images obtained from the left ovary of abnormal patient #9. (a) Positron count rates from different locations of left ovary. (b) Positron distribution map from the location with highest count rate. (c) One representative OCT image obtained from a sequence of co-registered OCT images. (d) Corresponding 40× H&E histology. Red circle, lymphocytes. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Fig. 5
Fig. 5

Two sets of images obtained from the left ovary of patient #7 with malignant ovarian cancers. (a), (b) and (c) are from one side of the left ovary; (d), (e) and (f) are from the other side of the left ovary. (a) and (d): Positron distribution maps. (b) and (e) Representative OCT images obtained from a sequence of co-registered OCT images. (c) and (f) Corresponding 40× H&E histology. Pink arrow, collagen; purple stealth arrow, tumor nodule. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Fig. 6
Fig. 6

One set of images obtained from the right ovary of patient #7 with ovarian cancers. (a) Positron distribution map. (b) One representative OCT image obtained from a sequence of co-registered OCT images. (c) Corresponding 40× H&E histology. Red circle, corpus albicans; purple stealth arrow, tumor. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Fig. 7
Fig. 7

Two sets of images obtained from the right ovary of patient #8 with ovarian cancers. (a), (b) and (c) are from one location; (d), (e) and (f) are from another location. (a) and (d) Positron distribution maps. (b) and (e) Representative OCT images obtained from a sequence of co-registered OCT images. (c) and (f) Corresponding 40× H&E histology. Pink arrow, collagen bundle. The OCT image size is 2 mm (depth) × 5 mm (lateral) (height × width); the histology size is 2mm × 2.6 mm (height × width); the white scale bar is 0.5 mm.

Tables (2)

Tables Icon

Table 1 Patient characteristics and positron measurement (three minutes)

Tables Icon

Table 2 Corresponding histopothology and OCT features of 18 ovaries obtained from 10 patients

Metrics