Abstract

Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.

© 2011 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. Cancer Facts & Figs, 2010 (American Cancer Society, Atlanta, Georgia, 2009). http://www.cancer.org/downloads/STT/Cancer_Facts_and_Figures_2010.pdf .
  2. A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
    [CrossRef] [PubMed]
  3. B. E. Bouma, and G. J. Tearney, eds., Handbook of Optical Coherence Tomography (Marcel Dekker, New York, 2002).
  4. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  5. M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
    [CrossRef] [PubMed]
  6. E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
    [CrossRef] [PubMed]
  7. D. C. Adler, C. Zhou, T. H. Tsai, J. Schmitt, Q. Huang, H. Mashimo, and J. G. Fujimoto, “Three-dimensional endomicroscopy of the human colon using optical coherence tomography,” Opt. Express 17(2), 784–796 (2009).
    [CrossRef] [PubMed]
  8. A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
    [CrossRef] [PubMed]
  9. L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
    [PubMed]
  10. L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
    [CrossRef] [PubMed]
  11. R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
    [PubMed]
  12. A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
    [PubMed]
  13. J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
    [CrossRef] [PubMed]
  14. N. Ramanujam, “Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,” Neoplasia 2(1/2), 89–117 (2000).
    [CrossRef] [PubMed]
  15. A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
    [CrossRef]
  16. R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002).
    [CrossRef] [PubMed]
  17. M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004).
    [PubMed]
  18. S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
    [CrossRef]
  19. E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
    [CrossRef] [PubMed]
  20. L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
    [CrossRef] [PubMed]
  21. Y. Luo, P. J. Gelsinger-Austin, J. M. Watson, G. Barbastathis, J. K. Barton, and R. K. Kostuk, “Laser-induced fluorescence imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system,” Opt. Lett. 33(18), 2098–2100 (2008).
    [CrossRef] [PubMed]
  22. L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
    [CrossRef] [PubMed]
  23. R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
    [CrossRef]
  24. J. K. Barton, A. Tumlinson, and U. Utzinger, “Combined endoscopic optical coherence tomography and laser induced fluorescence,” in Optical Coherence Tomography: Technology and Applications, W. Drexler and J. Fujimoto, eds. (Springer, 2008).
  25. S. Y. Ryu, H. Y. Choi, J. Na, E. S. Choi, and B. H. Lee, “Combined system of optical coherence tomography and fluorescence spectroscopy based on double-cladding fiber,” Opt. Lett. 33(20), 2347–2349 (2008).
    [CrossRef] [PubMed]
  26. J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
    [CrossRef] [PubMed]
  27. A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
    [CrossRef] [PubMed]
  28. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22(18), 1439–1441 (1997).
    [CrossRef] [PubMed]
  29. T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004).
    [CrossRef] [PubMed]
  30. T. J. Pfefer, L. S. Matchette, A. M. Ross, and M. N. Ediger, “Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design,” Opt. Lett. 28(2), 120–122 (2003).
    [CrossRef] [PubMed]
  31. T. J. Pfefer, K. T. Schomacker, M. N. Ediger, and N. S. Nishioka, “Multiple-fiber probe design for fluorescence spectroscopy in tissue,” Appl. Opt. 41(22), 4712–4721 (2002).
    [CrossRef] [PubMed]
  32. R. R. Shannon, “Aberrations,” in The Art and Science of Optical Design (Cambridge University Press, 2006).
  33. J. Sasian, “Optical Design with Mirrors,” presented at Optical Design and Testing Short Course Program, Kyoto, Japan, 15–16 November 1997.
  34. Eksma Optics, “Metallic Coatings,” http://www.eksmaoptics.com/en/p/metallic-coatings-35
  35. E. Hecht, “Propagation of light,” in Optics, 4th ed. (Addison Wesley, 2001).
  36. S. W. Smith, “Special imaging techniques,” in The Scientist and Engineer’s Guide to Digital Signal Processing (California Technical Publishing, 1997), pp. 423–430.
  37. A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
    [CrossRef] [PubMed]

2010

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

2009

2008

2007

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

2006

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

2004

T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004).
[CrossRef] [PubMed]

A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
[CrossRef] [PubMed]

M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004).
[PubMed]

2003

2002

T. J. Pfefer, K. T. Schomacker, M. N. Ediger, and N. S. Nishioka, “Multiple-fiber probe design for fluorescence spectroscopy in tissue,” Appl. Opt. 41(22), 4712–4721 (2002).
[CrossRef] [PubMed]

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002).
[CrossRef] [PubMed]

2001

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

2000

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

N. Ramanujam, “Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,” Neoplasia 2(1/2), 89–117 (2000).
[CrossRef] [PubMed]

1997

1994

A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
[CrossRef]

1991

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

1990

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Adler, D. C.

Akens, M. K.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Alexander, A. L.

A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
[CrossRef]

Baraga, J. J.

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Barbastathis, G.

Barton, J. K.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

Y. Luo, P. J. Gelsinger-Austin, J. M. Watson, G. Barbastathis, J. K. Barton, and R. K. Kostuk, “Laser-induced fluorescence imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system,” Opt. Lett. 33(18), 2098–2100 (2008).
[CrossRef] [PubMed]

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
[CrossRef] [PubMed]

J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22(18), 1439–1441 (1997).
[CrossRef] [PubMed]

Bassett, N.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Besselsen, D. G.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

Brewer, M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Brewer, M. A.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

Chak, A.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chen, D.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Chia, C. T.

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Choi, E. S.

Choi, H. Y.

Cirocco, M.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Connor Davenport, C. M.

A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
[CrossRef]

Das, A.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

Davis, J. R.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

Diong, C. H.

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Douplik, A.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Drexler, W.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Drezek, R.

T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004).
[CrossRef] [PubMed]

Ediger, M. N.

Feld, M. S.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Fengler, J.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Fitzmaurice, M.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fu, S.

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Fujimoto, J. G.

Gaffney, E. J.

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

Gahlen, J.

R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002).
[CrossRef] [PubMed]

Gelikonov, G.

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

Gelikonov, V.

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

Gelikonov, V. M.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Gelsinger-Austin, P. J.

Gerner, E. W.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

Gladkova, N.

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

Gmitro, A. F.

A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
[CrossRef]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hariri, L. P.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
[CrossRef] [PubMed]

Hassan, M.

M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004).
[PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Hoyer, P. B.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Huang, Q.

Ignatenko, N. A.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

Isenberg, G.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

Isenberg, G. A.

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Izatt, J. A.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22(18), 1439–1441 (1997).
[CrossRef] [PubMed]

Kanter, E. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Kirkpatrick, N. D.

Kittrell, C.

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Klaunberg, B. A.

M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004).
[PubMed]

Kobayashi, K.

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Kostuk, R. K.

Kulkarni, M. D.

Kuranov, R. V.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Lee, B. H.

Liebmann, E. R.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lu, E.

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

Lucas, A.

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

Luo, Y.

Marcon, N. E.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Marion, S. L.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Mashimo, H.

Matchette, L. S.

T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004).
[CrossRef] [PubMed]

T. J. Pfefer, L. S. Matchette, A. M. Ross, and M. N. Ediger, “Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design,” Opt. Lett. 28(2), 120–122 (2003).
[CrossRef] [PubMed]

McNally, J.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

McNally, J. B.

Na, J.

Nishioka, N. S.

Petras, R. E.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

Petrova, S. A.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Pfefer, T. J.

Povazay, B.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Prosst, R. L.

R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002).
[CrossRef] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Qiu, Z.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

Radosavljevic, M. J.

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

Ramanujam, N.

N. Ramanujam, “Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,” Neoplasia 2(1/2), 89–117 (2000).
[CrossRef] [PubMed]

Rava, R. P.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Richards-Kortum, R.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

Rollins, A. M.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Ross, A. M.

Ryu, S. Y.

Sapozhnikova, V. V.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Sattmann, H.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Schmitt, J.

Schomacker, K. T.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Seow, C.

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Shakhova, H. M.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Shakhova, N.

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

Sivak, M.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

Sivak, M. V.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tang, C. L.

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Taroni, P.

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

Tsai, T. H.

Tumlinson, A. R.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
[CrossRef] [PubMed]

Ung-Runyawee, R.

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Unterhuber, A.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Utzinger, U.

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004).
[CrossRef] [PubMed]

Wade, N. H.

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

Walker, R. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

Watson, J. M.

Welch, A. J.

Westphal, V.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

Willis, J.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Wilson, B. C.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Wong, R. C.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Yazdanfar, S.

Zagainova, E. V.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Zagaynova, E.

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

Zanati, S.

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Zhou, C.

Appl. Opt.

Can. J. Cardiol.

A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990).
[PubMed]

Cancer Biol. Ther.

L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007).
[CrossRef] [PubMed]

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010).
[CrossRef] [PubMed]

Comp. Med.

L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007).
[PubMed]

M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004).
[PubMed]

Gastrointest. Endosc.

A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001).
[CrossRef] [PubMed]

M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000).
[CrossRef] [PubMed]

Int. J. Colorectal Dis.

R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002).
[CrossRef] [PubMed]

J Biophotonics

E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008).
[CrossRef] [PubMed]

J. Biomed. Opt.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006).
[CrossRef] [PubMed]

Lasers Surg. Med.

J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990).
[CrossRef] [PubMed]

L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006).
[CrossRef] [PubMed]

A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010).
[CrossRef] [PubMed]

Med. Biol. Eng. Comput.

T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004).
[CrossRef] [PubMed]

Neoplasia

N. Ramanujam, “Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,” Neoplasia 2(1/2), 89–117 (2000).
[CrossRef] [PubMed]

Opt. Eng.

A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994).
[CrossRef]

Opt. Express

Opt. Lett.

Photochem. Photobiol.

R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991).
[PubMed]

Proc. SPIE

S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001).
[CrossRef]

Quantum Electron.

R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002).
[CrossRef]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Other

B. E. Bouma, and G. J. Tearney, eds., Handbook of Optical Coherence Tomography (Marcel Dekker, New York, 2002).

Cancer Facts & Figs, 2010 (American Cancer Society, Atlanta, Georgia, 2009). http://www.cancer.org/downloads/STT/Cancer_Facts_and_Figures_2010.pdf .

J. K. Barton, A. Tumlinson, and U. Utzinger, “Combined endoscopic optical coherence tomography and laser induced fluorescence,” in Optical Coherence Tomography: Technology and Applications, W. Drexler and J. Fujimoto, eds. (Springer, 2008).

R. R. Shannon, “Aberrations,” in The Art and Science of Optical Design (Cambridge University Press, 2006).

J. Sasian, “Optical Design with Mirrors,” presented at Optical Design and Testing Short Course Program, Kyoto, Japan, 15–16 November 1997.

Eksma Optics, “Metallic Coatings,” http://www.eksmaoptics.com/en/p/metallic-coatings-35

E. Hecht, “Propagation of light,” in Optics, 4th ed. (Addison Wesley, 2001).

S. W. Smith, “Special imaging techniques,” in The Scientist and Engineer’s Guide to Digital Signal Processing (California Technical Publishing, 1997), pp. 423–430.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1

Block diagram of the dual modality OCT-LIF subsystem, pictured with optional dichroic proximal optics setup (outlined). OCT (1300 nm center wavelength superluminescent diode (SLD)) and LIF (helium:cadmium (He:Cd) with 325 nm excitation wavelength) sources are fiber coupled into focused OCT-LIF endoscope. Neutral density (ND) filters attenuate source power, while spectrometer data is collected by a charge-coupled device (CCD) and electronically transmitted to the central processing unit (CPU).

Fig. 2
Fig. 2

Optical and mechanical design of Focused OCT-LIF Endoscope. Light from fibers secured along inside top surface of endoscope steel tube is focused and reflected downwards onto tissue with novel reflective ball lens design.

Fig. 3
Fig. 3

OCT and LIF excitation spots at window. Spots are only separated by 100 μm circumferentially (x-axis) x 50 μm axially (z-axis).

Fig. 4
Fig. 4

OCT image of 30 mm long mouse colon acquired with new focused OCT-LIF Endoscope.

Fig. 5
Fig. 5

LIF Spectra taken for healthy tissue and adenoma. For adenoma, the emitted fluorescence has a lower intensity and red shifted peak wavelength.

Metrics