Abstract

This feature issue of Biomedical Optics Express presents a cross-section of interesting and emerging work of relevance to optical technologies in low-resource settings. In particular, the technologies described here aim to address challenges to meeting healthcare needs in resource-constrained environments, including in rural and underserved areas. This collection of 18 papers includes papers on both optical system design and image analysis, with applications demonstrated for ex vivo and in vivo use. All together, these works portray the importance of global health research to the scientific community and the role that optics can play in addressing some of the world’s most pressing healthcare challenges.

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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  1. T. Cacace, V. Bianco, B. Mandracchia, V. Pagliarulo, E. Oleandro, M. Paturzo, and P. Ferraro, “Compact off-axis holographic slide microscope: design guidelines,” Biomed. Opt. Express 11(5), 2511 (2020).
    [Crossref]
  2. J. T. Collins, J. Knapper, J. Stirling, J. Mduda, C. Mkindi, V. Mayagaya, G. A. Mwakajinga, P. T. Nyakyi, V. L. Sanga, D. Carbery, L. White, S. Dale, Z. Jieh Lim, J. J. Baumberg, P. Cicuta, S. McDermott, B. Vodenicharski, and R. Bowman, “Robotic microscopy for everyone: the OpenFlexure microscope,” Biomed. Opt. Express 11(5), 2447 (2020).
    [Crossref]
  3. Y. Tang, A. Kortum, S. G. Parra, I. Vohra, A. Milbourne, P. Ramalingam, P. A. Toscano, K. M. Schmeler, and R. R. Richards-Kortum, “In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope,” Biomed. Opt. Express 11(1), 269 (2020).
    [Crossref]
  4. N. A. Szydlowski, H. Jing, M. Alqashmi, and Y. S. Hu, “Cell phone digital microscopy using an oil droplet,” Biomed. Opt. Express 11(5), 2328 (2020).
    [Crossref]
  5. W. Zhu, G. Pirovano, P. K. O’Neal, C. Gong, N. Kulkarni, C. D. Nguyen, C. Brand, T. Reiner, and D. Kang, “Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings,” Biomed. Opt. Express 11(1), 89 (2020).
    [Crossref]
  6. G. N. McKay, N. Mohan, I. Butterworth, A. Bourquard, Á Sánchez-Ferro, C. Castro-González, and N. J. Durr, “Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy,” Biomed. Opt. Express 11(4), 2268 (2020).
    [Crossref]
  7. Q. He and R. Wang, “Hyperspectral imaging enabled by an unmodified smartphone for analyzing skin morphological features and monitoring hemodynamics,” Biomed. Opt. Express 11(2), 895 (2020).
    [Crossref]
  8. I. Nishidate, M. Minakawa, D. McDuff, M. A. Wares, K. Nakano, H. Haneishi, Y. Aizu, and K. Niizeki, “Simple and affordable imaging of multiple physiological parameters with RGB camera-based diffuse reflectance spectroscopy,” Biomed. Opt. Express 11(2), 1073 (2020).
    [Crossref]
  9. D. Wang, X. Yang, X. Liu, J. Jing, and S. Fang, “Detail-preserving pulse wave extraction from facial videos using consumer-level camera,” Biomed. Opt. Express 11(4), 1876 (2020).
    [Crossref]
  10. J.-W. Yu, S.-H. Lim, B. Kim, E. Kim, K. Kim, S. Kyu Park, Y. Seok Byun, J. Sakong, and J.-W. Choi, “Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: a functional near-infrared spectroscopy study,” Biomed. Opt. Express 11(4), 1725 (2020).
    [Crossref]
  11. D. Toslak, F. Chau, M. K. Erol, C. Liu, R. V. P. Chan, T. Son, and X. Yao, “Trans-pars-planar illumination enables a 200° ultra-wide field pediatric fundus camera for easy examination of the retina,” Biomed. Opt. Express 11(1), 68 (2020).
    [Crossref]
  12. T. Rai Dastidar and R. Ethirajan, “Whole slide imaging system using deep learning-based automated focusing,” Biomed. Opt. Express 11(1), 480 (2020).
    [Crossref]
  13. B. D. Haeffele, C. Pick, Z. Lin, E. Mathieu, S. C. Ray, and R. Vidal, “An optical model of whole blood for detecting platelets in lens-free images,” Biomed. Opt. Express 11(4), 1808–1818 (2020).
    [Crossref]
  14. S. Zhu, Z. Huang, and G. Nabi, “Fluorometric optical sensor arrays for the detection of urinary bladder cancer specific volatile organic compounds in the urine of patients with frank hematuria: a prospective case-control study,” Biomed. Opt. Express 11(2), 1175 (2020).
    [Crossref]
  15. M. S. Cano-Velázquez, L. M. López-Marín, and J. Hernández-Cordero, “Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids,” Biomed. Opt. Express 11(3), 1316 (2020).
    [Crossref]
  16. M. Lucidi, M. Marsan, F. Pudda, M. Pirolo, E. Frangipani, P. Visca, and G. Cincotti, “Geometrical-optics approach to measure the optical density of bacterial cultures using a LED-based photometer,” Biomed. Opt. Express 10(11), 5600 (2019).
    [Crossref]
  17. J. Long, H. E. Parker, K. Ehrlich, M. G. Tanner, K. Dhaliwal, and B. Mills, “Frugal filtering optical lenses for point-of-care diagnostics,” Biomed. Opt. Express 11(4), 1864 (2020).
    [Crossref]
  18. A. Goodwin, M. Glancey, T. Ford, L. Scavo, J. Brey, C. Heier, N. J. Durr, and S. Acharya, “Development of a low-cost imaging system for remote mosquito surveillance,” Biomed. Opt. Express 11(5), 2560 (2020).
    [Crossref]

2020 (17)

T. Cacace, V. Bianco, B. Mandracchia, V. Pagliarulo, E. Oleandro, M. Paturzo, and P. Ferraro, “Compact off-axis holographic slide microscope: design guidelines,” Biomed. Opt. Express 11(5), 2511 (2020).
[Crossref]

J. T. Collins, J. Knapper, J. Stirling, J. Mduda, C. Mkindi, V. Mayagaya, G. A. Mwakajinga, P. T. Nyakyi, V. L. Sanga, D. Carbery, L. White, S. Dale, Z. Jieh Lim, J. J. Baumberg, P. Cicuta, S. McDermott, B. Vodenicharski, and R. Bowman, “Robotic microscopy for everyone: the OpenFlexure microscope,” Biomed. Opt. Express 11(5), 2447 (2020).
[Crossref]

Y. Tang, A. Kortum, S. G. Parra, I. Vohra, A. Milbourne, P. Ramalingam, P. A. Toscano, K. M. Schmeler, and R. R. Richards-Kortum, “In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope,” Biomed. Opt. Express 11(1), 269 (2020).
[Crossref]

N. A. Szydlowski, H. Jing, M. Alqashmi, and Y. S. Hu, “Cell phone digital microscopy using an oil droplet,” Biomed. Opt. Express 11(5), 2328 (2020).
[Crossref]

W. Zhu, G. Pirovano, P. K. O’Neal, C. Gong, N. Kulkarni, C. D. Nguyen, C. Brand, T. Reiner, and D. Kang, “Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings,” Biomed. Opt. Express 11(1), 89 (2020).
[Crossref]

G. N. McKay, N. Mohan, I. Butterworth, A. Bourquard, Á Sánchez-Ferro, C. Castro-González, and N. J. Durr, “Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy,” Biomed. Opt. Express 11(4), 2268 (2020).
[Crossref]

Q. He and R. Wang, “Hyperspectral imaging enabled by an unmodified smartphone for analyzing skin morphological features and monitoring hemodynamics,” Biomed. Opt. Express 11(2), 895 (2020).
[Crossref]

I. Nishidate, M. Minakawa, D. McDuff, M. A. Wares, K. Nakano, H. Haneishi, Y. Aizu, and K. Niizeki, “Simple and affordable imaging of multiple physiological parameters with RGB camera-based diffuse reflectance spectroscopy,” Biomed. Opt. Express 11(2), 1073 (2020).
[Crossref]

D. Wang, X. Yang, X. Liu, J. Jing, and S. Fang, “Detail-preserving pulse wave extraction from facial videos using consumer-level camera,” Biomed. Opt. Express 11(4), 1876 (2020).
[Crossref]

J.-W. Yu, S.-H. Lim, B. Kim, E. Kim, K. Kim, S. Kyu Park, Y. Seok Byun, J. Sakong, and J.-W. Choi, “Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: a functional near-infrared spectroscopy study,” Biomed. Opt. Express 11(4), 1725 (2020).
[Crossref]

D. Toslak, F. Chau, M. K. Erol, C. Liu, R. V. P. Chan, T. Son, and X. Yao, “Trans-pars-planar illumination enables a 200° ultra-wide field pediatric fundus camera for easy examination of the retina,” Biomed. Opt. Express 11(1), 68 (2020).
[Crossref]

T. Rai Dastidar and R. Ethirajan, “Whole slide imaging system using deep learning-based automated focusing,” Biomed. Opt. Express 11(1), 480 (2020).
[Crossref]

B. D. Haeffele, C. Pick, Z. Lin, E. Mathieu, S. C. Ray, and R. Vidal, “An optical model of whole blood for detecting platelets in lens-free images,” Biomed. Opt. Express 11(4), 1808–1818 (2020).
[Crossref]

S. Zhu, Z. Huang, and G. Nabi, “Fluorometric optical sensor arrays for the detection of urinary bladder cancer specific volatile organic compounds in the urine of patients with frank hematuria: a prospective case-control study,” Biomed. Opt. Express 11(2), 1175 (2020).
[Crossref]

M. S. Cano-Velázquez, L. M. López-Marín, and J. Hernández-Cordero, “Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids,” Biomed. Opt. Express 11(3), 1316 (2020).
[Crossref]

J. Long, H. E. Parker, K. Ehrlich, M. G. Tanner, K. Dhaliwal, and B. Mills, “Frugal filtering optical lenses for point-of-care diagnostics,” Biomed. Opt. Express 11(4), 1864 (2020).
[Crossref]

A. Goodwin, M. Glancey, T. Ford, L. Scavo, J. Brey, C. Heier, N. J. Durr, and S. Acharya, “Development of a low-cost imaging system for remote mosquito surveillance,” Biomed. Opt. Express 11(5), 2560 (2020).
[Crossref]

2019 (1)

Acharya, S.

Aizu, Y.

Alqashmi, M.

Baumberg, J. J.

Bianco, V.

Bourquard, A.

Bowman, R.

Brand, C.

Brey, J.

Butterworth, I.

Cacace, T.

Cano-Velázquez, M. S.

Carbery, D.

Castro-González, C.

Chan, R. V. P.

Chau, F.

Choi, J.-W.

Cicuta, P.

Cincotti, G.

Collins, J. T.

Dale, S.

Dhaliwal, K.

Durr, N. J.

Ehrlich, K.

Erol, M. K.

Ethirajan, R.

Fang, S.

Ferraro, P.

Ford, T.

Frangipani, E.

Glancey, M.

Gong, C.

Goodwin, A.

Haeffele, B. D.

Haneishi, H.

He, Q.

Heier, C.

Hernández-Cordero, J.

Hu, Y. S.

Huang, Z.

Jieh Lim, Z.

Jing, H.

Jing, J.

Kang, D.

Kim, B.

Kim, E.

Kim, K.

Knapper, J.

Kortum, A.

Kulkarni, N.

Kyu Park, S.

Lim, S.-H.

Lin, Z.

Liu, C.

Liu, X.

Long, J.

López-Marín, L. M.

Lucidi, M.

Mandracchia, B.

Marsan, M.

Mathieu, E.

Mayagaya, V.

McDermott, S.

McDuff, D.

McKay, G. N.

Mduda, J.

Milbourne, A.

Mills, B.

Minakawa, M.

Mkindi, C.

Mohan, N.

Mwakajinga, G. A.

Nabi, G.

Nakano, K.

Nguyen, C. D.

Niizeki, K.

Nishidate, I.

Nyakyi, P. T.

O’Neal, P. K.

Oleandro, E.

Pagliarulo, V.

Parker, H. E.

Parra, S. G.

Paturzo, M.

Pick, C.

Pirolo, M.

Pirovano, G.

Pudda, F.

Rai Dastidar, T.

Ramalingam, P.

Ray, S. C.

Reiner, T.

Richards-Kortum, R. R.

Sakong, J.

Sánchez-Ferro, Á

Sanga, V. L.

Scavo, L.

Schmeler, K. M.

Seok Byun, Y.

Son, T.

Stirling, J.

Szydlowski, N. A.

Tang, Y.

Tanner, M. G.

Toscano, P. A.

Toslak, D.

Vidal, R.

Visca, P.

Vodenicharski, B.

Vohra, I.

Wang, D.

Wang, R.

Wares, M. A.

White, L.

Yang, X.

Yao, X.

Yu, J.-W.

Zhu, S.

Zhu, W.

Biomed. Opt. Express (18)

T. Cacace, V. Bianco, B. Mandracchia, V. Pagliarulo, E. Oleandro, M. Paturzo, and P. Ferraro, “Compact off-axis holographic slide microscope: design guidelines,” Biomed. Opt. Express 11(5), 2511 (2020).
[Crossref]

J. T. Collins, J. Knapper, J. Stirling, J. Mduda, C. Mkindi, V. Mayagaya, G. A. Mwakajinga, P. T. Nyakyi, V. L. Sanga, D. Carbery, L. White, S. Dale, Z. Jieh Lim, J. J. Baumberg, P. Cicuta, S. McDermott, B. Vodenicharski, and R. Bowman, “Robotic microscopy for everyone: the OpenFlexure microscope,” Biomed. Opt. Express 11(5), 2447 (2020).
[Crossref]

Y. Tang, A. Kortum, S. G. Parra, I. Vohra, A. Milbourne, P. Ramalingam, P. A. Toscano, K. M. Schmeler, and R. R. Richards-Kortum, “In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope,” Biomed. Opt. Express 11(1), 269 (2020).
[Crossref]

N. A. Szydlowski, H. Jing, M. Alqashmi, and Y. S. Hu, “Cell phone digital microscopy using an oil droplet,” Biomed. Opt. Express 11(5), 2328 (2020).
[Crossref]

W. Zhu, G. Pirovano, P. K. O’Neal, C. Gong, N. Kulkarni, C. D. Nguyen, C. Brand, T. Reiner, and D. Kang, “Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings,” Biomed. Opt. Express 11(1), 89 (2020).
[Crossref]

G. N. McKay, N. Mohan, I. Butterworth, A. Bourquard, Á Sánchez-Ferro, C. Castro-González, and N. J. Durr, “Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy,” Biomed. Opt. Express 11(4), 2268 (2020).
[Crossref]

Q. He and R. Wang, “Hyperspectral imaging enabled by an unmodified smartphone for analyzing skin morphological features and monitoring hemodynamics,” Biomed. Opt. Express 11(2), 895 (2020).
[Crossref]

I. Nishidate, M. Minakawa, D. McDuff, M. A. Wares, K. Nakano, H. Haneishi, Y. Aizu, and K. Niizeki, “Simple and affordable imaging of multiple physiological parameters with RGB camera-based diffuse reflectance spectroscopy,” Biomed. Opt. Express 11(2), 1073 (2020).
[Crossref]

D. Wang, X. Yang, X. Liu, J. Jing, and S. Fang, “Detail-preserving pulse wave extraction from facial videos using consumer-level camera,” Biomed. Opt. Express 11(4), 1876 (2020).
[Crossref]

J.-W. Yu, S.-H. Lim, B. Kim, E. Kim, K. Kim, S. Kyu Park, Y. Seok Byun, J. Sakong, and J.-W. Choi, “Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: a functional near-infrared spectroscopy study,” Biomed. Opt. Express 11(4), 1725 (2020).
[Crossref]

D. Toslak, F. Chau, M. K. Erol, C. Liu, R. V. P. Chan, T. Son, and X. Yao, “Trans-pars-planar illumination enables a 200° ultra-wide field pediatric fundus camera for easy examination of the retina,” Biomed. Opt. Express 11(1), 68 (2020).
[Crossref]

T. Rai Dastidar and R. Ethirajan, “Whole slide imaging system using deep learning-based automated focusing,” Biomed. Opt. Express 11(1), 480 (2020).
[Crossref]

B. D. Haeffele, C. Pick, Z. Lin, E. Mathieu, S. C. Ray, and R. Vidal, “An optical model of whole blood for detecting platelets in lens-free images,” Biomed. Opt. Express 11(4), 1808–1818 (2020).
[Crossref]

S. Zhu, Z. Huang, and G. Nabi, “Fluorometric optical sensor arrays for the detection of urinary bladder cancer specific volatile organic compounds in the urine of patients with frank hematuria: a prospective case-control study,” Biomed. Opt. Express 11(2), 1175 (2020).
[Crossref]

M. S. Cano-Velázquez, L. M. López-Marín, and J. Hernández-Cordero, “Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids,” Biomed. Opt. Express 11(3), 1316 (2020).
[Crossref]

M. Lucidi, M. Marsan, F. Pudda, M. Pirolo, E. Frangipani, P. Visca, and G. Cincotti, “Geometrical-optics approach to measure the optical density of bacterial cultures using a LED-based photometer,” Biomed. Opt. Express 10(11), 5600 (2019).
[Crossref]

J. Long, H. E. Parker, K. Ehrlich, M. G. Tanner, K. Dhaliwal, and B. Mills, “Frugal filtering optical lenses for point-of-care diagnostics,” Biomed. Opt. Express 11(4), 1864 (2020).
[Crossref]

A. Goodwin, M. Glancey, T. Ford, L. Scavo, J. Brey, C. Heier, N. J. Durr, and S. Acharya, “Development of a low-cost imaging system for remote mosquito surveillance,” Biomed. Opt. Express 11(5), 2560 (2020).
[Crossref]

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