Abstract

Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Characterization of the formed debris on the optical fibers after electrosurgery revealed that the contamination is mostly burned tissue. Even with contaminated optical fibers, both tissues could still be discriminated with DRS based on fat/water ratio. Therefore, an electrosurgical knife integrated with DRS may be a promising technology to provide the surgeon with real-time guidance during BCS.

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (5)

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
[Crossref]

E. R. Sauter, “Breast cancer prevention: Current approaches and future directions,” Eur J Breast Health 14(2), 64 (2018).

C. Reyna and S. M. DeSnyder, “Intraoperative margin assessment in breast cancer management,” Surg Oncol Clin N Am 27(1), 155–165 (2018).
[Crossref]

A. Keller, P. Bialecki, T. J. Wilhelm, and M. K. Vetter, “Diffuse reflectance spectroscopy of human liver tumor specimens-towards a tissue differentiating optical biopsy needle using light emitting diodes,” Biomed. Opt. Express 9(3), 1069–1081 (2018).
[Crossref]

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

2017 (3)

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
[Crossref]

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

2016 (3)

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

L. L. de Boer, B. H. Hendriks, F. Van Duijnhoven, M.-J. T. V. Peeters-Baas, K. Van de Vijver, C. E. Loo, K. Jóźwiak, H. J. Sterenborg, and T. J. Ruers, “Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation,” Biomed. Opt. Express 7(12), 5188–5200 (2016).
[Crossref]

C. M. O’Kelly Priddy, V. A. Forte, and J. E. Lang, “The importance of surgical margins in breast cancer,” J. Surg. Oncol. 113(3), 256–263 (2016).
[Crossref]

2015 (5)

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
[Crossref]

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref]

2014 (3)

J. W. Spliethoff, E. Tanis, D. J. Evers, B. H. Hendriks, W. Prevoo, and T. J. Ruers, “Monitoring of tumor radio frequency ablation using derivative spectroscopy,” J. Biomed. Opt. 19(9), 097004 (2014).
[Crossref]

A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
[Crossref]

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

2013 (4)

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
[Crossref]

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

G. A. Vilos and C. Rajakumar, “Electrosurgical generators and monopolar and bipolar electrosurgery,” J Minim Invasive Gynecol 20(3), 279–287 (2013).
[Crossref]

M. Annals of surgeryRedígolo, R. Aguiar, C. Zamboni, and I. Sato, “Determination of reference interval values for inorganic elements in whole blood samples of humans and laboratory animals by X-ray fluorescence spectrometry,” J. Radioanal. Nucl. Chem. 297(3), 463–467 (2013).
[Crossref]

2012 (2)

C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, “NIH Image to ImageJ: 25 years of image analysis,” Nat. Methods 9(7), 671–675 (2012).
[Crossref]

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

2011 (1)

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

2010 (3)

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

R. Nachabé, B. H. Hendriks, M. van der Voort, A. E. Desjardins, and H. J. Sterenborg, “Estimation of biological chromophores using diffuse optical spectroscopy: benefit of extending the UV-VIS wavelength range to include 1000 to 1600 nm,” Biomed. Opt. Express 1(5), 1432–1442 (2010).
[Crossref]

R. Nachabe, B. H. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. J. J. o. b. o. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[Crossref]

2009 (1)

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
[Crossref]

2008 (1)

L. Jacobs, “Positive margins: the challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref]

2002 (1)

A. Yaroslavsky, P. Schulze, I. Yaroslavsky, R. Schober, F. Ulrich, and H. Schwarzmaier, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys. Med. Biol. 47(12), 3052059–2073 (2002).
[Crossref]

2001 (1)

J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
[Crossref]

1990 (1)

G. J. Derbyshire, D. K. Bogen, and M. Unger, “Thermally induced optical property changes in myocardium at 1.06 μm,” Lasers Surg. Med. 10(1), 28–34 (1990).
[Crossref]

Aalbers, A. G.

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

Adank, M. W.

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
[Crossref]

Aguiar, R.

M. Annals of surgeryRedígolo, R. Aguiar, C. Zamboni, and I. Sato, “Determination of reference interval values for inorganic elements in whole blood samples of humans and laboratory animals by X-ray fluorescence spectrometry,” J. Radioanal. Nucl. Chem. 297(3), 463–467 (2013).
[Crossref]

Al-Khudairi, R.

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
[Crossref]

Allen, P. J.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Amen, M.

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Andrews, V.

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Ashrafian, H.

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
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E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
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M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
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E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
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Bart, J.

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
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E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
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Bialecki, P.

Blumgart, L. H.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
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G. J. Derbyshire, D. K. Bogen, and M. Unger, “Thermally induced optical property changes in myocardium at 1.06 μm,” Lasers Surg. Med. 10(1), 28–34 (1990).
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C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
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J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
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Bydlon, T.

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
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L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
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T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
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S. C. Feng, F. Zeng, and B. Chance, “Monte Carlo simulations of photon migration path distributions in multiple scattering media,” in Photon Migration and Imaging in Random Media and Tissues, (International Society for Optics and Photonics, 1993), 78–89.

Chavez-MacGregor, M.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
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C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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Dankelman, J.

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
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Darzi, A.

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
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C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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De Boer, L.

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
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De Boer, L. L.

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
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L. L. de Boer, B. H. Hendriks, F. Van Duijnhoven, M.-J. T. V. Peeters-Baas, K. Van de Vijver, C. E. Loo, K. Jóźwiak, H. J. Sterenborg, and T. J. Ruers, “Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation,” Biomed. Opt. Express 7(12), 5188–5200 (2016).
[Crossref]

L. L. de Boer, E. Kho, F. van Duijnhoven, M.-J. T. V. Peeters, K. K. Van de Vijver, B. H. Hendriks, H. J. Sterenborg, and T. J. Ruers, “Towards detection of positive resection margins with diffuse reflectance spectroscopy during breast conserving surgery (Conference Presentation),” in Diseases in the Breast and Reproductive System V, (International Society for Optics and Photonics, 2019), 108560H.

de Jong, J.

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

de Jong, J. S.

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
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E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

de Vries, J.

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
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E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Derbyshire, G. J.

G. J. Derbyshire, D. K. Bogen, and M. Unger, “Thermally induced optical property changes in myocardium at 1.06 μm,” Lasers Surg. Med. 10(1), 28–34 (1990).
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R. Nachabé, B. H. Hendriks, M. van der Voort, A. E. Desjardins, and H. J. Sterenborg, “Estimation of biological chromophores using diffuse optical spectroscopy: benefit of extending the UV-VIS wavelength range to include 1000 to 1600 nm,” Biomed. Opt. Express 1(5), 1432–1442 (2010).
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R. Nachabe, B. H. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. J. J. o. b. o. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
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M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
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Dionigi, G.

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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Dionigi, R.

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
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R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
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R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
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J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

J. W. Spliethoff, E. Tanis, D. J. Evers, B. H. Hendriks, W. Prevoo, and T. J. Ruers, “Monitoring of tumor radio frequency ablation using derivative spectroscopy,” J. Biomed. Opt. 19(9), 097004 (2014).
[Crossref]

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

Fachinetti, A.

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
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A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
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S. C. Feng, F. Zeng, and B. Chance, “Monte Carlo simulations of photon migration path distributions in multiple scattering media,” in Photon Migration and Imaging in Random Media and Tissues, (International Society for Optics and Photonics, 1993), 78–89.

Fleischer, J. C.

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
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C. M. O’Kelly Priddy, V. A. Forte, and J. E. Lang, “The importance of surgical margins in breast cancer,” J. Surg. Oncol. 113(3), 256–263 (2016).
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M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
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B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
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Geradts, J.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Germer, C. T.

J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
[Crossref]

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M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
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E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Graafland, M.

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
[Crossref]

Greenup, R. A.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Guiot, M.-C.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Hadjiminas, D. J.

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
[Crossref]

Harris, J. R.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Hendriks, B.

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
[Crossref]

Hendriks, B. H.

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
[Crossref]

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

L. L. de Boer, B. H. Hendriks, F. Van Duijnhoven, M.-J. T. V. Peeters-Baas, K. Van de Vijver, C. E. Loo, K. Jóźwiak, H. J. Sterenborg, and T. J. Ruers, “Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation,” Biomed. Opt. Express 7(12), 5188–5200 (2016).
[Crossref]

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref]

J. W. Spliethoff, E. Tanis, D. J. Evers, B. H. Hendriks, W. Prevoo, and T. J. Ruers, “Monitoring of tumor radio frequency ablation using derivative spectroscopy,” J. Biomed. Opt. 19(9), 097004 (2014).
[Crossref]

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

R. Nachabe, B. H. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. J. J. o. b. o. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[Crossref]

R. Nachabé, B. H. Hendriks, M. van der Voort, A. E. Desjardins, and H. J. Sterenborg, “Estimation of biological chromophores using diffuse optical spectroscopy: benefit of extending the UV-VIS wavelength range to include 1000 to 1600 nm,” Biomed. Opt. Express 1(5), 1432–1442 (2010).
[Crossref]

L. L. de Boer, E. Kho, F. van Duijnhoven, M.-J. T. V. Peeters, K. K. Van de Vijver, B. H. Hendriks, H. J. Sterenborg, and T. J. Ruers, “Towards detection of positive resection margins with diffuse reflectance spectroscopy during breast conserving surgery (Conference Presentation),” in Diseases in the Breast and Reproductive System V, (International Society for Optics and Photonics, 2019), 108560H.

Hompes, D.

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

Horton, J.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Houssami, N.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Isbert, C.

J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
[Crossref]

Jacobs, L.

L. Jacobs, “Positive margins: the challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref]

Jermyn, M.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Josse, G.

A. Koenig, B. Roig, J. Le Digabel, G. Josse, and J.-M. Dinten, “Accessing deep optical properties of skin using diffuse reflectance spectroscopy,” in European Conference on Biomedical Optics, (Optical Society of America, 2015), 95370E.

Joy, D. C.

J. I. Goldstein, D. E. Newbury, J. R. Michael, N. W. Ritchie, J. H. J. Scott, and D. C. Joy, Scanning Electron Microscopy and X-ray Microanalysis (Springer, 2017).

Józwiak, K.

Karamchandiani, J.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Keller, A.

Kemeny, N.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Khan, S. A.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Kho, E.

L. L. de Boer, E. Kho, F. van Duijnhoven, M.-J. T. V. Peeters, K. K. Van de Vijver, B. H. Hendriks, H. J. Sterenborg, and T. J. Ruers, “Towards detection of positive resection margins with diffuse reflectance spectroscopy during breast conserving surgery (Conference Presentation),” in Diseases in the Breast and Reproductive System V, (International Society for Optics and Photonics, 2019), 108560H.

Kingham, T. P.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Klein, R. L.

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

Klimberg, S.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Klomp, H. M.

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

Koenig, A.

A. Koenig, B. Roig, J. Le Digabel, G. Josse, and J.-M. Dinten, “Accessing deep optical properties of skin using diffuse reflectance spectroscopy,” in European Conference on Biomedical Optics, (Optical Society of America, 2015), 95370E.

Koerkamp, B. G.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Kok, N.

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

Krieger, M. S.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Kuhlmann, K. F.

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

Lang, J. E.

C. M. O’Kelly Priddy, V. A. Forte, and J. E. Lang, “The importance of surgical margins in breast cancer,” J. Surg. Oncol. 113(3), 256–263 (2016).
[Crossref]

Le Digabel, J.

A. Koenig, B. Roig, J. Le Digabel, G. Josse, and J.-M. Dinten, “Accessing deep optical properties of skin using diffuse reflectance spectroscopy,” in European Conference on Biomedical Optics, (Optical Society of America, 2015), 95370E.

Leal, J. N.

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Leblond, F.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Leff, D. R.

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
[Crossref]

Leitch, A. M.

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

Loo, C. E.

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

L. L. de Boer, B. H. Hendriks, F. Van Duijnhoven, M.-J. T. V. Peeters-Baas, K. Van de Vijver, C. E. Loo, K. Jóźwiak, H. J. Sterenborg, and T. J. Ruers, “Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation,” Biomed. Opt. Express 7(12), 5188–5200 (2016).
[Crossref]

Lucassen, G. W.

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

Mansoori, P.

A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
[Crossref]

Marchionini, V.

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
[Crossref]

Marple, E.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Meier, M. A.

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

Mercier, J.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Michael, J. R.

J. I. Goldstein, D. E. Newbury, J. R. Michael, N. W. Ritchie, J. H. J. Scott, and D. C. Joy, Scanning Electron Microscopy and X-ray Microanalysis (Springer, 2017).

Moldrem, A.

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Molenkamp, B.

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
[Crossref]

Mook, J. A.

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

Moran, M. S.

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

Morrow, M.

M. Pilewskie and M. Morrow, “Extent and role of margin control for DCIS managed by breast-conserving surgery,” in Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer (Springer, 2015), pp. 67–83.

Müller, G.

J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
[Crossref]

Mulvey, C. S.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Munro, M. G.

M. G. Munro, “Fundamentals of electrosurgery part I: principles of radiofrequency energy for surgery,” in The SAGES Manual on the Fundamental Use of Surgical Energy (FUSE) (Springer, 2012), pp. 15–59.
[Crossref]

Nachabe, R.

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabe, B. H. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. J. J. o. b. o. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[Crossref]

Nachabé, R.

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

R. Nachabé, B. H. Hendriks, M. van der Voort, A. E. Desjardins, and H. J. Sterenborg, “Estimation of biological chromophores using diffuse optical spectroscopy: benefit of extending the UV-VIS wavelength range to include 1000 to 1600 nm,” Biomed. Opt. Express 1(5), 1432–1442 (2010).
[Crossref]

Newbury, D. E.

J. I. Goldstein, D. E. Newbury, J. R. Michael, N. W. Ritchie, J. H. J. Scott, and D. C. Joy, Scanning Electron Microscopy and X-ray Microanalysis (Springer, 2017).

Nichols, B. S.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

O’Kelly Priddy, C. M.

C. M. O’Kelly Priddy, V. A. Forte, and J. E. Lang, “The importance of surgical margins in breast cancer,” J. Surg. Oncol. 113(3), 256–263 (2016).
[Crossref]

Oldenburg, H. S.

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

Pearce, D.

A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
[Crossref]

Peeters, M.-J. T. V.

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

L. L. de Boer, E. Kho, F. van Duijnhoven, M.-J. T. V. Peeters, K. K. Van de Vijver, B. H. Hendriks, H. J. Sterenborg, and T. J. Ruers, “Towards detection of positive resection margins with diffuse reflectance spectroscopy during breast conserving surgery (Conference Presentation),” in Diseases in the Breast and Reproductive System V, (International Society for Optics and Photonics, 2019), 108560H.

Peeters, M.-J. V.

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

Peeters-Baas, M.-J. T. V.

Petrecca, K.

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Pilewskie, M.

M. Pilewskie and M. Morrow, “Extent and role of margin control for DCIS managed by breast-conserving surgery,” in Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer (Springer, 2015), pp. 67–83.

Pleijhuis, R. G.

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
[Crossref]

Porte, R. J.

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

Prevoo, W.

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

J. W. Spliethoff, E. Tanis, D. J. Evers, B. H. Hendriks, W. Prevoo, and T. J. Ruers, “Monitoring of tumor radio frequency ablation using derivative spectroscopy,” J. Biomed. Opt. 19(9), 097004 (2014).
[Crossref]

Pully, V. V.

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

Radford, L.

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Rajakumar, C.

G. A. Vilos and C. Rajakumar, “Electrosurgical generators and monopolar and bipolar electrosurgery,” J Minim Invasive Gynecol 20(3), 279–287 (2013).
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L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
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White, J.

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Wilhelm, T. J.

Wilke, L. G.

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Williford, P. M.

A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
[Crossref]

Winter-Warnars, G. A.

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

Wynn, R. T.

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

Yaroslavsky, A.

A. Yaroslavsky, P. Schulze, I. Yaroslavsky, R. Schober, F. Ulrich, and H. Schwarzmaier, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys. Med. Biol. 47(12), 3052059–2073 (2002).
[Crossref]

Yaroslavsky, I.

A. Yaroslavsky, P. Schulze, I. Yaroslavsky, R. Schober, F. Ulrich, and H. Schwarzmaier, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys. Med. Biol. 47(12), 3052059–2073 (2002).
[Crossref]

Zamboni, C.

M. Annals of surgeryRedígolo, R. Aguiar, C. Zamboni, and I. Sato, “Determination of reference interval values for inorganic elements in whole blood samples of humans and laboratory animals by X-ray fluorescence spectrometry,” J. Radioanal. Nucl. Chem. 297(3), 463–467 (2013).
[Crossref]

Zeng, F.

S. C. Feng, F. Zeng, and B. Chance, “Monte Carlo simulations of photon migration path distributions in multiple scattering media,” in Photon Migration and Imaging in Random Media and Tissues, (International Society for Optics and Photonics, 1993), 78–89.

Ann Surg Oncol (1)

R. Rao, A. Moldrem, V. Sarode, J. White, M. Amen, M. Rao, V. Andrews, D. Euhus, L. Radford, and M. Ulissey, “Experience with seed localization for nonpalpable breast lesions in a public health care system,” Ann Surg Oncol 17(12), 3241–3246 (2010).
[Crossref]

Ann. Surg. (2)

E. R. St John, R. Al-Khudairi, H. Ashrafian, T. Athanasiou, Z. Takats, D. J. Hadjiminas, A. Darzi, and D. R. Leff, “Diagnostic accuracy of intraoperative techniques for margin assessment in breast cancer surgery,” Ann. Surg. 265(2), 300–310 (2017).
[Crossref]

E. Sadot, B. G. Koerkamp, J. N. Leal, J. Shia, M. Gonen, P. J. Allen, R. P. DeMatteo, T. P. Kingham, N. Kemeny, and L. H. Blumgart, “Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?” Ann. Surg. 262(3), 476–485 (2015).
[Crossref]

Ann. Surg. Oncol. (3)

M. S. Moran, S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, M. Chavez-MacGregor, G. Freedman, and N. Houssami, “Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer,” Ann. Surg. Oncol. 21(3), 704–716 (2014).
[Crossref]

R. G. Pleijhuis, M. Graafland, J. de Vries, J. Bart, J. S. de Jong, and G. M. van Dam, “Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions,” Ann. Surg. Oncol. 16(10), 2717–2730 (2009).
[Crossref]

L. Jacobs, “Positive margins: the challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref]

Biomed. Opt. Express (3)

Breast Cancer Res. Treat. (2)

L. De Boer, B. Molenkamp, T. Bydlon, B. Hendriks, J. Wesseling, H. Sterenborg, and T. J. Ruers, “Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries,” Breast Cancer Res. Treat. 152(3), 509–518 (2015).
[Crossref]

D. J. Evers, R. Nachabe, M.-J. V. Peeters, J. A. van der Hage, H. S. Oldenburg, E. J. Rutgers, G. W. Lucassen, B. H. Hendriks, J. Wesseling, and T. J. Ruers, “Diffuse reflectance spectroscopy: towards clinical application in breast cancer,” Breast Cancer Res. Treat. 137(1), 155–165 (2013).
[Crossref]

Cancer Res. (1)

M. Jermyn, J. Mercier, K. Aubertin, J. Desroches, K. Urmey, J. Karamchandiani, E. Marple, M.-C. Guiot, F. Leblond, and K. Petrecca, “Highly accurate detection of cancer in situ with intraoperative, label-free, multimodal optical spectroscopy,” Cancer Res. 77(14), 3942–3950 (2017).
[Crossref]

Clin. Cancer Res. (1)

J. W. Spliethoff, W. Prevoo, M. A. Meier, J. de Jong, H. M. Klomp, D. J. Evers, H. J. Sterenborg, G. W. Lucassen, B. H. Hendriks, and T. J. Ruers, “Real-time in vivo tissue characterization with diffuse reflectance spectroscopy during transthoracic lung biopsy: a clinical feasibility study,” Clin. Cancer Res. 22(2), 357–365 (2016).
[Crossref]

Eur J Breast Health (1)

E. R. Sauter, “Breast cancer prevention: Current approaches and future directions,” Eur J Breast Health 14(2), 64 (2018).

Int. J. Surg. (1)

C. Chiappa, F. Rovera, A. D. Corben, A. Fachinetti, V. De Berardinis, V. Marchionini, S. Rausei, L. Boni, G. Dionigi, and R. Dionigi, “Surgical margins in breast conservation,” Int. J. Surg. 11, S69–S72 (2013).
[Crossref]

J Minim Invasive Gynecol (1)

G. A. Vilos and C. Rajakumar, “Electrosurgical generators and monopolar and bipolar electrosurgery,” J Minim Invasive Gynecol 20(3), 279–287 (2013).
[Crossref]

J. Am. Acad. Dermatol. (1)

A. Taheri, P. Mansoori, L. F. Sandoval, S. R. Feldman, D. Pearce, and P. M. Williford, “Electrosurgery: part II. Technology, applications, and safety of electrosurgical devices,” J. Am. Acad. Dermatol. 70(4), 607.e1–607.e12 (2014).
[Crossref]

J. Biomed. Opt. (5)

R. Nachabé, B. H. Hendriks, G. W. Lucassen, M. van der Voort, D. J. Evers, E. J. Rutgers, M.-J. V. Peeters, J. A. Van der Hage, H. S. Oldenburg, and T. J. Ruers, “Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods,” J. Biomed. Opt. 16(8), 087010 (2011).
[Crossref]

R. Nachabe, B. H. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. J. J. o. b. o. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[Crossref]

E. J. Baltussen, P. Snæbjörnsson, S. G. B. De Koning, H. J. Sterenborg, A. G. Aalbers, N. Kok, G. L. Beets, B. H. Hendriks, K. F. Kuhlmann, and T. J. Ruers, “Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery,” J. Biomed. Opt. 22(10), 1 (2017).
[Crossref]

M. W. Adank, J. C. Fleischer, J. Dankelman, and B. H. Hendriks, “Real-time oncological guidance using diffuse reflectance spectroscopy in electrosurgery: the effect of coagulation on tissue discrimination,” J. Biomed. Opt. 23(11), 1 (2018).
[Crossref]

J. W. Spliethoff, E. Tanis, D. J. Evers, B. H. Hendriks, W. Prevoo, and T. J. Ruers, “Monitoring of tumor radio frequency ablation using derivative spectroscopy,” J. Biomed. Opt. 19(9), 097004 (2014).
[Crossref]

J. Biophotonics (1)

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref]

J. Radioanal. Nucl. Chem. (1)

M. Annals of surgeryRedígolo, R. Aguiar, C. Zamboni, and I. Sato, “Determination of reference interval values for inorganic elements in whole blood samples of humans and laboratory animals by X-ray fluorescence spectrometry,” J. Radioanal. Nucl. Chem. 297(3), 463–467 (2013).
[Crossref]

J. Surg. Oncol. (2)

C. M. O’Kelly Priddy, V. A. Forte, and J. E. Lang, “The importance of surgical margins in breast cancer,” J. Surg. Oncol. 113(3), 256–263 (2016).
[Crossref]

R. L. Klein, J. A. Mook, D. M. Euhus, R. Rao, R. T. Wynn, A. B. Eastman, and A. M. Leitch, “Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions,” J. Surg. Oncol. 105(6), 591–594 (2012).
[Crossref]

J. Transl. Med. (1)

L. L. De Boer, T. M. Bydlon, F. Van Duijnhoven, M.-J. T. V. Peeters, C. E. Loo, G. A. Winter-Warnars, J. Sanders, H. J. Sterenborg, B. H. Hendriks, and T. J. Ruers, “Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery,” J. Transl. Med. 16(1), 367 (2018).
[Crossref]

Lasers Surg. Med. (2)

G. J. Derbyshire, D. K. Bogen, and M. Unger, “Thermally induced optical property changes in myocardium at 1.06 μm,” Lasers Surg. Med. 10(1), 28–34 (1990).
[Crossref]

J. P. Ritz, A. Roggan, C. Isbert, G. Müller, H. J. Buhr, and C. T. Germer, “Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm,” Lasers Surg. Med. 29(3), 205–212 (2001).
[Crossref]

Nat. Methods (1)

C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, “NIH Image to ImageJ: 25 years of image analysis,” Nat. Methods 9(7), 671–675 (2012).
[Crossref]

Phys. Med. Biol. (1)

A. Yaroslavsky, P. Schulze, I. Yaroslavsky, R. Schober, F. Ulrich, and H. Schwarzmaier, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys. Med. Biol. 47(12), 3052059–2073 (2002).
[Crossref]

PLoS One (1)

B. S. Nichols, C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. A. Greenup, and J. A. Von Windheim, “A quantitative diffuse reflectance imaging (QDRI) system for comprehensive surveillance of the morphological landscape in breast tumor margins,” PLoS One 10, e0127525 (2015).
[Crossref]

Surg Oncol Clin N Am (1)

C. Reyna and S. M. DeSnyder, “Intraoperative margin assessment in breast cancer management,” Surg Oncol Clin N Am 27(1), 155–165 (2018).
[Crossref]

Transplant Int. (1)

D. J. Evers, A. C. Westerkamp, J. W. Spliethoff, V. V. Pully, D. Hompes, B. H. Hendriks, W. Prevoo, M. L. F. van Velthuysen, R. J. Porte, and T. J. Ruers, “Diffuse reflectance spectroscopy: toward real-time quantification of steatosis in liver,” Transplant Int. 28(4), 465–474 (2015).
[Crossref]

Other (6)

J. I. Goldstein, D. E. Newbury, J. R. Michael, N. W. Ritchie, J. H. J. Scott, and D. C. Joy, Scanning Electron Microscopy and X-ray Microanalysis (Springer, 2017).

M. G. Munro, “Fundamentals of electrosurgery part I: principles of radiofrequency energy for surgery,” in The SAGES Manual on the Fundamental Use of Surgical Energy (FUSE) (Springer, 2012), pp. 15–59.
[Crossref]

S. C. Feng, F. Zeng, and B. Chance, “Monte Carlo simulations of photon migration path distributions in multiple scattering media,” in Photon Migration and Imaging in Random Media and Tissues, (International Society for Optics and Photonics, 1993), 78–89.

A. Koenig, B. Roig, J. Le Digabel, G. Josse, and J.-M. Dinten, “Accessing deep optical properties of skin using diffuse reflectance spectroscopy,” in European Conference on Biomedical Optics, (Optical Society of America, 2015), 95370E.

L. L. de Boer, E. Kho, F. van Duijnhoven, M.-J. T. V. Peeters, K. K. Van de Vijver, B. H. Hendriks, H. J. Sterenborg, and T. J. Ruers, “Towards detection of positive resection margins with diffuse reflectance spectroscopy during breast conserving surgery (Conference Presentation),” in Diseases in the Breast and Reproductive System V, (International Society for Optics and Photonics, 2019), 108560H.

M. Pilewskie and M. Morrow, “Extent and role of margin control for DCIS managed by breast-conserving surgery,” in Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer (Springer, 2015), pp. 67–83.

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Figures (6)

Fig. 1.
Fig. 1. A) The design of the electrosurgical knife integrated with DRS (fiber-fiber distance = 3 mm). B) Characterizing the debris formed on the tip of optical fibers due to electrosurgery. C) The used setup to measure the intensity of light passing through the clean and used optical fibers. D) The setup to investigate the DRS signal deterioration after electrosurgery with three different sets of optical fiber, Clean Fiber (unused fiber), Muscle Fiber (contaminated with muscle tissue), and Fat Fiber (contaminated with adipose tissue) on three different surfaces (white reference, porcine muscle, and porcine adipose tissue).
Fig. 2.
Fig. 2. The shape and morphology of the optical fibers before and after electrosurgery, investigated by optical microscopy (second row) and scanning electron microscopy (SEM, third row).
Fig. 3.
Fig. 3. EDX (energy-dispersive spectroscopy) results taken from the tip of Clean Fiber, Muscle Fiber, and Fat Fiber.
Fig. 4.
Fig. 4. (A) a side view picture of a used optical fiber integrated into the electrosurgical knife. (B) Raman spectrum is taken from the acrylate coating of clean optical fiber.
Fig. 5.
Fig. 5. Fitted spectra using Clean Fiber, Muscle Fiber and Fat fiber in front of the (A) white reference, (B) in contact with muscle tissue and (C) in contact with adipose tissue.
Fig. 6.
Fig. 6. The concentration of chromophores derived from the obtained spectra using Clean Fiber (black), Muscle Fiber (green) and Fat Fiber (red).

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