Abstract

New quantitative prognostic markers are needed for improved pancreatic ductal adenocarcinoma (PDAC) prognosis. Second harmonic generation microscopy has been used to show that collagen fiber alignment in PDAC is a negative prognostic factor. In this work, a series of PDAC and normal adjacent tissue (NAT) biopsies were imaged with spatial light interference microscopy (SLIM). Quantitative analysis performed on the biopsy SLIM images show that PDAC fiber structures have lower alignment per unit length, narrower width, and are longer than NAT controls. Importantly, fibrillar collagen in PDAC shows an inverse relationship between survival data and fiber width and length (p < 0.05).

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2019 (2)

C. Hu and G. Popescu, “Quantitative Phase Imaging (QPI) in Neuroscience,” IEEE J. Sel. Top. Quantum Electron. 25(1), 1–9 (2019).
[Crossref]

C. Hu, M. Santi, O. Adelaja, A. Kajdacsy-Balla, G. Popescu, and W. Kobak, “Imaging collagen properties in the uterosacral ligaments of women with pelvic organ prolapse using spatial light interference microscopy (SLIM),” Front. Phys. 7, 72 (2019).
[Crossref]

2018 (1)

M. Takabayashi, H. Majeed, A. Kajdacsy-Balla, and G. Popescu, “Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies,” PLoS One 13(3), e0194320 (2018).
[Crossref]

2017 (5)

M. E. Kandel, S. Sridharan, J. Liang, Z. Luo, K. Han, V. Macias, A. Shah, R. Patel, K. Tangella, and A. Kajdacsy-Balla, “Label-free tissue scanner for colorectal cancer screening,” J. Biomed. Opt. 22(6), 066016 (2017).
[Crossref]

T. H. Nguyen, S. Sridharan, V. Macias, A. Kajdacsy-Balla, J. Melamed, M. N. Do, and G. Popescu, “Automatic Gleason grading of prostate cancer using quantitative phase imaging and machine learning,” J. Biomed. Opt. 22(3), 036015 (2017).
[Crossref]

H. Majeed, S. Sridharan, M. Mir, L. Ma, E. Min, W. Jung, and G. Popescu, “Quantitative phase imaging for medical diagnosis,” J. Biophotonics 10(2), 177–205 (2017).
[Crossref]

A. Keikhosravi, Y. Liu, C. Drifka, K. M. Woo, A. Verma, R. Oldenbourg, and K. W. Eliceiri, “Quantification of collagen organization in histopathology samples using liquid crystal based polarization microscopy,” Biomed. Opt. Express 8(9), 4243–4256 (2017).
[Crossref]

H. Majeed, C. Okoro, A. Kajdacsy-Balla, J. K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref]

2016 (4)

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci. Rep. 6(1), 31034 (2016).
[Crossref]

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
[Crossref]

C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
[Crossref]

H. S. Park, M. Rinehart, K. A. Walzer, J. T. A. Chi, and A. Wax, “Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells,” PLoS One 11(9), e0163045 (2016).
[Crossref]

2015 (7)

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
[Crossref]

L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer J. Clin. 65(2), 87–108 (2015).
[Crossref]

K. M. Bever, E. A. Sugar, E. Bigelow, R. Sharma, D. Laheru, C. L. Wolfgang, E. M. Jaffee, R. A. Anders, A. De Jesus-Acosta, and L. Zheng, “The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy,” HPB 17(4), 292–298 (2015).
[Crossref]

J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
[Crossref]

C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5(1), 9976 (2015).
[Crossref]

H. Majeed, M. E. Kandel, K. Han, Z. Luo, V. Macias, K. V. Tangella, A. Balla, and G. Popescu, “Breast cancer diagnosis using spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111210 (2015).
[Crossref]

2014 (2)

J. S. Bredfeldt, Y. Liu, C. A. Pehlke, M. W. Conklin, J. M. Szulczewski, D. R. Inman, P. J. Keely, R. D. Nowak, T. R. Mackie, and K. W. Eliceiri, “Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer,” J. Biomed. Opt. 19(1), 016007 (2014).
[Crossref]

L. Rahib, B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian, “Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States,” Cancer Res. 74(11), 2913–2921 (2014).
[Crossref]

2013 (1)

M. Sinn, J. K. Striefler, B. V. Sinn, D. Sallmon, S. Bischoff, J. M. Stieler, U. Pelzer, M. Bahra, P. Neuhaus, and B. Dörken, “Does long-term survival in patients with pancreatic cancer really exist?—Results from the CONKO-001 study,” J. Surg. Oncol. 108(6), 398–402 (2013).
[Crossref]

2012 (2)

A. D. Rhim, E. T. Mirek, N. M. Aiello, A. Maitra, J. M. Bailey, F. McAllister, M. Reichert, G. L. Beatty, A. K. Rustgi, and R. H. Vonderheide, “EMT and dissemination precede pancreatic tumor formation,” Cell 148(1-2), 349–361 (2012).
[Crossref]

M. M. Mukaka, “A guide to appropriate use of correlation coefficient in medical research,” Malawi Med. J. 24(3), 69–71 (2012).

2011 (2)

R. K. Jain, R. Mehta, R. Dimitrov, L. G. Larsson, P. M. Musto, K. B. Hodges, T. M. Ulbright, E. M. Hattab, N. Agaram, and M. T. Idrees, “Atypical ductal hyperplasia: interobserver and intraobserver variability,” Mod. Pathol. 24(7), 917–923 (2011).
[Crossref]

Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[Crossref]

2010 (2)

P. Wang, R. Bista, R. Bhargava, R. E. Brand, and Y. Liu, “Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis,” Opt. Lett. 35(17), 2840–2842 (2010).
[Crossref]

O. Nadiarnykh, R. B. LaComb, M. A. Brewer, and P. J. Campagnola, “Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy,” BMC Cancer 10(1), 94 (2010).
[Crossref]

2009 (3)

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

A. Blackford, O. K. Serrano, C. L. Wolfgang, G. Parmigiani, S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, and J. R. Eshleman, “SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer,” Clin. Cancer Res. 15(14), 4674–4679 (2009).
[Crossref]

S. Pandol, M. Edderkaoui, I. Gukovsky, A. Lugea, and A. Gukovskaya, “Desmoplasia of pancreatic ductal adenocarcinoma,” Clin. Gastroenterol. Hepatol. 7(11), S44–S47 (2009).
[Crossref]

2008 (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref]

2007 (1)

K. M. Yamada and E. Cukierman, “Modeling tissue morphogenesis and cancer in 3D,” Cell 130(4), 601–610 (2007).
[Crossref]

2006 (1)

P. P. Provenzano, K. W. Eliceiri, J. M. Campbell, D. R. Inman, J. G. White, and P. J. Keely, “Collagen reorganization at the tumor-stromal interface facilitates local invasion,” BMC Med. 4(1), 38 (2006).
[Crossref]

2004 (1)

M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

2003 (2)

A. Richter, M. Niedergethmann, J. W. Sturm, D. Lorenz, S. Post, and M. Trede, “Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience,” World J. Surg. 27(3), 324–329 (2003).
[Crossref]

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
[Crossref]

2002 (1)

S. Rickes, K. Unkrodt, H. Neye, K. Ocran, and W. Wermke, “Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography,” Scand. J. Gastroenterol. 37(11), 1313–1320 (2002).
[Crossref]

2000 (2)

B. Brand, T. Pfaff, K. Binmoeller, P. Sriram, A. Fritscher-Ravens, W. Knöfel, S. Jäckle, and N. Soehendra, “Endoscopic ultrasound for differential diagnosis of focal pancreatic lesions, confirmed by surgery,” Scand. J. Gastroenterol. 35(11), 1221–1228 (2000).
[Crossref]

A. Sendler, N. Avril, H. Helmberger, J. Stollfuß, W. Weber, F. Bengel, M. Schwaiger, J. D. Roder, and J. R. Siewert, “Preoperative evaluation of pancreatic masses with positron emission tomography using 18 F-fluorodeoxyglucose: diagnostic limitations,” World J. Surg. 24(9), 1121–1129 (2000).
[Crossref]

1999 (1)

S. J. Diehl, K. J. Lehmann, J. Gaa, S. McGill, V. Hoffmann, and M. Georgi, “MR imaging of pancreatic lesions: comparison of manganese-DPDP and gadolinium chelate,” Invest. Radiol. 34(9), 589 (1999).
[Crossref]

1997 (1)

K. J. Chang, P. Nguyen, R. A. Erickson, T. E. Durbin, and K. D. Katz, “The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma,” Gastrointest. Endosc. 45(5), 387–393 (1997).
[Crossref]

1996 (1)

D. Lu, S. Vedantham, R. M. Krasny, B. Kadell, W. L. Berger, and H. A. Reber, “Two-phase helical CT for pancreatic tumors: pancreatic versus hepatic phase enhancement of tumor, pancreas, and vascular structures,” Radiology 199(3), 697–701 (1996).
[Crossref]

1995 (1)

R. Oldenbourg and G. Mei, “New polarized light microscope with precision universal compensator,” J. Microsc. 180(2), 140–147 (1995).
[Crossref]

Adelaja, O.

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L. Rahib, B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian, “Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States,” Cancer Res. 74(11), 2913–2921 (2014).
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H. Majeed, M. E. Kandel, K. Han, Z. Luo, V. Macias, K. V. Tangella, A. Balla, and G. Popescu, “Breast cancer diagnosis using spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111210 (2015).
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K. M. Bever, E. A. Sugar, E. Bigelow, R. Sharma, D. Laheru, C. L. Wolfgang, E. M. Jaffee, R. A. Anders, A. De Jesus-Acosta, and L. Zheng, “The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy,” HPB 17(4), 292–298 (2015).
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B. Brand, T. Pfaff, K. Binmoeller, P. Sriram, A. Fritscher-Ravens, W. Knöfel, S. Jäckle, and N. Soehendra, “Endoscopic ultrasound for differential diagnosis of focal pancreatic lesions, confirmed by surgery,” Scand. J. Gastroenterol. 35(11), 1221–1228 (2000).
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Brand, R. E.

Bray, F.

L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer J. Clin. 65(2), 87–108 (2015).
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K. J. Chang, P. Nguyen, R. A. Erickson, T. E. Durbin, and K. D. Katz, “The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma,” Gastrointest. Endosc. 45(5), 387–393 (1997).
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M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

Chhieng, D. C.

M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

Chi, J. T. A.

H. S. Park, M. Rinehart, K. A. Walzer, J. T. A. Chi, and A. Wax, “Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells,” PLoS One 11(9), e0163045 (2016).
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J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
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J. S. Bredfeldt, Y. Liu, C. A. Pehlke, M. W. Conklin, J. M. Szulczewski, D. R. Inman, P. J. Keely, R. D. Nowak, T. R. Mackie, and K. W. Eliceiri, “Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer,” J. Biomed. Opt. 19(1), 016007 (2014).
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Couvelard, A.

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
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Cros, J.

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
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K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
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K. M. Yamada and E. Cukierman, “Modeling tissue morphogenesis and cancer in 3D,” Cell 130(4), 601–610 (2007).
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G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref]

De Jesus-Acosta, A.

K. M. Bever, E. A. Sugar, E. Bigelow, R. Sharma, D. Laheru, C. L. Wolfgang, E. M. Jaffee, R. A. Anders, A. De Jesus-Acosta, and L. Zheng, “The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy,” HPB 17(4), 292–298 (2015).
[Crossref]

Deflores, L.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref]

Desai, S. R.

J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
[Crossref]

Diehl, S. J.

S. J. Diehl, K. J. Lehmann, J. Gaa, S. McGill, V. Hoffmann, and M. Georgi, “MR imaging of pancreatic lesions: comparison of manganese-DPDP and gadolinium chelate,” Invest. Radiol. 34(9), 589 (1999).
[Crossref]

Dimitrov, R.

R. K. Jain, R. Mehta, R. Dimitrov, L. G. Larsson, P. M. Musto, K. B. Hodges, T. M. Ulbright, E. M. Hattab, N. Agaram, and M. T. Idrees, “Atypical ductal hyperplasia: interobserver and intraobserver variability,” Mod. Pathol. 24(7), 917–923 (2011).
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Ding, H.

Do, M. N.

T. H. Nguyen, S. Sridharan, V. Macias, A. Kajdacsy-Balla, J. Melamed, M. N. Do, and G. Popescu, “Automatic Gleason grading of prostate cancer using quantitative phase imaging and machine learning,” J. Biomed. Opt. 22(3), 036015 (2017).
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Dörken, B.

M. Sinn, J. K. Striefler, B. V. Sinn, D. Sallmon, S. Bischoff, J. M. Stieler, U. Pelzer, M. Bahra, P. Neuhaus, and B. Dörken, “Does long-term survival in patients with pancreatic cancer really exist?—Results from the CONKO-001 study,” J. Surg. Oncol. 108(6), 398–402 (2013).
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Drifka, C.

A. Keikhosravi, Y. Liu, C. Drifka, K. M. Woo, A. Verma, R. Oldenbourg, and K. W. Eliceiri, “Quantification of collagen organization in histopathology samples using liquid crystal based polarization microscopy,” Biomed. Opt. Express 8(9), 4243–4256 (2017).
[Crossref]

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
[Crossref]

Drifka, C. R.

C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
[Crossref]

C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

Durbin, T. E.

K. J. Chang, P. Nguyen, R. A. Erickson, T. E. Durbin, and K. D. Katz, “The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma,” Gastrointest. Endosc. 45(5), 387–393 (1997).
[Crossref]

Edderkaoui, M.

S. Pandol, M. Edderkaoui, I. Gukovsky, A. Lugea, and A. Gukovskaya, “Desmoplasia of pancreatic ductal adenocarcinoma,” Clin. Gastroenterol. Hepatol. 7(11), S44–S47 (2009).
[Crossref]

Egeblad, M.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

Eickhoff, J. C.

C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
[Crossref]

Eliceiri, K. W.

A. Keikhosravi, Y. Liu, C. Drifka, K. M. Woo, A. Verma, R. Oldenbourg, and K. W. Eliceiri, “Quantification of collagen organization in histopathology samples using liquid crystal based polarization microscopy,” Biomed. Opt. Express 8(9), 4243–4256 (2017).
[Crossref]

C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
[Crossref]

C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
[Crossref]

J. S. Bredfeldt, Y. Liu, C. A. Pehlke, M. W. Conklin, J. M. Szulczewski, D. R. Inman, P. J. Keely, R. D. Nowak, T. R. Mackie, and K. W. Eliceiri, “Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer,” J. Biomed. Opt. 19(1), 016007 (2014).
[Crossref]

P. P. Provenzano, K. W. Eliceiri, J. M. Campbell, D. R. Inman, J. G. White, and P. J. Keely, “Collagen reorganization at the tumor-stromal interface facilitates local invasion,” BMC Med. 4(1), 38 (2006).
[Crossref]

Eloubeidi, M. A.

M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

Eltoum, I.

M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

Erickson, R. A.

K. J. Chang, P. Nguyen, R. A. Erickson, T. E. Durbin, and K. D. Katz, “The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma,” Gastrointest. Endosc. 45(5), 387–393 (1997).
[Crossref]

Erler, J. T.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

Eshleman, J. R.

A. Blackford, O. K. Serrano, C. L. Wolfgang, G. Parmigiani, S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, and J. R. Eshleman, “SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer,” Clin. Cancer Res. 15(14), 4674–4679 (2009).
[Crossref]

Feld, M. S.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref]

Ferlay, J.

L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer J. Clin. 65(2), 87–108 (2015).
[Crossref]

Fleshman, J. M.

L. Rahib, B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian, “Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States,” Cancer Res. 74(11), 2913–2921 (2014).
[Crossref]

Fong, S. F.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

Fritscher-Ravens, A.

B. Brand, T. Pfaff, K. Binmoeller, P. Sriram, A. Fritscher-Ravens, W. Knöfel, S. Jäckle, and N. Soehendra, “Endoscopic ultrasound for differential diagnosis of focal pancreatic lesions, confirmed by surgery,” Scand. J. Gastroenterol. 35(11), 1221–1228 (2000).
[Crossref]

Gaa, J.

S. J. Diehl, K. J. Lehmann, J. Gaa, S. McGill, V. Hoffmann, and M. Georgi, “MR imaging of pancreatic lesions: comparison of manganese-DPDP and gadolinium chelate,” Invest. Radiol. 34(9), 589 (1999).
[Crossref]

Georgi, M.

S. J. Diehl, K. J. Lehmann, J. Gaa, S. McGill, V. Hoffmann, and M. Georgi, “MR imaging of pancreatic lesions: comparison of manganese-DPDP and gadolinium chelate,” Invest. Radiol. 34(9), 589 (1999).
[Crossref]

Giaccia, A.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

Gillette, M. U.

Gukovskaya, A.

S. Pandol, M. Edderkaoui, I. Gukovsky, A. Lugea, and A. Gukovskaya, “Desmoplasia of pancreatic ductal adenocarcinoma,” Clin. Gastroenterol. Hepatol. 7(11), S44–S47 (2009).
[Crossref]

Gukovsky, I.

S. Pandol, M. Edderkaoui, I. Gukovsky, A. Lugea, and A. Gukovskaya, “Desmoplasia of pancreatic ductal adenocarcinoma,” Clin. Gastroenterol. Hepatol. 7(11), S44–S47 (2009).
[Crossref]

Hammel, P.

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
[Crossref]

Han, K.

M. E. Kandel, S. Sridharan, J. Liang, Z. Luo, K. Han, V. Macias, A. Shah, R. Patel, K. Tangella, and A. Kajdacsy-Balla, “Label-free tissue scanner for colorectal cancer screening,” J. Biomed. Opt. 22(6), 066016 (2017).
[Crossref]

H. Majeed, M. E. Kandel, K. Han, Z. Luo, V. Macias, K. V. Tangella, A. Balla, and G. Popescu, “Breast cancer diagnosis using spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111210 (2015).
[Crossref]

Hanley, C. J.

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
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T. H. Nguyen, S. Sridharan, V. Macias, A. Kajdacsy-Balla, J. Melamed, M. N. Do, and G. Popescu, “Automatic Gleason grading of prostate cancer using quantitative phase imaging and machine learning,” J. Biomed. Opt. 22(3), 036015 (2017).
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M. E. Kandel, S. Sridharan, J. Liang, Z. Luo, K. Han, V. Macias, A. Shah, R. Patel, K. Tangella, and A. Kajdacsy-Balla, “Label-free tissue scanner for colorectal cancer screening,” J. Biomed. Opt. 22(6), 066016 (2017).
[Crossref]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5(1), 9976 (2015).
[Crossref]

Tangella, K. V.

H. Majeed, M. E. Kandel, K. Han, Z. Luo, V. Macias, K. V. Tangella, A. Balla, and G. Popescu, “Breast cancer diagnosis using spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111210 (2015).
[Crossref]

Thirdborough, S.

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
[Crossref]

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C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

Tijeras-Raballand, A.

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
[Crossref]

Tod, J.

C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

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L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer J. Clin. 65(2), 87–108 (2015).
[Crossref]

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C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
[Crossref]

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H. Majeed, C. Okoro, A. Kajdacsy-Balla, J. K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref]

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A. Richter, M. Niedergethmann, J. W. Sturm, D. Lorenz, S. Post, and M. Trede, “Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience,” World J. Surg. 27(3), 324–329 (2003).
[Crossref]

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J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
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[Crossref]

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C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
[Crossref]

Walzer, K. A.

H. S. Park, M. Rinehart, K. A. Walzer, J. T. A. Chi, and A. Wax, “Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells,” PLoS One 11(9), e0163045 (2016).
[Crossref]

Wang, P.

Wang, Z.

Ward, M.

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
[Crossref]

Wax, A.

H. S. Park, M. Rinehart, K. A. Walzer, J. T. A. Chi, and A. Wax, “Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells,” PLoS One 11(9), e0163045 (2016).
[Crossref]

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J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
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C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
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Weber, W.

A. Sendler, N. Avril, H. Helmberger, J. Stollfuß, W. Weber, F. Bengel, M. Schwaiger, J. D. Roder, and J. R. Siewert, “Preoperative evaluation of pancreatic masses with positron emission tomography using 18 F-fluorodeoxyglucose: diagnostic limitations,” World J. Surg. 24(9), 1121–1129 (2000).
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S. Rickes, K. Unkrodt, H. Neye, K. Ocran, and W. Wermke, “Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography,” Scand. J. Gastroenterol. 37(11), 1313–1320 (2002).
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M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci. Rep. 6(1), 31034 (2016).
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Yu, H.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci. Rep. 6(1), 31034 (2016).
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K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
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A. Blackford, O. K. Serrano, C. L. Wolfgang, G. Parmigiani, S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, and J. R. Eshleman, “SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer,” Clin. Cancer Res. 15(14), 4674–4679 (2009).
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K. M. Bever, E. A. Sugar, E. Bigelow, R. Sharma, D. Laheru, C. L. Wolfgang, E. M. Jaffee, R. A. Anders, A. De Jesus-Acosta, and L. Zheng, “The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy,” HPB 17(4), 292–298 (2015).
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Am. J. Physiol. Cell Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
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Biomed. Opt. Express (1)

BMC Cancer (1)

O. Nadiarnykh, R. B. LaComb, M. A. Brewer, and P. J. Campagnola, “Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy,” BMC Cancer 10(1), 94 (2010).
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BMC Med. (1)

P. P. Provenzano, K. W. Eliceiri, J. M. Campbell, D. R. Inman, J. G. White, and P. J. Keely, “Collagen reorganization at the tumor-stromal interface facilitates local invasion,” BMC Med. 4(1), 38 (2006).
[Crossref]

CA Cancer J. Clin. (2)

L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer J. Clin. 65(2), 87–108 (2015).
[Crossref]

M. R. Vander Noot, M. A. Eloubeidi, V. K. Chen, I. Eltoum, D. Jhala, N. Jhala, S. Syed, and D. C. Chhieng, “Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy,” CA Cancer J. Clin. 102(3), 157–163 (2004).

Cancer Res. (1)

L. Rahib, B. D. Smith, R. Aizenberg, A. B. Rosenzweig, J. M. Fleshman, and L. M. Matrisian, “Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States,” Cancer Res. 74(11), 2913–2921 (2014).
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Cell (3)

A. D. Rhim, E. T. Mirek, N. M. Aiello, A. Maitra, J. M. Bailey, F. McAllister, M. Reichert, G. L. Beatty, A. K. Rustgi, and R. H. Vonderheide, “EMT and dissemination precede pancreatic tumor formation,” Cell 148(1-2), 349–361 (2012).
[Crossref]

K. M. Yamada and E. Cukierman, “Modeling tissue morphogenesis and cancer in 3D,” Cell 130(4), 601–610 (2007).
[Crossref]

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad, J. T. Erler, S. F. Fong, K. Csiszar, A. Giaccia, and W. Weninger, “Matrix crosslinking forces tumor progression by enhancing integrin signaling,” Cell 139(5), 891–906 (2009).
[Crossref]

Clin. Cancer Res. (1)

A. Blackford, O. K. Serrano, C. L. Wolfgang, G. Parmigiani, S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, and J. R. Eshleman, “SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer,” Clin. Cancer Res. 15(14), 4674–4679 (2009).
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Clin. Gastroenterol. Hepatol. (1)

S. Pandol, M. Edderkaoui, I. Gukovsky, A. Lugea, and A. Gukovskaya, “Desmoplasia of pancreatic ductal adenocarcinoma,” Clin. Gastroenterol. Hepatol. 7(11), S44–S47 (2009).
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Free Radical Biol. Med. (1)

J. C. Tung, J. M. Barnes, S. R. Desai, C. Sistrunk, M. W. Conklin, P. Schedin, K. W. Eliceiri, P. J. Keely, V. L. Seewaldt, and V. M. Weaver, “Tumor mechanics and metabolic dysfunction,” Free Radical Biol. Med. 79, 269–280 (2015).
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Front. Phys. (1)

C. Hu, M. Santi, O. Adelaja, A. Kajdacsy-Balla, G. Popescu, and W. Kobak, “Imaging collagen properties in the uterosacral ligaments of women with pelvic organ prolapse using spatial light interference microscopy (SLIM),” Front. Phys. 7, 72 (2019).
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Gastrointest. Endosc. (1)

K. J. Chang, P. Nguyen, R. A. Erickson, T. E. Durbin, and K. D. Katz, “The clinical utility of endoscopic ultrasound–guided fine-needle aspiration in the diagnosisand staging of pancreatic carcinoma,” Gastrointest. Endosc. 45(5), 387–393 (1997).
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HPB (1)

K. M. Bever, E. A. Sugar, E. Bigelow, R. Sharma, D. Laheru, C. L. Wolfgang, E. M. Jaffee, R. A. Anders, A. De Jesus-Acosta, and L. Zheng, “The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy,” HPB 17(4), 292–298 (2015).
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IEEE J. Sel. Top. Quantum Electron. (1)

C. Hu and G. Popescu, “Quantitative Phase Imaging (QPI) in Neuroscience,” IEEE J. Sel. Top. Quantum Electron. 25(1), 1–9 (2019).
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Invest. Radiol. (1)

S. J. Diehl, K. J. Lehmann, J. Gaa, S. McGill, V. Hoffmann, and M. Georgi, “MR imaging of pancreatic lesions: comparison of manganese-DPDP and gadolinium chelate,” Invest. Radiol. 34(9), 589 (1999).
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J. Biomed. Opt. (5)

J. S. Bredfeldt, Y. Liu, C. A. Pehlke, M. W. Conklin, J. M. Szulczewski, D. R. Inman, P. J. Keely, R. D. Nowak, T. R. Mackie, and K. W. Eliceiri, “Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer,” J. Biomed. Opt. 19(1), 016007 (2014).
[Crossref]

H. Majeed, C. Okoro, A. Kajdacsy-Balla, J. K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref]

H. Majeed, M. E. Kandel, K. Han, Z. Luo, V. Macias, K. V. Tangella, A. Balla, and G. Popescu, “Breast cancer diagnosis using spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111210 (2015).
[Crossref]

T. H. Nguyen, S. Sridharan, V. Macias, A. Kajdacsy-Balla, J. Melamed, M. N. Do, and G. Popescu, “Automatic Gleason grading of prostate cancer using quantitative phase imaging and machine learning,” J. Biomed. Opt. 22(3), 036015 (2017).
[Crossref]

M. E. Kandel, S. Sridharan, J. Liang, Z. Luo, K. Han, V. Macias, A. Shah, R. Patel, K. Tangella, and A. Kajdacsy-Balla, “Label-free tissue scanner for colorectal cancer screening,” J. Biomed. Opt. 22(6), 066016 (2017).
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J. Biophotonics (1)

H. Majeed, S. Sridharan, M. Mir, L. Ma, E. Min, W. Jung, and G. Popescu, “Quantitative phase imaging for medical diagnosis,” J. Biophotonics 10(2), 177–205 (2017).
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Malawi Med. J. (1)

M. M. Mukaka, “A guide to appropriate use of correlation coefficient in medical research,” Malawi Med. J. 24(3), 69–71 (2012).

Mod. Pathol. (2)

C. R. Drifka, J. Tod, A. G. Loeffler, Y. Liu, G. J. Thomas, K. W. Eliceiri, and W. J. Kao, “Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis,” Mod. Pathol. 28(11), 1470–1480 (2015).
[Crossref]

R. K. Jain, R. Mehta, R. Dimitrov, L. G. Larsson, P. M. Musto, K. B. Hodges, T. M. Ulbright, E. M. Hattab, N. Agaram, and M. T. Idrees, “Atypical ductal hyperplasia: interobserver and intraobserver variability,” Mod. Pathol. 24(7), 917–923 (2011).
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Nat. Biotechnol. (1)

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
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Oncotarget (2)

C. J. Hanley, F. Noble, M. Ward, M. Bullock, C. Drifka, M. Mellone, A. Manousopoulou, H. E. Johnston, A. Hayden, and S. Thirdborough, “A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers,” Oncotarget 7(5), 6159 (2016).
[Crossref]

C. R. Drifka, A. G. Loeffler, K. Mathewson, A. Keikhosravi, J. C. Eickhoff, Y. Liu, S. M. Weber, W. J. Kao, and K. W. Eliceiri, “Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection,” Oncotarget 7(46), 76197 (2016).
[Crossref]

Opt. Express (1)

Opt. Lett. (1)

Pharmacol. Ther. (1)

C. Neuzillet, A. Tijeras-Raballand, P. Bourget, J. Cros, A. Couvelard, A. Sauvanet, M.-P. Vullierme, C. Tournigand, and P. Hammel, “State of the art and future directions of pancreatic ductal adenocarcinoma therapy,” Pharmacol. Ther. 155, 80–104 (2015).
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PLoS One (2)

M. Takabayashi, H. Majeed, A. Kajdacsy-Balla, and G. Popescu, “Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies,” PLoS One 13(3), e0194320 (2018).
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H. S. Park, M. Rinehart, K. A. Walzer, J. T. A. Chi, and A. Wax, “Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells,” PLoS One 11(9), e0163045 (2016).
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Radiology (1)

D. Lu, S. Vedantham, R. M. Krasny, B. Kadell, W. L. Berger, and H. A. Reber, “Two-phase helical CT for pancreatic tumors: pancreatic versus hepatic phase enhancement of tumor, pancreas, and vascular structures,” Radiology 199(3), 697–701 (1996).
[Crossref]

Scand. J. Gastroenterol. (2)

S. Rickes, K. Unkrodt, H. Neye, K. Ocran, and W. Wermke, “Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography,” Scand. J. Gastroenterol. 37(11), 1313–1320 (2002).
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B. Brand, T. Pfaff, K. Binmoeller, P. Sriram, A. Fritscher-Ravens, W. Knöfel, S. Jäckle, and N. Soehendra, “Endoscopic ultrasound for differential diagnosis of focal pancreatic lesions, confirmed by surgery,” Scand. J. Gastroenterol. 35(11), 1221–1228 (2000).
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Sci. Rep. (2)

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci. Rep. 6(1), 31034 (2016).
[Crossref]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5(1), 9976 (2015).
[Crossref]

World J. Surg. (2)

A. Richter, M. Niedergethmann, J. W. Sturm, D. Lorenz, S. Post, and M. Trede, “Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience,” World J. Surg. 27(3), 324–329 (2003).
[Crossref]

A. Sendler, N. Avril, H. Helmberger, J. Stollfuß, W. Weber, F. Bengel, M. Schwaiger, J. D. Roder, and J. R. Siewert, “Preoperative evaluation of pancreatic masses with positron emission tomography using 18 F-fluorodeoxyglucose: diagnostic limitations,” World J. Surg. 24(9), 1121–1129 (2000).
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Other (1)

G. Popescu, Quantitative phase imaging of cells and tissues, McGraw Hill Professional (2011).

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Figures (8)

Fig. 1.
Fig. 1. Schematic for SLIM. The SLIM module is attached to a commercial phase contrast microscope (Nikon Eclipse Ti).
Fig. 2.
Fig. 2. Stitched SLIM images of the whole TMA slide (Hpan-Ade180Sur-01) (A). SLIM images of PDAC/NAT biopsy cores (scale bar 50 µm) (B-D). Corresponding CT-Fire mapping of fibers for D (E).
Fig. 3.
Fig. 3. Stitched brightfield H&E images of whole pancreas biopsy cores (Hpan-Ade180Sur-01). NAT pancreatic core with insets showing zoomed in regions of a duct, acini, a vein, and Islets of Langerhans (A). Corresponding patient PDAC core, with inset showing the characteristic dense desmoplastic stroma (B).
Fig. 4.
Fig. 4. Histograms (log) of both normal adjacent tissue (NAT) and pancreatic ductal adenocarcinoma (PDAC) fiber angle/length (A), fiber width (B), fiber length (C), and fiber straightness (D) of individual fibers across all cores.
Fig. 5.
Fig. 5. Plot of first two principal components of mean width, straightness, length, alignment/length fiber parameters, as well as dry mass density for PDAC and NAT cores, with decision boundary (A). ROC curves for discriminating cancerous tissue based on mean fiber length, alignment/length, straightness, and width (B).
Fig. 6.
Fig. 6. Kaplan-Meier survival curves for pancreatic ductal adenocarcinoma (PDAC), comparing different grades of fiber alignment/length (A), fiber width (B), fiber length (C), and fiber straightness (D). Log-Rank ${\boldsymbol{\chi }^2}$ of 50.7 (str), 37.43 (width), 25.7 (al), 50.8 (length).
Fig. 7.
Fig. 7. Difference between stage groups 1 A-B and 2 A-B in pancreatic ductal adenocarcinoma (PDAC) fiber alignment (A), fiber width (B), fiber length (C), and fiber straightness (D). p-values are 0.36, 0.98, 0.184, 0.31, respectively.
Fig. 8.
Fig. 8. Kaplan-Meier survival curves for normal adjacent tissue (NAT), comparing different grades of fiber alignment (A), fiber width (B), fiber length (C), and fiber straightness (D). Log-Rank ${\boldsymbol{\chi }^2}$ of 38.61 (str), 37.43 (width), 21.9 (al), 44.15 (length).