Abstract

Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  34. H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
    [Crossref] [PubMed]
  35. M. Singh, C. Wu, C. H. Liu, J. Li, A. Schill, A. Nair, and K. V. Larin, “Phase-sensitive optical coherence elastography at 1.5 million A-Lines per second,” Opt. Lett. 40(11), 2588–2591 (2015).
    [Crossref] [PubMed]

2019 (2)

2018 (3)

2017 (5)

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref] [PubMed]

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

2016 (4)

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

2015 (5)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. I. Akca, E. W. Chang, S. Kling, A. Ramier, G. Scarcelli, S. Marcos, and S. H. Yun, “Observation of sound-induced corneal vibrational modes by optical coherence tomography,” Biomed. Opt. Express 6(9), 3313–3319 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

M. Singh, C. Wu, C. H. Liu, J. Li, A. Schill, A. Nair, and K. V. Larin, “Phase-sensitive optical coherence elastography at 1.5 million A-Lines per second,” Opt. Lett. 40(11), 2588–2591 (2015).
[Crossref] [PubMed]

2014 (5)

2013 (2)

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

K. Y. Ha, P. Deleon, and W. Deleon, “Invasive mucinous carcinoma of the breast,” Proc. Bayl. Univ. Med. Cent. 26(3), 295–297 (2013).
[Crossref] [PubMed]

2012 (3)

2011 (1)

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

2010 (1)

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

2009 (1)

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

2007 (1)

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

2003 (1)

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Abbad, F.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Abdel Razek, N. M.

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

Adie, S. G.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Akca, B. I.

Alaoui M’hamdi, H.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Allen, W. M.

Asmouki, H.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Athwal, A.

Ballal, H.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Belbaraka, R.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Bellafiore, F. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bergers, E.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Bisaillon, C.-E.

Boppart, S. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bosch, A. M.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Bourke, A. G.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Brown, C. N.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Caddy, C. M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Cai, H.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Campbell, G.

Chammas, M. C.

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

Chandrasekaran, S. N.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Chaney, E. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Chang, E. W.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chapellier, C.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Chin, L.

M. S. Hepburn, P. Wijesinghe, L. Chin, and B. F. Kennedy, “Analysis of spatial resolution in phase-sensitive compression optical coherence elastography,” Biomed. Opt. Express 10(3), 1496–1513 (2019).
[Crossref] [PubMed]

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Chin, S. L.

Cromwell, D. A.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Curatolo, A.

B. Krajancich, A. Curatolo, Q. Fang, R. Zilkens, B. F. Dessauvagie, C. M. Saunders, and B. F. Kennedy, “Handheld optical palpation of turbid tissue with motion-artifact correction,” Biomed. Opt. Express 10(1), 226–241 (2019).
[Crossref] [PubMed]

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

de Lange de Klerk, E. S. M.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

de Paredes, E. S.

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

de Widt-Levert, L. M.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

de Wit, R. H.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Deleon, P.

K. Y. Ha, P. Deleon, and W. Deleon, “Invasive mucinous carcinoma of the breast,” Proc. Bayl. Univ. Med. Cent. 26(3), 295–297 (2013).
[Crossref] [PubMed]

Deleon, W.

K. Y. Ha, P. Deleon, and W. Deleon, “Invasive mucinous carcinoma of the breast,” Proc. Bayl. Univ. Med. Cent. 26(3), 295–297 (2013).
[Crossref] [PubMed]

Dessauvagie, B. F.

Doherty, R. D.

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

Ehman, R. L.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

Es’haghian, S.

Fajardo, L. L.

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Fang, Q.

Ferrero, J. M.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Flipo, B.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fouche, Y.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Franken, E. A.

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Glaser, K. J.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

Gong, P.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ha, K. Y.

K. Y. Ha, P. Deleon, and W. Deleon, “Invasive mucinous carcinoma of the breast,” Proc. Bayl. Univ. Med. Cent. 26(3), 295–297 (2013).
[Crossref] [PubMed]

Haloua, M. H.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Hassan, M. A. G.

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Heisler, M.

Hepburn, M. S.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ihrai, T.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Jasiówka, M.

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Jeevan, R.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Jian, Y.

Jin, C.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Johnson, P. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Ju, M. J.

Kaffas, A. E.

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

Kamal, R. M.

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

Kearins, O.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Kennedy, B. F.

M. S. Hepburn, P. Wijesinghe, L. Chin, and B. F. Kennedy, “Analysis of spatial resolution in phase-sensitive compression optical coherence elastography,” Biomed. Opt. Express 10(3), 1496–1513 (2019).
[Crossref] [PubMed]

B. Krajancich, A. Curatolo, Q. Fang, R. Zilkens, B. F. Dessauvagie, C. M. Saunders, and B. F. Kennedy, “Handheld optical palpation of turbid tissue with motion-artifact correction,” Biomed. Opt. Express 10(1), 226–241 (2019).
[Crossref] [PubMed]

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

Kennedy, K. M.

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

Khouchani, M.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Kirk, R. W.

Kling, S.

Koh, S. H.

Kotynek, J. G.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Krajancich, B.

Krekel, N. M. A.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Kruczak, A.

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Lamouche, G.

Larin, K. V.

Laroia, A.

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Latham, B.

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Lawrence, G.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Li, J.

Li, L.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Li, Q.

Liau, J.

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Liu, C. H.

Lopes Cardozo, A. M. F.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Machiavello, J. C.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Maestro, C.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Majid, A. S.

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

Marcos, S.

Marcy, M.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Mariappan, Y. K.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

McLaughlin, R. A.

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

Meijer, S.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Mitus, J. W.

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Muller, S.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Mulligan, J. A.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Munro, P. R. T.

Nair, A.

Nguyen, F. T.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Oliphant, U. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Park, J. M.

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Pazos, V.

Pereira, J.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Quaranta, D.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Rais, H.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Ramier, A.

Raoust, I.

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

Ronald, M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Rowland, K. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Rys, J.

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Salvador, X.

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

Sampson, D. D.

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

Sarunic, M. V.

Sas-Korczynska, B.

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Saunders, C. M.

B. Krajancich, A. Curatolo, Q. Fang, R. Zilkens, B. F. Dessauvagie, C. M. Saunders, and B. F. Kennedy, “Handheld optical palpation of turbid tissue with motion-artifact correction,” Biomed. Opt. Express 10(1), 226–241 (2019).
[Crossref] [PubMed]

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Scarcelli, G.

Schill, A.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Shaalan, M. A.

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

Sharma, N. R.

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

Sheppard, C.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Sigrist, R. M. S.

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

Singh, M.

Soumani, A.

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Tan, W.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Taylor, D. B.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Tien, A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Trivella, M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Untracht, G. R.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

van den Tol, M. P.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

van der Meulen, J. H. P.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

van der Veen, H.

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Wang, J.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Wang, S.

Watts, L.

Wijesinghe, P.

M. S. Hepburn, P. Wijesinghe, L. Chin, and B. F. Kennedy, “Analysis of spatial resolution in phase-sensitive compression optical coherence elastography,” Biomed. Opt. Express 10(3), 1496–1513 (2019).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Willmann, J. K.

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

Wu, C.

Yang, L.

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Yang, X.

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

Yun, S. H.

Zilkens, R.

Zysk, A. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

ANZ J. Surg. (1)

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Arch. Med. Sci. (1)

J. W. Mituś, B. Sas-Korczyńska, A. Kruczak, M. Jasiówka, and J. Ryś, “Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature,” Arch. Med. Sci. 12(6), 1384–1388 (2016).
[Crossref] [PubMed]

Biomed. Opt. Express (12)

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref] [PubMed]

W. M. Allen, K. M. Kennedy, Q. Fang, L. Chin, A. Curatolo, L. Watts, R. Zilkens, S. L. Chin, B. F. Dessauvagie, B. Latham, C. M. Saunders, and B. F. Kennedy, “Wide-field quantitative micro-elastography of human breast tissue,” Biomed. Opt. Express 9(3), 1082–1096 (2018).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

S. Es’haghian, K. M. Kennedy, P. Gong, Q. Li, L. Chin, P. Wijesinghe, D. D. Sampson, R. A. McLaughlin, and B. F. Kennedy, “In vivo volumetric quantitative micro-elastography of human skin,” Biomed. Opt. Express 8(5), 2458–2471 (2017).
[Crossref] [PubMed]

S. Wang and K. V. Larin, “Noncontact depth-resolved micro-scale optical coherence elastography of the cornea,” Biomed. Opt. Express 5(11), 3807–3821 (2014).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

M. J. Ju, M. Heisler, A. Athwal, M. V. Sarunic, and Y. Jian, “Effective bidirectional scanning pattern for optical coherence tomography angiography,” Biomed. Opt. Express 9(5), 2336–2350 (2018).
[Crossref] [PubMed]

M. S. Hepburn, P. Wijesinghe, L. Chin, and B. F. Kennedy, “Analysis of spatial resolution in phase-sensitive compression optical coherence elastography,” Biomed. Opt. Express 10(3), 1496–1513 (2019).
[Crossref] [PubMed]

B. I. Akca, E. W. Chang, S. Kling, A. Ramier, G. Scarcelli, S. Marcos, and S. H. Yun, “Observation of sound-induced corneal vibrational modes by optical coherence tomography,” Biomed. Opt. Express 6(9), 3313–3319 (2015).
[Crossref] [PubMed]

B. Krajancich, A. Curatolo, Q. Fang, R. Zilkens, B. F. Dessauvagie, C. M. Saunders, and B. F. Kennedy, “Handheld optical palpation of turbid tissue with motion-artifact correction,” Biomed. Opt. Express 10(1), 226–241 (2019).
[Crossref] [PubMed]

BMJ (1)

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. P. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Can. Assoc. Radiol. J. (1)

J. M. Park, L. Yang, A. Laroia, E. A. Franken, and L. L. Fajardo, “Missed and/or misinterpreted lesions in breast ultrasound: reasons and solutions,” Can. Assoc. Radiol. J. 62(1), 41–49 (2011).
[Crossref] [PubMed]

Cancer Res. (2)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Clin. Anat. (1)

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

Eur. J. Surg. Oncol. (1)

T. Ihrai, D. Quaranta, Y. Fouche, J. C. Machiavello, I. Raoust, C. Chapellier, C. Maestro, M. Marcy, J. M. Ferrero, and B. Flipo, “Intraoperative radiological margin assessment in breast-conserving surgery,” Eur. J. Surg. Oncol. 40(4), 449–453 (2014).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (2)

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

J. Egypt. Natl. Canc. Inst. (1)

R. M. Kamal, N. M. Abdel Razek, M. A. G. Hassan, and M. A. Shaalan, “Missed breast carcinoma; why and how to avoid?” J. Egypt. Natl. Canc. Inst. 19(3), 178–194 (2007).
[PubMed]

J. Med. Case Reports (1)

H. Alaoui M’hamdi, F. Abbad, H. Rais, H. Asmouki, A. Soumani, M. Khouchani, and R. Belbaraka, “Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature,” J. Med. Case Reports 12(1), 43 (2018).
[Crossref] [PubMed]

J. R. Soc. Interface (1)

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

Lancet Oncol. (1)

N. M. A. Krekel, M. H. Haloua, A. M. F. Lopes Cardozo, R. H. de Wit, A. M. Bosch, L. M. de Widt-Levert, S. Muller, H. van der Veen, E. Bergers, E. S. M. de Lange de Klerk, S. Meijer, and M. P. van den Tol, “Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial,” Lancet Oncol. 14(1), 48–54 (2013).
[Crossref] [PubMed]

Nat. Photonics (1)

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Opt. Lett. (2)

Proc. Bayl. Univ. Med. Cent. (1)

K. Y. Ha, P. Deleon, and W. Deleon, “Invasive mucinous carcinoma of the breast,” Proc. Bayl. Univ. Med. Cent. 26(3), 295–297 (2013).
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Radiographics (1)

A. S. Majid, E. S. de Paredes, R. D. Doherty, N. R. Sharma, and X. Salvador, “Missed breast carcinoma: pitfalls and pearls,” Radiographics 23(4), 881–895 (2003).
[Crossref] [PubMed]

Sci. Rep. (2)

J. Wang, X. Yang, H. Cai, W. Tan, C. Jin, and L. Li, “Discrimination of breast cancer with microcalcifications on mammography by deep learning,” Sci. Rep. 6(1), 27327 (2016).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Theranostics (1)

R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, and J. K. Willmann, “Ultrasound elastography: review of techniques and clinical applications,” Theranostics 7(5), 1303–1329 (2017).
[Crossref] [PubMed]

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Figures (7)

Fig. 1
Fig. 1 Handheld QME probe. (a) Schematic of the experimental setup. SLD, superluminescent diode. FC, fiber coupler. PC, polarization coupler. BD, beam damper. MEMS, microelectromechanical system. BS, beam splitter. OL, objective lens. PA, PZT actuator. IW, imaging window. SB, silicone bi-layer. (b) Photograph of a handheld scan on excised breast tissue. (c) Schematic of the bi-layer used to map the surface stress on the sample.
Fig. 2
Fig. 2 Standard unidirectional and custom bidirectional scan patterns. (a), (b) and (c) represent the x-position, y-position and PZT stroke in the standard scan pattern. The green lines and red curves indicate the B-scans and the fly-back regions, respectively. (d), (e) and (f) represent the x-position, y-position and PZT stroke in the custom scan pattern. The green and blue lines indicate B-scans in the positive and negative x-directions, respectively. The red curves in (d) indicate the sinusoidal turn-around regions between B-scans.
Fig. 3
Fig. 3 Elasticity measurements performed on a homogeneous silicone phantom, using (a) the mounted setup with the custom scan pattern, (b) the handheld setup with the standard scan pattern and (c) the handheld setup with the custom scan pattern. The measured elasticity sensitivities are displayed in the insets of (a), (b) and (c).
Fig. 4
Fig. 4 En face OCT images and micro-elastograms acquired using, (a), (b) the mounted setup with the custom scan pattern, (c), (d) the handheld setup with the standard scan pattern, and (e), (f) the handheld setup with the custom scan pattern. The areas in red and blue dashed frames in (b), (d) and (f) are the selected to calculate the mean elasticity values and the standard deviations for the bulk material and the inclusion, respectively. Scale bars = 1 mm.
Fig. 5
Fig. 5 Co-registration of handheld scans and post-operative histology of a specimen containing IDC. (a) Photograph acquired using the handheld probe. (b) Photograph acquired using a wide-field bench-top setup. (c) Histology of the tissue sample. The green circles and red frames in (a), (b) and (c) indicate the CMOS camera FOV and the handheld QME scan area, respectively. The blue square frames in (a) and (b) indicate the same feature in both photographs. (d), (e) Zoomed-in photograph and histology image of the scan area. (f), (g) En face OCT image and micro-elastogram of the scanned tissue. An artifact caused by poor surface contact is marked by a white arrow in (f) and (g). IDC, invasive ductal carcinoma. S, stroma. Scale bars = 1 mm.
Fig. 6
Fig. 6 Handheld breast tissue results of a specimen containing IMC. (a) Photograph of the scanned area. (b) Co-registered histology. En face (c) OCT image and (d) micro-elastogram at a depth of 120 µm. IMC, invasive mucinous carcinoma. DCIS, ductal carcinoma in situ. Scale bars = 1 mm.
Fig. 7
Fig. 7 Handheld breast tissue results of a specimen containing IMSCC. (a) Photograph of the scanned area. (b) Co-registered histology. En face (c) OCT and (d) micro-elastogram at a depth of 120 µm from the tissue surface. IMSCC, invasive metaplastic spindle cell carcinoma. A, adipose. Scale bars = 1 mm.

Tables (1)

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Table 1 Measurement of the mean elasticity values and standard deviations

Metrics