Abstract

We investigate a spatial coordinate correction (SCC) method to track motion with high accuracy for optical coherence elastography (OCE). Through SCC, we refer the displacement field tracked by optical coherence tomography (OCT) in the loaded sample to individual material points defined in a fixed coordinate system. SCC allows OCE to perform spatially and temporally unambiguous tracking of displacement and enables accurate mechanical characterization of biological tissue for cancer diagnosis and tumor margin assessment. In this study, we validated the effectiveness of motion tracking based on SCC using experimental OCE data obtained from ex vivo human breast tissues.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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    [Crossref]
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    [Crossref]
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    [Crossref]
  31. X. Liu, F. Zaki, and Y. Wang, “Quantitative optical coherence elastography for robust stiffness assessment,” Appl. Sci. 8(8), 1255 (2018).
    [Crossref]
  32. A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
    [Crossref]
  33. K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
    [Crossref]
  34. T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
    [Crossref]
  35. L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
    [Crossref]

2019 (1)

2018 (4)

X. Liu, F. Zaki, and D. Renaud, “Assessment and removal of additive noise in a complex optical coherence tomography signal based on Doppler variation analysis,” Appl. Opt. 57(11), 2873–2880 (2018).
[Crossref]

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

X. Liu, F. Zaki, and Y. Wang, “Quantitative optical coherence elastography for robust stiffness assessment,” Appl. Sci. 8(8), 1255 (2018).
[Crossref]

2017 (2)

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography–OCT at work in tissue biomechanics,” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref]

2016 (6)

Y. Qiu, Y. Wang, Y. Xu, N. Chandra, J. Haorah, B. Hubbi, B. J. Pfister, and X. Liu, “Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties,” Biomed. Opt. Express 7(2), 688–700 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

Y. Qiu, F. R. Zaki, N. Chandra, S. A. Chester, and X. Liu, “Nonlinear characterization of elasticity using quantitative optical coherence elastography,” Biomed. Opt. Express 7(11), 4702–4710 (2016).
[Crossref]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

2015 (2)

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

2014 (2)

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 272–288 (2014).
[Crossref]

2012 (2)

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

2011 (1)

C. Sun, B. Standish, and V. X. D. Yang, “Optical coherence elastography: current status and future applications,” J. Biomed. Opt. 16(4), 043001 (2011).
[Crossref]

2010 (2)

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

2009 (1)

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

2007 (2)

A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
[Crossref]

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

2006 (1)

R. K. Wang, Z. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

2000 (2)

1998 (2)

J. Schmitt, “OCT elastography: imaging microscopic deformation and strain of tissue,” Opt. Express 3(6), 199–211 (1998).
[Crossref]

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

1995 (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

1991 (2)

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Aguirre, A. D.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Allen, W. M.

Baker, L.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Boppart, S. A.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Bouma, B.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Brauer, K.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Brezinski, M. E.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Cespedes, I.

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

Chandra, N.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Chen, Z.

Chester, S. A.

Chin, L.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

Cohen, D. W.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Connolly, J. L.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Curatolo, A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Danthu, V.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Dantuono, J. T.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Dargatz, M.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

de Boer, J. F.

De Stefano, V. S.

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

Dong, L.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Dupps Jr, W. J.

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

Evans, A.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Ferguson, R.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Ford, M. R.

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

Fujimoto, J. G.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Fung, Y.-C.

Y.-C. Fung, Mechanical properties of living tissues (Springer, 1993), Vol. 547.

Garra, B. S.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Gelikonov, G.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Gelikonov, G. V.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

Gelikonov, V. M.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

Gladkova, N. D.

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Gubarkova, E. V.

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

Hall, T.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Hammer, D.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Haorah, J.

Hee, M. R.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Hinds, M.

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Holz, D.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Hubbi, B.

Iftimia, N.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Jordan, L.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Jung, H. K.

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

Kallel, F.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Kennedy, B. F.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 272–288 (2014).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

Kennedy, K. M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 272–288 (2014).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

Kim, H.

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

Kim, S. J.

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

Kirk, R. W.

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Kirkpatrick, S.

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Kirkpatrick, S. J.

R. K. Wang, Z. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

Ko, K. H.

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

Koh, S. H.

Krouskop, T. A.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Kuznetsov, S. S.

Larin, K. V.

Latham, B.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

Lee, H.-C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Li, X.

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Liu, X.

Lorenser, D.

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Lorenzen, J.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

Lorenzen, M.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

Ma, Z.

R. K. Wang, Z. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

Matveev, L.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Matveev, L. A.

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

Matveyev, A.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Matveyev, A. L.

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

McLaughlin, R. A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

McLean, D.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Moiseev, A.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Mondelblatt, A. E.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Mujat, M.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Munro, P. R.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

Nelson, J. S.

Oberai, A. A.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Ophir, J.

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

Pavlova, N. P.

Pfister, B. J.

Plekhanov, A. A.

Plewes, D.

A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
[Crossref]

Ponnekanti, H.

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Purdie, C.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Qiu, Y.

Quirk, B. C.

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Renaud, D.

Robbins, P. D.

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Ronald, M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

Sadd, M. H.

M. H. Sadd, Elasticity: theory, applications, and numerics (Academic Press, 2009).

Samani, A.

A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
[Crossref]

Sampson, D. D.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography–OCT at work in tissue biomechanics,” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 272–288 (2014).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

Saunders, C. M.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Saxer, C.

Schmitt, J.

Schrader, D.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Scolaro, L.

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Seven, I.

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

Sinkus, R.

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

Sirotkina, M. A.

Southern, J. F.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Sovetsky, A.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Sovetsky, A. A.

Standish, B.

C. Sun, B. Standish, and V. X. D. Yang, “Optical coherence elastography: current status and future applications,” J. Biomed. Opt. 16(4), 043001 (2011).
[Crossref]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Sun, C.

C. Sun, B. Standish, and V. X. D. Yang, “Optical coherence elastography: current status and future applications,” J. Biomed. Opt. 16(4), 043001 (2011).
[Crossref]

Swanson, E. A.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Tearney, G. J.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Thompson, A.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Thomson, K.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Tien, A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

Tsai, T.-H.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Ustun, T.

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Vitkin, A.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

Vorontsov, A. Y.

Vorontsov, D. A.

Wang, R. K.

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

R. K. Wang, Z. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

Wang, Y.

X. Liu, F. Zaki, and Y. Wang, “Quantitative optical coherence elastography for robust stiffness assessment,” Appl. Sci. 8(8), 1255 (2018).
[Crossref]

Y. Qiu, Y. Wang, Y. Xu, N. Chandra, J. Haorah, B. Hubbi, B. J. Pfister, and X. Liu, “Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties,” Biomed. Opt. Express 7(2), 688–700 (2016).
[Crossref]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Wheeler, T. M.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Whelehan, P.

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Wijesinghe, P.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

Wood, B. A.

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

Xiang, S.

Xu, Y.

Yang, V. X. D.

C. Sun, B. Standish, and V. X. D. Yang, “Optical coherence elastography: current status and future applications,” J. Biomed. Opt. 16(4), 043001 (2011).
[Crossref]

Yazdi, Y.

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

Yoon, J. H.

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

Zagaynova, E. V.

Zaitsev, V.

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Zaitsev, V. Y.

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

Zaki, F.

Zaki, F. R.

Zhao, Y.

Zhou, C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Zubovits, J.

A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
[Crossref]

Appl. Opt. (1)

Appl. Phys. Lett. (2)

R. K. Wang, Z. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Appl. Sci. (1)

X. Liu, F. Zaki, and Y. Wang, “Quantitative optical coherence elastography for robust stiffness assessment,” Appl. Sci. 8(8), 1255 (2018).
[Crossref]

Biomed. Opt. Express (6)

E. V. Gubarkova, A. A. Sovetsky, V. Y. Zaitsev, A. L. Matveyev, D. A. Vorontsov, M. A. Sirotkina, L. A. Matveev, A. A. Plekhanov, N. P. Pavlova, S. S. Kuznetsov, A. Y. Vorontsov, E. V. Zagaynova, and N. D. Gladkova, “OCT-elastography-based optical biopsy for breast cancer delineation and express assessment of morphological/molecular subtypes,” Biomed. Opt. Express 10(5), 2244–2263 (2019).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref]

Y. Qiu, Y. Wang, Y. Xu, N. Chandra, J. Haorah, B. Hubbi, B. J. Pfister, and X. Liu, “Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties,” Biomed. Opt. Express 7(2), 688–700 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref]

Y. Qiu, F. R. Zaki, N. Chandra, S. A. Chester, and X. Liu, “Nonlinear characterization of elasticity using quantitative optical coherence elastography,” Biomed. Opt. Express 7(11), 4702–4710 (2016).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography–OCT at work in tissue biomechanics,” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref]

Breast Cancer Res. (1)

A. Evans, P. Whelehan, K. Thomson, D. McLean, K. Brauer, C. Purdie, L. Jordan, L. Baker, and A. Thompson, “Quantitative shear wave ultrasound elastography: initial experience in solid breast masses,” Breast Cancer Res. 12(6), R104 (2010).
[Crossref]

Cancer Res. (2)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref]

Eur Radiol (1)

K. H. Ko, H. K. Jung, S. J. Kim, H. Kim, and J. H. Yoon, “Potential role of shear-wave ultrasound elastography for the differential diagnosis of breast non-mass lesions: preliminary report,” Eur Radiol 24(2), 305–311 (2014).
[Crossref]

IEEE J. Sel. Top. Quantum Electron. (3)

R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, “Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1184–1191 (2012).
[Crossref]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 272–288 (2014).
[Crossref]

J. Biomed. Opt. (3)

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, V. M. Gelikonov, and A. Vitkin, “Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography,” J. Biomed. Opt. 20(7), 075006 (2015).
[Crossref]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[Crossref]

C. Sun, B. Standish, and V. X. D. Yang, “Optical coherence elastography: current status and future applications,” J. Biomed. Opt. 16(4), 043001 (2011).
[Crossref]

J. Biophotonics (2)

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref]

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref]

Laser Phys. Lett. (1)

A. Matveyev, L. Matveev, A. Sovetsky, G. Gelikonov, A. Moiseev, and V. Zaitsev, “Vector method for strain estimation in phase-sensitive optical coherence elastography,” Laser Phys. Lett. 15(6), 065603 (2018).
[Crossref]

Nat. Med. (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical biopsy and imaging using optical coherence tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref]

Opt. Express (1)

Opt. Lett. (1)

Phys. Med. Biol. (2)

A. Samani, J. Zubovits, and D. Plewes, “Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples,” Phys. Med. Biol. 52(6), 1565–1576 (2007).
[Crossref]

R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz, and D. Holz, “High-resolution tensor MR elastography for breast tumour detection,” Phys. Med. Biol. 45(6), 1649–1664 (2000).
[Crossref]

PLoS One (1)

V. S. De Stefano, M. R. Ford, I. Seven, and W. J. Dupps Jr, “Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography,” PLoS One 13(12), e0209480 (2018).
[Crossref]

Rev. Sci. Instrum. (1)

N. Iftimia, M. Mujat, T. Ustun, R. Ferguson, V. Danthu, and D. Hammer, “Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance,” Rev. Sci. Instrum. 80(2), 024302 (2009).
[Crossref]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref]

Ultrason. Imaging (2)

J. Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref]

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref]

Other (2)

Y.-C. Fung, Mechanical properties of living tissues (Springer, 1993), Vol. 547.

M. H. Sadd, Elasticity: theory, applications, and numerics (Academic Press, 2009).

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Figures (8)

Fig. 1.
Fig. 1. (a) In the undeformed sample, OCT pixel P at coordinate r0 acquires signal from material points within the green cube; (b) With motion field established, OCT pixel P at coordinate r0 acquires signal from a different set material points within the blue cube; (c) the measurement has cylindrical symmetry.
Fig. 2.
Fig. 2. (a) discrete OCT measurement taken at δt (green circles); (b) material points sampled by OCT pixels come from different spatial locations in the undeformed sample (red circles); (c) OCT measurement of velocity in the fixed coordinate system corresponds to non-uniform spatial sampling; (d) spatial resampling into a uniform grid.
Fig. 3.
Fig. 3. Flow chart to process all the OCT data acquired during the compression process to the undeformed coordinate.
Fig. 4.
Fig. 4. The configuration of the qOCE system used in this study. FC: fiber coupler; SLD: superluminescent diode; GRIN: gradient-index lens.
Fig. 5.
Fig. 5. Structural Ascans obtained using the qOCE probe before (black signal) and after (red signal) the compression process.
Fig. 6.
Fig. 6. For an optically and mechanically homogeneous phantom under compression in OCE measurement, displacement of material points at different depths (z = 0.48 mm, 0.84 mm, and 1.08 mm), obtained through SCC (solid) and directly from OCT data (dashed).
Fig. 7.
Fig. 7. (a) Structural Bscan of the tissue specimen (human breast adipose tissue) with scale bar representing 0.5 mm; (b) instantaneous velocity extracted with SCC during the compression process; (c) instantaneous velocity extracted without SCC during the compression process; (d) depth resolved displacement accumulated during the compression process with (black) and without (red) SCC; (e) Ascan (structural) obtained from the site where OCE measurement was performed; (f) cumulative displacement of material points originally located at 0.24 mm (blue) and 0.78 mm (red) over the compression process (solid curves), and cumulative displacement seen by OCT pixels at 0.24 mm (blue) and 0.78 mm (red) over the compression process (dashed curves).
Fig. 8.
Fig. 8. (a) Structural Bscan of the tissue specimen (tissue from stromal fibrosis breast lesion) with scale bar representing 0.5 mm; (b) instantaneous velocity extracted with SCC during the compression process; (c) instantaneous velocity extracted without SCC during the compression process; (d) depth resolved displacement accumulated during the compression process with (black) and without (red) SCC; (e) Ascan (structural) obtained from the site where OCE measurement was performed; (f) cumulative displacement of material points originally located at 0.24 mm (blue) and 0.78 mm (red) over the compression process (solid curves), and cumulative displacement seen by OCT pixels at 0.24 mm (blue) and 0.78 mm (red) over the compression process (dashed curves).

Tables (1)

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Table 1. Estimated values of stiffness for tissues from adipose and stromal fibrosis of the same patient.

Equations (8)

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v O C T ( z , t ) = λ 0 δ ϕ ( z , t ) 4 π δ t
l m ( δ t ) = m δ z + δ z δ t i = 1 m ε ˙ i ( δ t ) m δ z + δ z i = 1 m ε i ( δ t )
v [ l m ( δ t ) , δ t ] = v O C T ( m δ z , δ t )
v 0 ( z m , δ t ) = H { v [ l m ( δ t ) , δ t ] }
l m ( N δ t ) = m δ z [ 1 + δ t i = 1 m ε ˙ i ( δ t ) m ] [ 1 + δ t i = 1 m ε ˙ i ( 2 δ t ) m ] [ 1 + δ t i = 1 m ε ˙ i ( N δ t ) m ]
v [ l m ( N δ t ) , N δ t ] = v O C T ( m δ z , N δ t )
v 0 ( z m , N δ t ) = H { v [ l m ( N δ t ) , δ N t ] }
D ( z m ) = i = 1 N [ v 0 ( z m , i δ t ) δ t ]