Abstract

One of the advantages of photoacoustic imaging (PAI) is that its image contrast may come from exogenous agents. Such advantage leads to the development of a great number of exogenous probes. However, the biosafety of most of these contrast agents has not yet been confirmed, thus hindering their clinical translation. In this work, we report on the utilization of a clinically commonly used nutritional medicine, the Intralipid, as a new contrast agent for photoacoustic imaging. Intralipid consists of soybean oil, lecithin and glycerin and has long been adapted in clinical practices, mainly as a parenteral nutrition. In our study, we found that with Intralipid, the imaging sensitivity of PAI can be effectively enhanced, as demonstrated in in vivo imaging of different organs of nude mice. Further imaging studies on cancerous mice showed not only a twofold PA signal enhancement, but also a strong and long-lasting signal aggregation in the tumor region. Our result revealed the potential of Intralipid to be used in clinical PAI applications, since it is clinically safe, and can be easily prepared at very low cost.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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  25. P. Hai, J. Yao, K. I. Maslov, Y. Zhou, and L. V. Wang, “Near-infrared optical-resolution photoacoustic microscopy,” Opt. Lett. 39(17), 5192–5195 (2014).
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  26. J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
    [Crossref]
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    [Crossref]
  28. S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
    [Crossref]

2019 (1)

I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
[Crossref]

2018 (3)

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref]

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

2017 (2)

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
[Crossref]

2016 (1)

J. Weber, P. C. Beard, and S. E. Bohndiek, “Contrast agents for molecular photoacoustic imaging,” Nat. Methods 13(8), 639–650 (2016).
[Crossref]

2015 (2)

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
[Crossref]

2014 (3)

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
[Crossref]

S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
[Crossref]

P. Hai, J. Yao, K. I. Maslov, Y. Zhou, and L. V. Wang, “Near-infrared optical-resolution photoacoustic microscopy,” Opt. Lett. 39(17), 5192–5195 (2014).
[Crossref]

2013 (1)

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

2012 (1)

G. L. Weinberg, “Lipid Emulsion InfusionResuscitation for Local Anesthetic and Other Drug Overdose,” Anesthesiology 117(1), 180–187 (2012).
[Crossref]

2011 (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref]

2010 (3)

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[Crossref]

P. R. Ginimuge and S. D. Jyothi, “Methylene blue: revisited,” J. Anaesthesiol. Clin. Pharmacol. 26(4), 517–520 (2010).

L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
[Crossref]

2008 (1)

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

2006 (2)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref]

2005 (1)

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 71(1), 016706 (2005).
[Crossref]

1994 (1)

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref]

1992 (1)

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
[Crossref]

1976 (1)

L. M. Hansen, B. Hardie, and J. Hidalgo, “Fat emulsion for intravenous administration: clinical experience with intralipid 10%,” Ann. Surg. 184(1), 80–88 (1976).
[Crossref]

Andreou, C.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

Appleton, C. M.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref]

Bachmann, H. S.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref]

Beard, P. C.

J. Weber, P. C. Beard, and S. E. Bohndiek, “Contrast agents for molecular photoacoustic imaging,” Nat. Methods 13(8), 639–650 (2016).
[Crossref]

Bern, S.

L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
[Crossref]

Bodapati, S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Bohndiek, S. E.

J. Weber, P. C. Beard, and S. E. Bohndiek, “Contrast agents for molecular photoacoustic imaging,” Nat. Methods 13(8), 639–650 (2016).
[Crossref]

Burton, N. C.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

Chen, X.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Cheng, Z.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Choi, C.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

Claussen, J.

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

Dai, H.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Dai, Z.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

De la Zerda, A.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Dean-Ben, X. L.

I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
[Crossref]

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
[Crossref]

Deliolanis, N.

S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
[Crossref]

Deng, Z.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

Diana, M.

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

Dijkstra, J.

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

Donabedian, P.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

Du, C.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
[Crossref]

Egger, C.

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

Fischer, S.

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

Flock, S. T.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
[Crossref]

Gambhir, S. S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Ginimuge, P. R.

P. R. Ginimuge and S. D. Jyothi, “Methylene blue: revisited,” J. Anaesthesiol. Clin. Pharmacol. 26(4), 517–520 (2010).

Gottschalk, S.

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
[Crossref]

Gragoudas, E. S.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref]

Griewank, K.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

Grimm, J.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
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Handgraaf, H. J. M.

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
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F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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L. M. Hansen, B. Hardie, and J. Hidalgo, “Fat emulsion for intravenous administration: clinical experience with intralipid 10%,” Ann. Surg. 184(1), 80–88 (1976).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
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I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
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S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
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L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
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Li, Y.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
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L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
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A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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Ma, T. J.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
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H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
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Maslov, K. I.

Mc Larney, B.

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
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I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
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L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
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S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
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V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
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Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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Qu, E.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
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I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
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X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
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V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
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Reiner, T.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
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I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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Rothschild, L.

L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
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Sardella, T. C.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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Schadendorf, D.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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Schmedt, C. G.

I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
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Shi, J.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
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Shoham, S.

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
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Slakter, J. S.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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Smith, B. R.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
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J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
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M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
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Star, W. M.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
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Stoffels, I.

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
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Stoica, G.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
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Tang, J.

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

Tzoumas, S.

S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
[Crossref]

Urich, A.

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

Vahrmeijer, A. L.

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

Vaithilingam, S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

van Gemert, M. J.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
[Crossref]

van Manen, L.

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

Vetter, M.

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

Volkow, N. D.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
[Crossref]

Wang, J.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

Wang, L. V.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref]

J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
[Crossref]

P. Hai, J. Yao, K. I. Maslov, Y. Zhou, and L. V. Wang, “Near-infrared optical-resolution photoacoustic microscopy,” Opt. Lett. 39(17), 5192–5195 (2014).
[Crossref]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 71(1), 016706 (2005).
[Crossref]

Wang, S.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

Weber, J.

J. Weber, P. C. Beard, and S. E. Bohndiek, “Contrast agents for molecular photoacoustic imaging,” Nat. Methods 13(8), 639–650 (2016).
[Crossref]

Weinberg, G.

L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
[Crossref]

Weinberg, G. L.

G. L. Weinberg, “Lipid Emulsion InfusionResuscitation for Local Anesthetic and Other Drug Overdose,” Anesthesiology 117(1), 180–187 (2012).
[Crossref]

Wilson, B. C.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
[Crossref]

Xu, M.

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 71(1), 016706 (2005).
[Crossref]

Yannuzzi, L. A.

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref]

Yao, J.

J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
[Crossref]

P. Hai, J. Yao, K. I. Maslov, Y. Zhou, and L. V. Wang, “Near-infrared optical-resolution photoacoustic microscopy,” Opt. Lett. 39(17), 5192–5195 (2014).
[Crossref]

You, J.

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
[Crossref]

Zavaleta, C.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

Zha, Z.

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

Zhang, H. F.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref]

Zhang, R.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref]

Zhou, Y.

Anesthesiology (1)

G. L. Weinberg, “Lipid Emulsion InfusionResuscitation for Local Anesthetic and Other Drug Overdose,” Anesthesiology 117(1), 180–187 (2012).
[Crossref]

Ann. Surg. (1)

L. M. Hansen, B. Hardie, and J. Hidalgo, “Fat emulsion for intravenous administration: clinical experience with intralipid 10%,” Ann. Surg. 184(1), 80–88 (1976).
[Crossref]

Chem. Rev. (1)

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[Crossref]

Chem. Sci. (1)

S. Roberts, C. Andreou, C. Choi, P. Donabedian, M. Jayaraman, E. C. Pratt, J. Tang, C. Perez-Medina, M. Jason de la Cruz, W. J. M. Mulder, J. Grimm, M. Kircher, and T. Reiner, “Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer,” Chem. Sci. 9(25), 5646–5657 (2018).
[Crossref]

Chem. Soc. Rev. (1)

X. L. Dean-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, and D. Razansky, “Advanced optoacoustic methods for multiscale imaging of in vivo dynamics,” Chem. Soc. Rev. 46(8), 2158–2198 (2017).
[Crossref]

IEEE Pulse (1)

J. Yao, L. Song, and L. V. Wang, “Photoacoustic microscopy: superdepth, superresolution, and superb contrast,” IEEE Pulse 6(3), 34–37 (2015).
[Crossref]

IEEE Trans. Med. Imaging (1)

S. Tzoumas, N. Deliolanis, S. Morscher, and V. Ntziachristos, “Unmixing Molecular Agents From Absorbing Tissue in Multispectral Optoacoustic Tomography,” IEEE Trans. Med. Imaging 33(1), 48–60 (2014).
[Crossref]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref]

J. Anaesthesiol. Clin. Pharmacol. (1)

P. R. Ginimuge and S. D. Jyothi, “Methylene blue: revisited,” J. Anaesthesiol. Clin. Pharmacol. 26(4), 517–520 (2010).

J. Surg. Oncol. (1)

L. van Manen, H. J. M. Handgraaf, M. Diana, J. Dijkstra, T. Ishizawa, A. L. Vahrmeijer, and J. S. D. Mieog, “A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery,” J. Surg. Oncol. 118(2), 283–300 (2018).
[Crossref]

Lasers Surg. Med. (1)

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992).
[Crossref]

N. Engl. J. Med. (1)

F. Knieling, C. Neufert, A. Hartmann, J. Claussen, A. Urich, C. Egger, M. Vetter, S. Fischer, L. Pfeifer, and A. Hagel, “Multispectral optoacoustic tomography for assessment of Crohn’s disease activity,” N. Engl. J. Med. 376(13), 1292–1294 (2017).
[Crossref]

Nanoscale (1)

Z. Zha, Z. Deng, Y. Li, C. Li, J. Wang, S. Wang, E. Qu, and Z. Dai, “Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging,” Nanoscale 5(10), 4462–4467 (2013).
[Crossref]

Nat. Biotechnol. (1)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref]

Nat. Commun. (1)

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref]

Nat. Methods (1)

J. Weber, P. C. Beard, and S. E. Bohndiek, “Contrast agents for molecular photoacoustic imaging,” Nat. Methods 13(8), 639–650 (2016).
[Crossref]

Nat. Nanotechnol. (1)

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref]

NeuroImage (1)

Y. Pan, J. You, N. D. Volkow, K. Park, and C. Du, “Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo,” NeuroImage 103, 492–501 (2014).
[Crossref]

Ophthalmology (1)

M. Hope-Ross, L. A. Yannuzzi, E. S. Gragoudas, D. R. Guyer, J. S. Slakter, J. A. Sorenson, S. Krupsky, D. A. Orlock, and C. A. Puliafito, “Adverse reactions due to indocyanine green,” Ophthalmology 101(3), 529–533 (1994).
[Crossref]

Opt. Lett. (1)

Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. (1)

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 71(1), 016706 (2005).
[Crossref]

Radiology (1)

I. Ivankovic, E. Mercep, C. G. Schmedt, X. L. Dean-Ben, and D. Razansky, “Real-time Volumetric Assessment of the Human Carotid Artery: Handheld Multispectral Optoacoustic Tomography,” Radiology 291(1), 45–50 (2019).
[Crossref]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Scand. J. Trauma Resusc. Emerg. Med. (1)

L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scand. J. Trauma Resusc. Emerg. Med. 18(1), 51 (2010).
[Crossref]

Sci. Transl. Med. (1)

I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Leyh, N. C. Burton, T. C. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, and J. Klode, “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,” Sci. Transl. Med. 7(317), 317ra199 (2015).
[Crossref]

Other (3)

“ https://www.drugs.com/pro/intralipid.html ”.

L. I. o. America, “American National Standard for Safe Use of Lasers,” Laser Institute of America (2007).

“ https://www.drugs.com/international/indocyanine-green.html .”

Supplementary Material (3)

NameDescription
» Visualization 1       Head; PAT; Intralipid; Before and after injection;
» Visualization 2       Abdomen; PAT; Intralipid; Before and after injection;
» Visualization 3       4T1 Tumor; PAT; Intralipid; Before and after injection;

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Figures (8)

Fig. 1.
Fig. 1. Schematic of the PAT system.
Fig. 2.
Fig. 2. (a) The PA intensity of physiological saline solution, 10% Intralipid and 20% Intralipid at different wavelengths, as measured by the described PAT imaging system. (b) The absorption spectra of saline solution, 10% Intralipid and 20% Intralipid.
Fig. 3.
Fig. 3. PAT images of the head and abdomen of healthy nude mice, before and after injection of 20% Intralipid. Arrows 1: jugular vein, 2: posterior ear vein, 3: the sagittal sinus, 4: the brain boundary, 5: renal cortex, 6: renal medulla, 7: intestine, and 8: subcutaneous blood vessels. Illumination wavelength: 760 nm. See online supporting information, Head Visualization 1 and Abdomen Visualization 2.
Fig. 4.
Fig. 4. Head PA intensity curve with saline solution, 10% Intralipid and 20% Intralipid. Time dependent PA intensity values were averaged from signals within the head area.
Fig. 5.
Fig. 5. PAT images of nude mouse bearing 4T1 tumor. (d) shows the PA intensity curves at tumor region and normal tissue. Time dependent PA intensity values were calculated as the mean intensity within normal tissue and tumor regions. Illumination wavelength: 760 nm. See online supporting information, Tumor Visualization 3.
Fig. 6.
Fig. 6. Statistical analysis of (a) head, (b) abdomen from all 6 healthy nude mice. Serial numbers 01 and 02 indicates two mice injected with the same solution.
Fig. 7.
Fig. 7. Statistical analysis of (a) Sagittal sinus, (d) Kidney from healthy nude mice and (b) Tumor, (c) Normal tissue from 2 cancerous mice. Serial numbers 01 and 02 indicates two different mice injected with the same solution (20% Intralipid).
Fig. 8.
Fig. 8. Statistical analysis of (a) Head, (b) Abdomen and (c) Liver from two healthy animal before and after injection of 50 ug/ml ICG. Serial numbers 01 and 02 indicates two mice injected with 50 ug/ml ICG.

Tables (1)

Tables Icon

Table 1. PA signal intensity of different materials (a. u.)

Metrics