Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 62,
  • Issue 2,
  • pp. 251-257
  • (2008)

Quantitative Nondestructive Methods for the Determination of Ticlopidine in Tablets Using Reflectance Near-Infrared and Fourier Transform Raman Spectroscopy

Not Accessible

Your library or personal account may give you access

Abstract

Two different nondestructive spectroscopy methods based on near-infrared (NIR) and Fourier transform (FT) Raman spectroscopy were developed for the determination of ticlopidine-hydrochloride (TCL) in pharmaceutical formulations and the results were compared to those obtained by high-performance liquid chromatography (HPLC). An NIR assay was performed by reflectance over the 850–1700 nm region using a partial least squares (PLS) prediction model, while the absolute FT-Raman intensity of TCL's most intense vibration was used for constructing the calibration curve. For both methodologies the spectra were obtained from the as-received film-coated tablets of TCL. The two quantitative techniques were built using five "manual compressed" tablets containing different concentrations and validated by evaluating the calibration model as well as the accuracy and precision. The models were applied to commercial preparations (Ticlid<sup>®</sup>). The results were compared to those obtained from the application of HPLC using the methodology described by "Sanofi Research Department" and were found to be in excellent agreement, proving that NIR, using fiber-optic probes, and FT-Raman spectroscopy can be used for the fast and reliable determination of the major component in pharmaceutical analysis.

PDF Article
More Like This
Optical system for tablet variety discrimination using visible/near-infrared spectroscopy

Yongni Shao, Yong He, and Xingyue Hu
Appl. Opt. 46(34) 8379-8384 (2007)

Nondestructive determination of SSC in an apple by using a portable near-infrared spectroscopy system

Yizhe Zhang, Jipeng Huang, Qiulei Zhang, Jinwei Liu, Yanli Meng, and Yan Yu
Appl. Opt. 61(12) 3419-3428 (2022)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved