Abstract

Raman spectroscopy has been implemented as an extremely powerful tool for the vibrational analysis of solid-phase synthesis. In this report, the application of both on-line and batch-mode Raman analysis is presented for the comprehensive characterization of a multi-step small-molecule synthesis. Throughout this application, near-infrared Raman spectroscopy also provides unprecedented utility for on-bead qualitative and quantitative investigations. Finally, the on-line experimental procedure presents the first opportunity for open-loop feedback control of solid-phase synthetic parameters through the real-time presentation of reaction progression using Raman spectroscopy.

Quantification of solid-phase chemical reactions using the temperature-dependent terahertz pulsed spectroscopy, sum rule, and Arrhenius theory: thermal decomposition of α-lactose monohydrate

G. A. Komandin, K. I. Zaytsev, I. N. Dolganova, V. S. Nozdrin, S. V. Chuchupal, V. B. Anzin, and I. E. Spektor
Opt. Express 30(6) 9208-9221 (2022)

Controlled synthesis of hollow Ag@Au nano-urchins with unique synergistic effects for ultrasensitive surface-enhanced Raman spectroscopy

Hua Zhang, Linlin Xu, Yue Tian, Ming Chen, Xiangdong Liu, and Feng Chen
Opt. Express 25(23) 29389-29400 (2017)

Raman spectroscopy: techniques and applications in the life sciences

Dustin W. Shipp, Faris Sinjab, and Ioan Notingher
Adv. Opt. Photon. 9(2) 315-428 (2017)

Characterization of elastomeric scaffolds developed for tissue engineering applications by compression and nanoindentation tests, μ-Raman and μ-Brillouin spectroscopies

Géraldine Rohman, Salah Ramtani, Sylvie Changotade, Credson Langueh, Didier Lutomski, Yves Roussigné, Florent Tétard, Fréderic Caupin, and Philippe Djemia
Biomed. Opt. Express 10(4) 1649-1659 (2019)

Use of Raman spectroscopy to screen diabetes mellitus with machine learning tools

Edgar Guevara, Juan Carlos Torres-Galván, Miguel G. Ramírez-Elías, Claudia Luevano-Contreras, and Francisco Javier González
Biomed. Opt. Express 9(10) 4998-5010 (2018)