Abstract

We have demonstrated the use of surface-enhanced Raman scattering (SERS) spectroscopy for the detection of the phenylalkylamines amphetamine and methamphetamine. This work can be viewed as the first phase of development toward a one-step drug detection method with a selective reactive coating on a SERS substrate. This work involves a fairly complicated coupling reaction prior to surface derivatization. Future efforts will be directed at creating a reactive coating directly on the surface. The amines were derivatized by a coupling reaction with 2-mercaptonicotinic acid (2-MNA) with the use of dicyclohexylcarbodiimide (DCC) as the coupling reagent to form the amide compounds AMNA [N-(1-methyl-2-phenylethyl)2-mercaptopyridine-3-carboxamide] and MMNA [N-methyl-N-(1-methyl-2-phenylethyl)-2-mercaptopyridine-3-carboxamide]. The amides were qualitatively identified from SERS spectra. Quantification of the amides was accomplished by adding the internal standard pentachlorothiophenol (PCTP) and measuring the intensity of Raman bands of the analyte relative to a Raman band of the internal standard. Calibration curves were plotted of the relative peak intensity ratios as a function of analyte concentration. Detection limits of 19 ppm and 17 ppm were found for amphetamine/2-MNA (AMNA) amide and methamphetamine/2-MNA (MMNA) amide, respectively.

PDF Article

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription