Abstract
A method is described that utilizes β-cyclodextrin and silica gel as shift reagents to distinguish between enantiomers by means of near-infrared transmission spectroscopy. The premise is that the spectrum of the (+)-enantiomer bound to the shift reagent will be different from that of the (−)-enantiomer bound to the same reagent. With the use of principal component analysis, the difference between the enantiomers can be distinguished. The resulting method is fast, simple, and of potential application in pharmaceutical process control.
PDF Article
More Like This
Cited By
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Login to access Optica Member Subscription