Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 48,
  • Issue 2,
  • pp. 190-193
  • (1994)

Identification of Breast Carcinomatous Tissue by Near-Infrared Reflectance Spectroscopy

Not Accessible

Your library or personal account may give you access

Abstract

NIR reflectance spectra of 110 cryostat sections of carcinomatous tissue and 114 cryostat sections of normal surrounding fibro-glandular tissue from 10 cases of breast cancer, identified by a classical pathology method, were scanned between 1100 and 2500 nm by a grating spectrometer in reflectance mode. Four wavelength intervals (1208-1242, 1746-1788, 2012-2048 and 2326-2368 nm) were found to be different for normal and carcinomatous tissues. In each interval, the second-derivative spectra of normal tissue showed a similar pattern with several characteristic peaks. In order to test the capacity of NIR spectroscopy in discriminating between normal and carcinomatous breast samples, 104 tissue sections from five additional cases were scanned prior to microscopic examination. The diagnostic prediction of NIR spectroscopy coincided exactly with the histology diagnosis for all the samples. Moreover, the presence of even a minute quantity of cancer infiltration can be detected by NIR spectroscopy, in total accordance with the microscopical observation. Therefore, the results of our experiments allow us to consider that NIR spectroscopy might become, with feasible improvements, an accurate, rapid, and reliable method for detecting breast cancer.

PDF Article
More Like This
LIF spectroscopy of stained malignant breast tissues

Fatemeh Ghasemi, Parviz Parvin, Najme Sadat Hosseini Motlagh, and Shahriar Abachi
Biomed. Opt. Express 8(2) 512-523 (2017)

Concentration analysis of breast tissue phantoms with terahertz spectroscopy

Bao C. Q. Truong, Anthony J. Fitzgerald, Shuting Fan, and Vincent P. Wallace
Biomed. Opt. Express 9(3) 1334-1349 (2018)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved