Abstract

A typical pharmaceutical tablet is too small for analysis in an ordinary NIRA instrument. An intact tablet will not begin to fill a solid-sample holder designed for use with a powdered sample. Grinding the sample is likewise unproductive, as a single tablet also does not provide enough powder for the sample cup. Potential NIRA applications such as the detection of product tampering and even routine quality control are unnecessarily complicated by this grinding requirement. A method of analyzing single, intact tablets using a double-reflecting aluminum sample holder is described in this report. The integrity of the sample is preserved during the analysis, allowing the tablet to be sold or consumed after the procedure.

Optical system for tablet variety discrimination using visible/near-infrared spectroscopy

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A Reflecting Microscope for Infrared Spectrometry*

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Comprehensive study of solid pharmaceutical tablets in visible, near infrared (NIR), and longwave infrared (LWIR) spectral regions using a rapid simultaneous ultraviolet/visible/NIR (UVN) + LWIR laser-induced breakdown spectroscopy linear arrays detection system and a fast acousto-optic tunable filter NIR spectrometer

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Opt. Express 25(22) 26885-26897 (2017)

Spectrographic Analysis of Briquetted Tablets*

Harry W. Dietert
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Sulfur as a proposed near infrared reflectance standard

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