A new type of sample holder suitable for Raman difference spectroscopy is described. It can accommodate up to six different samples (~10 μL) contained in capillary cells such as those commonly used in conventional Raman spectroscopy. This system can be readily incorporated in an instrument equipped with a conventional computerized control system and it provides a differential frequency accuracy (±0.03 cm<sup>−1</sup>) which is comparable to that of other existing devices.

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