The change in the plane of polarization of light can be an important experimental parameter in many spectroscopic determinations, as in, for example, polarization spectroscopy and the Raman-induced Kerr effect. Also, polarimetric detection, in conjunction with high-performance liquid chromatography (HPLC), has been used to investigate sugars in urine, cholesterol in blood, and the chiral components of fossil fuels. Recent work has demonstrated the utility of converting the very selective polarimetric detector to a universal one. Additionally, the same system can be used to simultaneously detect analyte absorptions with excellent sensitivity.

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