Abstract

In this work, we report the application of Raman microspectroscopy for analysis of the refractive index of a range of tissue phantoms. Using both a custom-developed setup with visible laser source and a commercial microspectrometer with near infrared laser, we measured the Raman spectra of gelatin hydrogels at various concentrations. By building a calibration curve from measured refractometry data and Raman scattering intensity for different vibrational modes of the hydrogel, we were able to predict the refractive indices of the gels from their Raman spectra. This work highlights the importance of a correlative approach through Brillouin–Raman microspectroscopy for the mechano–chemical analysis of biologically relevant samples.

© 2021 The Author(s)

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  1. M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.
  2. F. Palombo, D. Fioretto. “Brillouin Light Scattering: Applications in Biomedical Sciences”. Chem. Rev. 2019. 119(13): 7833–7847.
  3. R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.
  4. L. Brillouin. Diffusion de la Lumière et des Rayons X par un Corps Transparent Homogène-Influence de L'agitation Thermique”. AnPh. 1922. 9(17): 88–122.
  5. M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.
  6. S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.
  7. G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.
  8. J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.
  9. R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.
  10. I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.
  11. S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.
  12. T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.
  13. G. Scarcelli, S.H. Yun. In Vivo Brillouin Optical Microscopy of the Human Eye”. Opt. Express. 2012. 20(8): 9197–9202.
  14. F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.
  15. F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.
  16. S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.
  17. F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.
  18. M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.
  19. G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.
  20. K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.
  21. M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.
  22. K. Kim, J. Guck. The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust Against Strong Perturbation”. Biophys. J. 2020. 119(10): 1946–1957.
  23. S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.
  24. F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.
  25. A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.
  26. M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.
  27. N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.
  28. P.H. Eilers, H.F. Boelens. Baseline Correction with Asymmetric Least Squares Smoothing”. Leiden University Medical Centre Report. 2005. 1(1): 5.
  29. B.G. Frushour, J.L. Koenig. Raman Scattering of Collagen, Gelatin, and Elastin”. Biopolymers: Original Research on Biomolecules. 1975. 14(2): 379–391.
  30. J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.
  31. J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.
  32. Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.
  33. L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.
  34. E. Li-Chan. The Applications of Raman Spectroscopy in Food Science”. Trends Food Sci. Tech. 1996. 11(7): 361–370.
  35. A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.
  36. P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.
  37. D.M. Carey, G.M. Korenowski. Measurement of the Raman Spectrum of Liquid Water”. J. Chem. Phys. 1998. 108(7): 2669–2675.2328.
  38. S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

2020 (9)

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.

S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

K. Kim, J. Guck. The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust Against Strong Perturbation”. Biophys. J. 2020. 119(10): 1946–1957.

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

2019 (5)

N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.

A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

F. Palombo, D. Fioretto. “Brillouin Light Scattering: Applications in Biomedical Sciences”. Chem. Rev. 2019. 119(13): 7833–7847.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

2018 (6)

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

2017 (3)

M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

2016 (1)

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

2014 (2)

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

2012 (2)

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

G. Scarcelli, S.H. Yun. In Vivo Brillouin Optical Microscopy of the Human Eye”. Opt. Express. 2012. 20(8): 9197–9202.

2011 (1)

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

2007 (1)

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

2005 (1)

P.H. Eilers, H.F. Boelens. Baseline Correction with Asymmetric Least Squares Smoothing”. Leiden University Medical Centre Report. 2005. 1(1): 5.

1998 (1)

D.M. Carey, G.M. Korenowski. Measurement of the Raman Spectrum of Liquid Water”. J. Chem. Phys. 1998. 108(7): 2669–2675.2328.

1997 (1)

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

1996 (1)

E. Li-Chan. The Applications of Raman Spectroscopy in Food Science”. Trends Food Sci. Tech. 1996. 11(7): 361–370.

1990 (1)

S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.

1975 (1)

B.G. Frushour, J.L. Koenig. Raman Scattering of Collagen, Gelatin, and Elastin”. Biopolymers: Original Research on Biomolecules. 1975. 14(2): 379–391.

1937 (1)

P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.

1922 (1)

L. Brillouin. Diffusion de la Lumière et des Rayons X par un Corps Transparent Homogène-Influence de L'agitation Thermique”. AnPh. 1922. 9(17): 88–122.

Abuhattum, S.

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

Aliaga, A.E.

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

Alunni-Cardinali, M.

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

Andrew Chan, K.

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

Antonacci, G.

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

Astruc, T.

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

Bailey, M.

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.

Beck, T.

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

Ben-Zvi, A.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

Bevilacqua, C.

A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.

Bilenca, A.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

Boelens, H.F.

P.H. Eilers, H.F. Boelens. Baseline Correction with Asymmetric Least Squares Smoothing”. Leiden University Medical Centre Report. 2005. 1(1): 5.

Brañes, M.R.

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

Brasselet, S.

Brillouin, L.

L. Brillouin. Diffusion de la Lumière et des Rayons X par un Corps Transparent Homogène-Influence de L'agitation Thermique”. AnPh. 1922. 9(17): 88–122.

Burnham, J.

P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.

Campos-Vallette, M.M.

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

Caponi, S.

M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.

S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

Cárcamo, J.J.

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

Carey, D.M.

D.M. Carey, G.M. Korenowski. Measurement of the Raman Spectrum of Liquid Water”. J. Chem. Phys. 1998. 108(7): 2669–2675.2328.

Clavijo, R.E.

J.J. Cárcamo, A.E. Aliaga, R.E. Clavijo, M.R. Brañes, M.M. Campos-Vallette. Raman Study of the Shockwave Effect on Collagens”. Spectrochim. Acta, Part A. 2012. 86: 360–365.

Cojoc, G.

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

Corezzi, S.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

Correa, N.

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.

Cross, P.C.

P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.

Czarske, J.

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

Czibula, C.

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

Dagany, X.

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

De Gelder, J.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

De Gussem, K.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

de Turris, V.

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

Delanoë-Ayari, H.

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

Diz-Muñoz, A.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

Duconseille, A.

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

Edginton, R.S.

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

Eilers, P.H.

P.H. Eilers, H.F. Boelens. Baseline Correction with Asymmetric Least Squares Smoothing”. Leiden University Medical Centre Report. 2005. 1(1): 5.

Elsayad, K.

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

Fiore, A.

A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.

Fioretto, D.

S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.

F. Palombo, D. Fioretto. “Brillouin Light Scattering: Applications in Biomedical Sciences”. Chem. Rev. 2019. 119(13): 7833–7847.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

Frushour, B.G.

B.G. Frushour, J.L. Koenig. Raman Scattering of Collagen, Gelatin, and Elastin”. Biopolymers: Original Research on Biomolecules. 1975. 14(2): 379–391.

Gaillard, C.

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

Gillece, T.

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

Girardo, S.

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

Green, E.

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

Guck, J.

K. Kim, J. Guck. The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust Against Strong Perturbation”. Biophys. J. 2020. 119(10): 1946–1957.

Harding, S.

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.

Herington, J.L.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

Kajimoto, S.

M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.

Kim, K.

K. Kim, J. Guck. The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust Against Strong Perturbation”. Biophys. J. 2020. 119(10): 1946–1957.

Koenig, J.L.

B.G. Frushour, J.L. Koenig. Raman Scattering of Collagen, Gelatin, and Elastin”. Biopolymers: Original Research on Biomolecules. 1975. 14(2): 379–391.

Korenowski, G.M.

D.M. Carey, G.M. Korenowski. Measurement of the Raman Spectrum of Liquid Water”. J. Chem. Phys. 1998. 108(7): 2669–2675.2328.

Lainovic, T.

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

Lees, S.

S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.

Leighton, P.A.

P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.

Leikin, S.

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

Li-Chan, E.

E. Li-Chan. The Applications of Raman Spectroscopy in Food Science”. Trends Food Sci. Tech. 1996. 11(7): 361–370.

Lindsay, S.

S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.

Madami, M.

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

Margueritat, J.

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

Martinet, Q.

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

Masson, L.E.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

Mattana, S.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

Mattarelli, M.

S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.

M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

Moens, L.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

Möllmert, S.

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

Monnier, S.

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

Nakabayashi, T.

M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.

Nallala, J.

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

O'Brien, C.M.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

Palombo, F.

N. Correa, S. Harding, M. Bailey, S. Brasselet, F. Palombo. Image Analysis Applied to Brillouin Images of Tissue-Mimicking Collagen Gelatins”. Biomed. Opt. Express. 2019. 10(3): 1329–1338.

F. Palombo, D. Fioretto. “Brillouin Light Scattering: Applications in Biomedical Sciences”. Chem. Rev. 2019. 119(13): 7833–7847.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

Parsegian, V.

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

Pence, I.J.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

Prevedel, R.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

Remer, I.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

Rosa, A.

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

Ruocco, G.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

Sagini, K.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

Santé-Lhoutellier, V.

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

Scarcelli, G.

A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.

G. Scarcelli, S.H. Yun. In Vivo Brillouin Optical Microscopy of the Human Eye”. Opt. Express. 2012. 20(8): 9197–9202.

Scarponi, F.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

Schlüssler, R.

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

Schürmann, M.

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

Shaashoua, R.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

Shemesh, N.

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

Stone, N.

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

Takeuchi, M.

M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.

Tamagnini, F.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

Tao, N.-J.

S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.

Teichert, C.

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

Ulbricht, E.

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

Urbanelli, L.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

Urstöger, G.

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

Vandenabeele, P.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

Vassalli, M.

M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.

Virgone-Carlotta, A.

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

Walrafen, G.

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

Winlove, C.P.

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

Yang, W.-H.

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

Yun, S.H.

Zhang, G.

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

Zhang, Q.

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

ACS Photonics (1)

M. Mattarelli, M. Vassalli, S. Caponi. Relevant Length Scales in Brillouin Imaging of Biomaterials: The Interplay Between Phonons Propagation and Light Focalization”. ACS Photonics. 2020. 7(9): 2319–2328.

Acta Biomater (1)

T. Lainović, J. Margueritat, Q. Martinet, X. Dagany, et al. Micromechanical Imaging of Dentin with Brillouin Microscopy”. Acta Biomater. 2020. 105: 214–222.

Analyst (2)

F. Palombo, M. Madami, N. Stone, D. Fioretto. Mechanical Mapping with Chemical Specificity by Confocal Brillouin and Raman Microscopy”. Analyst. 2014. 139(4): 729–733.

L.E. Masson, C.M. O'Brien, I.J. Pence, J.L. Herington, et al. Dual Excitation Wavelength System for Combined Fingerprint and High Wavenumber Raman Spectroscopy”. Analyst. 2018. 143(24): 6049–6060.

AnPh (1)

L. Brillouin. Diffusion de la Lumière et des Rayons X par un Corps Transparent Homogène-Influence de L'agitation Thermique”. AnPh. 1922. 9(17): 88–122.

Biomed. Opt. Express (1)

Biophys. J (2)

K. Kim, J. Guck. The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust Against Strong Perturbation”. Biophys. J. 2020. 119(10): 1946–1957.

R. Schlüssler, S. Möllmert, S. Abuhattum, G. Cojoc, et al. Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging”. Biophys. J. 2018. 115(5): 911–923.

Biophys. Rev (1)

G. Antonacci, T. Beck, A. Bilenca, J. Czarske, et al. Recent Progress and Current Opinions in Brillouin Microscopy for Life Science Applications”. Biophys. Rev. 2020. 12(3): 615–624.

Biopolymers (1)

Q. Zhang, K. Andrew Chan, G. Zhang, T. Gillece, et al. Raman Microspectroscopic and Dynamic Vapor Sorption Characterization of Hydration in Collagen and Dermal Tissue”. Biopolymers. 2011. 95(9): 607–615.

Biopolymers: Original Research on Biomolecules (1)

B.G. Frushour, J.L. Koenig. Raman Scattering of Collagen, Gelatin, and Elastin”. Biopolymers: Original Research on Biomolecules. 1975. 14(2): 379–391.

Cellulose (1)

K. Elsayad, G. Urstöger, C. Czibula, C. Teichert, et al. Mechanical Properties of Cellulose Fibers Measured by Brillouin Spectroscopy”. Cellulose. 2020. 27: 4209–4220.

Chem. Rev (1)

F. Palombo, D. Fioretto. “Brillouin Light Scattering: Applications in Biomedical Sciences”. Chem. Rev. 2019. 119(13): 7833–7847.

Commun. Biol (1)

G. Antonacci, V. de Turris, A. Rosa, G. Ruocco. Background-Deflection Brillouin Microscopy Reveals Altered Biomechanics of Intracellular Stress Granules by ALS Protein FUS”. Commun. Biol. 2018. 1(1): 1–8.

Connect. Tissue Res (1)

S. Lees, N.-J. Tao, S. Lindsay. Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”. Connect. Tissue Res. 1990. 24(3–4): 187–205.

Data Brief (1)

M. Bailey, N. Correa, S. Harding, N. Stone, et al. Brillouin Microspectroscopy Data of Tissue-Mimicking Gelatin Hydrogels”. Data Brief. 2020. 29: 105267.

Food Hydrocoll (1)

A. Duconseille, C. Gaillard, V. Santé-Lhoutellier, T. Astruc. Molecular and Structural Changes in Gelatin Evidenced by Raman Microspectroscopy”. Food Hydrocoll. 2018. 77: 777–786.

J. Am. Chem. Soc (1)

P.C. Cross, J. Burnham, P.A. Leighton. The Raman Spectrum and the Structure of Water”. J. Am. Chem. Soc. 1937. 59(6): 1134–1147.

J. Biophotonics (2)

M. Schürmann, G. Cojoc, S. Girardo, E. Ulbricht, et al. Three-Dimensional Correlative Single. Cell Imaging Utilizing Fluorescence and Refractive Index Tomography. J. Biophotonics. 2018. 11(3): e201700145.

F. Palombo, M. Madami, D. Fioretto, J. Nallala, et al. Chemico-Mechanical Imaging of Barrett's Oesophagus”. J. Biophotonics. 2016. 9(7): 694–700.

J. Chem. Phys (1)

D.M. Carey, G.M. Korenowski. Measurement of the Raman Spectrum of Liquid Water”. J. Chem. Phys. 1998. 108(7): 2669–2675.2328.

J. Innov. Opt. Heal. Sci (1)

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, F. Palombo. Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain Studied by Brillouin Microspectroscopy and Correlative Raman Analysis”. J. Innov. Opt. Heal. Sci. 2017. 10(6): 1742001.

J. Phys. Chem. Lett (1)

M. Takeuchi, S. Kajimoto, T. Nakabayashi. Experimental Evaluation of the Density of Water in a Cell by Raman Microscopy”. J. Phys. Chem. Lett. 2017. 8(21): 5241–5245.

J. R. Soc. Interface (1)

F. Palombo, C.P. Winlove, R.S. Edginton, E. Green, et al. Biomechanics of Fibrous Proteins of the Extracellular Matrix Studied by Brillouin Scattering”. J. R. Soc. Interface. 2014. 11(101): 20140739.

J. Raman Spectrosc (1)

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens. Reference Database of Raman Spectra of Biological Molecules”. J. Raman Spectrosc. 2007. 38(9): 1133–1147.

Leiden University Medical Centre Report (1)

P.H. Eilers, H.F. Boelens. Baseline Correction with Asymmetric Least Squares Smoothing”. Leiden University Medical Centre Report. 2005. 1(1): 5.

Light-Sci. Appl (1)

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, et al. Non-Contact Mechanical and Chemical Analysis of Single Living Cells by Microspectroscopic Techniques”. Light-Sci. Appl. 2018. 7(2): 17139–17139.

Nat. Methods (2)

I. Remer, R. Shaashoua, N. Shemesh, A. Ben-Zvi, A. Bilenca. High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering Microscopy”. Nat. Methods. 2020. 17(9): 913–916.

R. Prevedel, A. Diz-Muñoz, G. Ruocco, G. Antonacci. “Brillouin Microscopy: An Emerging Tool for Mechanobiology”. Nat. Methods. 2019. 16(10): 969–977.

Opt. Express (1)

Opt. Lett (1)

S. Caponi, D. Fioretto, M. Mattarelli. On the Actual Spatial Resolution of Brillouin Imaging”. Opt. Lett. 2020. 45(5): 1063–1066.

Phys. Rev. Lett (2)

J. Margueritat, A. Virgone-Carlotta, S. Monnier, H. Delanoë-Ayari, et al. High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering”. Phys. Rev. Lett. 2019. 122(1): 018101.

A. Fiore, C. Bevilacqua, G. Scarcelli. Direct Three-Dimensional Measurement of Refractive Index via Dual Photon-Phonon Scattering”. Phys. Rev. Lett. 2019. 122(10): 103901.

Phys. Rev. X (1)

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, et al. High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy”. Phys. Rev. X. 2017. 7(3): 031015.

Proc. Natl. Acad. Sci. U.S.A (1)

S. Leikin, V. Parsegian, W.-H. Yang, G. Walrafen. Raman Spectral Evidence for Hydration Forces Between Collagen Triple Helices”. Proc. Natl. Acad. Sci. U.S.A. 1997. 94(21): 11312–11317.

Sci. Adv (1)

M. Bailey, M. Alunni-Cardinali, N. Correa, S. Caponi, et al. “Viscoelastic Properties of Biopolymer Hydrogels Determined by Brillouin Spectroscopy: A Probe of Tissue Micromechanics”. Sci. Adv. 2020. 6(44): eabc1937.

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