Abstract

A custom-designed optical configuration compatible with the use of micromachined multigroove internal reflection elements (μ-groove IREs) for attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy and imaging applications in microfluidic devices is described. The μ-groove IREs consist of several face-angled grooves etched into a single, monolithic silicon chip. The optical configuration permits individual grooves to be addressed by focusing synchrotron sourced IR light through a 150 µm pinhole aperture, restricting the beam spot size to a dimension smaller than that of the groove walls. The effective beam spot diameter at the ATR sampling plane is determined through deconvolution of the measured detector response and found to be 70 µm. The μ-groove IREs are highly compatible with standard photolithographic techniques as demonstrated by printing a 400 µm wide channel in an SU-8 film spin-coated on the IRE surface. Attenuated total reflection FT-IR mapping as a function of sample position across the channel illustrates the potential application of this approach for rapid prototyping of microfluidic devices.

© 2018 The Author(s)

Broadband near-field infrared spectromicroscopy using photothermal probes and synchrotron radiation

Paul M. Donaldson, Chris S Kelley, Mark D. Frogley, Jacob Filik, Katia Wehbe, and Gianfelice Cinque
Opt. Express 24(3) 1852-1864 (2016)

Chemical visualization of individual chondrocytes in articular cartilage by attenuated-total-reflection Fourier Transform Infrared Microimaging

Jianhua Yin and Yang Xia
Biomed. Opt. Express 2(4) 937-945 (2011)

Use of attenuated total reflectance Fourier transform infrared spectroscopy to monitor the development of lipid aggregate structures

Mateo R. Hernandez, Elyse N. Towns, Terry C. Ng, Brian C. Walsh, Richard Osibanjo, Atul N. Parikh, and Donald P. Land
Appl. Opt. 51(15) 2842-2846 (2012)

Supercontinuum-based Fourier transform infrared spectromicroscopy

F. Borondics, M. Jossent, C. Sandt, L. Lavoute, D. Gaponov, A. Hideur, P. Dumas, and S. Février
Optica 5(4) 378-381 (2018)

Near-field imaging and nano-Fourier-transform infrared spectroscopy using broadband synchrotron radiation

Peter Hermann, Arne Hoehl, Piotr Patoka, Florian Huth, Eckart Rühl, and Gerhard Ulm
Opt. Express 21(3) 2913-2919 (2013)