Abstract

Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve <i>r</i><sup>2</sup> > 0.98. Leave-one-out cross-validation demonstrates prediction errors of, <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

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