Abstract
There is a great need for cost-efficient non-invasive medical diagnostic tools for analyzing humanly exhaled air. Compared to present day methods, photoacoustic spectroscopy (PAS) can provide a compact and portable (bedside), sensitive and inexpensive solution. We demonstrate a novel portable photoacoustic spectroscopic platform for isotopic measurements of methane (${{\rm CH}_4}$). We identify and discriminate the ${^{12}{\rm CH}_4}$- and ${^{13}{\rm CH}_4}$ isotopologues and determine their mixing ratio. An Allan deviation analysis shows that the noise equivalent concentration for ${\rm CH}_4$ is 200 ppt (pmol/mol) at 100 s of integration time, corresponding to a normalized noise equivalent absorption coefficient of $5.1 \times {10^{- 9}}\;{\rm W}\;{{\rm cm}^{- 1}}\;{{\rm Hz}^{- 1/2}}$, potentially making the PAS sensor a truly disruptive instrument for bedside monitoring using isotope tracers by providing real-time metabolism data to clinical personnel.
© 2021 Optical Society of America
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