Designing phantoms to accurately replicate circular depolarization in biological scattering media

Callum M. Macdonald; Britt Kunnen; Cherie Stayner; Michael R. Eccles

doi:10.1364/AO.58.009577

Applied Optics
Vol. 58,
Issue 35,
pp. 9577-9584
(2019)
•https://doi.org/10.1364/AO.58.009577

Designing phantoms to accurately replicate circular depolarization in biological scattering media

Callum M. Macdonald, Britt Kunnen, Cherie Stayner, and Michael R. Eccles

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Callum M. Macdonald, Britt Kunnen, Cherie Stayner, and Michael R. Eccles, "Designing phantoms to accurately replicate circular depolarization in biological scattering media," Appl. Opt. 58, 9577-9584 (2019)

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Table of Contents Category
- Medical Optics, Microscopy, and Biotechnology
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About this Article
History
- Original Manuscript: September 3, 2019
- Revised Manuscript: October 21, 2019
- Manuscript Accepted: October 27, 2019
- Published: December 2, 2019

Abstract

We introduce an iterative method for designing optical phantoms that are able to replicate the depolarization profiles of various target media, including colloidal suspensions of Intralipid, bovine milk, and ex vivo samples of ovine kidney cortex tissue. The designed phantoms comprise spherical scattering particles with fine-tuned size distributions and are capable of simultaneously reproducing spatially resolved intensity measurements and depolarization measurements of target media when illuminated with circularly polarized light.

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Std. Sol.	Diameter (µm)	$g$	$γ_{c}$	$N_{c} / N_{t}$
1	0.088±0.01	0.0665	0.088068	0.4116
2	0.22±0.0176	0.4025	0.53976	0.9691
3	0.372±0.01	0.7283	0.92738	3.604
4	0.51±0.008	0.8256	0.96359	4.701
5	0.746±0.01	0.8918	0.98115	5.686
6	1.54±0.056	0.9317	0.98992	6.743
7	1.93±0.05	0.9206	0.98857	6.909
8	3.0±0.065	0.8210	0.97262	6.450

Match	Phantom	$g$	$N_{c} / N_{t}$	$a^{'}$	$μ_{s}^{'} ({m m}^{- 1})$
Intralipid	1	0.70	2.00	1.00	0.68
Milk	2	0.70	2.10	1.00	0.60

Match	Area	Phantom	$g$	$N_{c} / N_{t}$	$a^{'}$	$μ_{s}^{'} (m m^{- 1})$
Kidney 1	1	3	0.90	2.40	0.85	0.79
Kidney 1	2	4	0.90	2.40	0.85	0.81
Kidney 1	3	4	0.90	2.40	0.85	0.81
Kidney 2	1	5	0.90	2.60	0.88	0.84
Kidney 2	2	5	0.90	2.60	0.88	0.84
Kidney 2	3	6	0.80	2.40	0.87	0.81
Kidney 3	1	7	0.90	2.40	0.81	0.80
Kidney 3	2	8	0.90	2.60	0.82	0.79
Kidney 3	3	9	0.90	2.40	0.85	0.75
Kidney 4	1	10	0.90	2.40	0.87	0.87
Kidney 4	2	11	0.80	2.20	0.87	0.81
Kidney 4	3	12	0.80	2.20	0.87	0.77

Phantom	Components ( $μ L$ )
1	229.6 (2) + 181.4 (3) + 136.6 (4)+ 7452.4 (Water)
2	180.3 (2) + 203.1 (3) + 98.0 (4)+ 7518.6 (Water)
3	1061.7 (1) + 25.1 (4) + 663.7 (6)
	2240.0 (Trypan 1) + 4009.5 (Water)
4	1088.5 (1) + 25.8 (4) + 680.5 (6)
	2296.7 (Trypan 1) + 3908.5 (Water)
5	955.1 (1) + 62.4 (3) + 696.3 (6)
	1862.0 (Trypan 2) + 4424.0 (Water)
6	214.8 (2) + 199.4 (3) + 272.4 (5)
	1967.4 (Trypan 2) + 5345.9 (Water)
7	1075.1 (1) + 25.5 (4) + 672.1 (6)
	3050.4 (Trypan 2) + 3177.0 (Water)
8	898.2 (1) + 58.7 (3) + 655.1 (6)
	2818.9 (Trypan 2) + 3569.1 (Water)
9	1007.9 (1) + 23.9 (4) + 630.1 (6)
	2126.6 (Trypan 1) + 4211.5 (Water)
10	1169.2 (1) + 27.7 (4) + 730.9 (6)
	2088.8 (Trypan 1) + 3983.3 (Water)
11	263.2 (2) + 134.7 (3) + 293.3 (5)
	1944.7 (Trypan 1) + 5364.1 (Water)
12	250.2 (2) + 128.0 (3) + 278.9 (5)
	1847.9 (Trypan 1) + 5495.0 (Water)

Std. Sol.	Diameter (µm)	$g$	$γ_{c}$	$N_{c} / N_{t}$
1	0.088±0.01	0.0665	0.088068	0.4116
2	0.22±0.0176	0.4025	0.53976	0.9691
3	0.372±0.01	0.7283	0.92738	3.604
4	0.51±0.008	0.8256	0.96359	4.701
5	0.746±0.01	0.8918	0.98115	5.686
6	1.54±0.056	0.9317	0.98992	6.743
7	1.93±0.05	0.9206	0.98857	6.909
8	3.0±0.065	0.8210	0.97262	6.450

Abstract

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Applied Optics