Abstract

Noninvasive blood glucose determination has received considerable attention in the past from both patients and scientists all over the world, and it is becoming increasingly important as a research focus. The two most difficult problems leading to no breakthrough in this area are sensitivity and specificity in determination. In order to obtain reliable measurement results of blood glucose levels, we propose a new liquid photoacoustic resonance theory that can significantly enhance the intensity of the signal and improve the sensitivity. This paper demonstrates the theory of liquid photoacoustic resonance, gives a rigorous mathematical expression, and analyzes the variation of the transducer output in the case of liquid photoacoustic resonance. A signal processing method is demonstrated at the same time under the liquid photoacoustic resonance condition. Meanwhile, the feasibility and validity are verified by experiments with different concentrations of glucose solution. The result shows that liquid photoacoustic resonance can strengthen the signal, and the resolution achieves 20  mg/dL. This method overcomes the issue of low sensitivity and the inaccurate detection in the nonresonant case, and gets accurate results. This result could provide a theoretical basis for realization of noninvasive measurement of blood glucose.

© 2017 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Glucose sensing in oral mucosa simulating phantom using differential absorption based frequency domain low-coherence interferometry

Pauline John, Nilesh J. Vasa, Sujatha Narayanan Unni, and Suresh R. Rao
Appl. Opt. 56(29) 8257-8265 (2017)

Glucose sensing in human epidermis using mid-infrared photoacoustic detection

Jonas Kottmann, Julien M. Rey, Joachim Luginbühl, Ernst Reichmann, and Markus W. Sigrist
Biomed. Opt. Express 3(4) 667-680 (2012)

Noninvasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry

Xinxin Guo, Andreas Mandelis, and Bernard Zinman
Biomed. Opt. Express 3(11) 3012-3021 (2012)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (12)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (11)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription