Abstract

Interference-enhanced wide-field nanoparticle imaging is a highly sensitive technique that has found numerous applications in labeled and label-free subdiffraction-limited pathogen detection. It also provides unique opportunities for nanoparticle classification upon detection. More specifically, the nanoparticle defocus images result in a particle-specific response that can be of great utility for nanoparticle classification, particularly based on type and size. In this work, we combine a model-based supervised learning algorithm with a wide-field common-path interferometric microscopy method to achieve accurate nanoparticle classification. We verify our classification schemes experimentally by blindly detecting gold and polystyrene nanospheres, and then classifying them in terms of type and size.

© 2017 Optical Society of America

Full Article  |  PDF Article
More Like This
Pupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopy

Oguzhan Avci, Maria I. Campana, Celalettin Yurdakul, and M. Selim Ünlü
Optica 4(2) 247-254 (2017)

Resolution enhancement of wide-field interferometric microscopy by coupled deep autoencoders

Çağatay Işil, Mustafa Yorulmaz, Berkan Solmaz, Adil Burak Turhan, Celalettin Yurdakul, Selim Ünlü, Ekmel Ozbay, and Aykut Koç
Appl. Opt. 57(10) 2545-2552 (2018)

Quantitative interferometric reflectance imaging for the detection and measurement of biological nanoparticles

Derin Sevenler, Oğuzhan Avci, and M. Selim Ünlü
Biomed. Opt. Express 8(6) 2976-2989 (2017)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription