Abstract

A quantum weak measurement scheme based on a Mach–Zehnder interferometer is proposed to detect the concentration of glucose, bringing this mechanism into the field of biomedical sensing for the first time, to the best of our knowledge. With a Mach–Zehnder interferometer system, we can analyze tiny phase differences between the two paths by measuring spectrum shift. We measured the concentration of glucose with weak measurement to achieve a concentration resolution of 8.98×105  g/L corresponding to a volume refractive index of 1.39×108  RIU, which was more than five times higher than the resolution achieved by conventional interference, 4.99×104  g/L. In the detection of glucose concentration in the blood serum of mice, a resolution of 1.0136×107  g/L for weak measurement was obtained.

© 2016 Optical Society of America

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