Abstract

Gold nanoparticles have been investigated as contrast agents for traditional x-ray medical procedures, utilizing the strong absorption characteristics of the nanoparticles to enhance the contrast of the detected x-ray image. Here we use the Kramers–Kronig relation for complex atomic scattering factors to find the real and imaginary parts of the index of refraction for the medium composed of single-element materials or compounds in the x-ray range of the spectrum. These complex index of refraction values are then plugged into a Lorenz–Mie theory to calculate the absorption efficiency of various size gold nanoparticles for photon energies in the 1–100 keV range. Since the output from most medical diagnostic x-ray devices follows a wide and filtered spectrum of photon energies, we introduce and compute the effective intensity-absorption-efficiency values for gold nanoparticles of radii varying from 5 to 50 nm, where we use the TASMIP model to integrate over all spectral energies generated by typical tungsten anode x-ray tubes with kilovolt potentials ranging from 50 to 150 kVp.

© 2014 Optical Society of America

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