Abstract

The common approach in fluorescence molecular tomography (FMT) assumes homogeneous distributions of the optical properties and normally results in reconstructions of low sensitivity. A natural enhancement is to incorporate diffuse optical tomography (DOT) to FMT. However, the traditional voxel-based DOT has been a severely ill-posed inverse problem and cannot retrieve the optical property distributions accurately. We present a structural-prior-based DOT method to effectively acquire the heterogeneous optical background with the aid of some imperfect structural priors from x-ray computed tomography and/or magnetic resonance imaging anatomical imaging modalities, and quantitatively compare its hard- and soft-prior schemes for achieving an improved recovery of the fluorescence distribution. Numerical simulations are conducted on a region-labeled three-dimensional (3D) digital mouse model to investigate the performance of this method. Physical experiments on a cylindrical phantom are also conducted to assess this methodology. Our simulated and experimental reconstruction results indicate that the structural-prior-based DOT guided FMT approach can significantly improve the sensitivity of FMT reconstruction, as well as its imaging resolution and quantitative accuracy.

© 2014 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Shape-parameterized diffuse optical tomography holds promise for sensitivity enhancement of fluorescence molecular tomography

Linhui Wu, Wenbo Wan, Xin Wang, Zhongxing Zhou, Jiao Li, Limin Zhang, Huijuan Zhao, and Feng Gao
Biomed. Opt. Express 5(10) 3640-3659 (2014)

An adaptive support driven reweighted L1-regularization algorithm for fluorescence molecular tomography

Junwei Shi, Fei Liu, Huangsheng Pu, Simin Zuo, Jianwen Luo, and Jing Bai
Biomed. Opt. Express 5(11) 4039-4052 (2014)

Novel l2,1-norm optimization method for fluorescence molecular tomography reconstruction

Shixin Jiang, Jie Liu, Yu An, Guanglei Zhang, Jinzuo Ye, Yamin Mao, Kunshan He, Chongwei Chi, and Jie Tian
Biomed. Opt. Express 7(6) 2342-2359 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (11)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (8)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (15)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription