The ability to detect nanoparticles in extremely dilute solutions in the presence of environmental noise is crucial for biosensing applications. In this paper we propose a scheme for detecting target nanoparticles through their scattering effects in a high- whispering gallery microcavity. The detection signal, defined as the total linewidth broadening of the two new split modes that appear upon nanoparticle adsorption, is highly sensitive and proportional to the nanoparticle concentration. Furthermore, this new method of detection eliminates the requirement for strict temperature control and is capable of distinguishing the signal from the biorecognitions (e.g., antibodies) initially attached to the resonator and that from the target nanoparticles (e.g., antigens).
© 2013 Optical Society of AmericaFull Article | PDF Article
Jiangang Zhu, Şahin Kaya Özdemir, Lina He, Da-Ren Chen, and Lan Yang
Opt. Express 19(17) 16195-16206 (2011)
I. Fescenko, J. Alnis, A. Schliesser, C. Y. Wang, T. J. Kippenberg, and T. W. Hänsch
Opt. Express 20(17) 19185-19193 (2012)
Stephen Arnold, Venkata Ramanaiah Dantham, Curtis Barbre, Bruce A. Garetz, and Xudong Fan
Opt. Express 20(24) 26147-26159 (2012)