Abstract

In fluorescence molecular tomography (FMT), diffuse-light measurements are obtained from a series of source–detector pairs placed on the boundary of the medium. The sensitivity of measurements deteriorates quickly with increased distance from the sources and detectors and therefore yields poor depth quantitative recovery. A depth compensation algorithm is presented in this paper to reconstruct fluorescent inclusions in deep tissues. Two weight matrixes are employed to level off sensitivity differences and enhance prominent elements of the solution. Results of numerical and phantom experiments demonstrate that both relative quantitation and spatial resolution of FMT are improved for inclusions at different depths.

© 2012 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
An adaptive support driven reweighted L1-regularization algorithm for fluorescence molecular tomography

Junwei Shi, Fei Liu, Huangsheng Pu, Simin Zuo, Jianwen Luo, and Jing Bai
Biomed. Opt. Express 5(11) 4039-4052 (2014)

Subsurface fluorescence molecular tomography with prior information

Wei He, Huangsheng Pu, Guanglei Zhang, Xu Cao, Bin Zhang, Fei Liu, Jianwen Luo, and Jing Bai
Appl. Opt. 53(3) 402-409 (2014)

Reconstruction algorithm for fluorescence molecular tomography using sorted L-one penalized estimation

Xiaowei He, Fang Dong, Jingjing Yu, Hongbo Guo, and Yuqing Hou
J. Opt. Soc. Am. A 32(11) 1928-1935 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (8)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (4)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (10)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription