Abstract

A finite element method based on the full-vectorial H-field formulation has been employed to achieve the maximum field penetration in the sensing medium of the slot-waveguide-based ring resonator biosensor. The use of nanometer scale guiding structure where optical mode is confined in a low-index region permits a very compact sensor with high optical intensity in the region, which makes it possible to detect minimum refractive index change, and offers higher sensitivities. We analyze the change in effective refractive index of mode, sensitivity, and power confinement of the proposed slot-waveguide-based ring resonator biosensor for the detection of DNA hybridization. The biosensor exhibited theoretical sensitivity of 856 nm per refractive index unit (RIU) and a detection limit of 1.43×106RIU.

© 2012 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. B. J. Luff, R. D. Harris, J. S. Wilkinson, R. Wilson, and D. J. Schiffrin, “Integrated-optical directional coupler biosensor,” Opt. Lett. 21, 618–620 (1996).
    [CrossRef]
  2. F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
    [CrossRef]
  3. W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
    [CrossRef]
  4. C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
    [CrossRef]
  5. R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
    [CrossRef]
  6. N. Nath and A. Chilkoti, “Label-free biosensing by surface plasmon of nanoparticles on glass: optimization of nanoparticles size,” Anal. Chem. 76, 5370–5378 (2004).
    [CrossRef]
  7. V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
    [CrossRef]
  8. F. Dell’Olio and V. M. N. Passaro, “Optical sensing by optimized silicon slot waveguides,” Opt. Express 15, 4977–4993 (2007).
    [CrossRef]
  9. K. R. Hiremath, “Analytical modal analysis of bent slot waveguides,” J. Opt. Soc. Am. A 26, 2321–2326 (2009).
    [CrossRef]
  10. B. M. A. Rahman and J. B. Davies, “Finite element solution of integrated optical waveguides,” J. Lightwave Technol. 2, 682–688 (1984).
    [CrossRef]
  11. M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
    [CrossRef]
  12. X. Li, Z. Zhang, S. Qin, T. Wang, F. Liu, M. Qiu, and Y. Su, “Sensitive label-free and compact biosensor based on concentric silicon-on-insulator microring resonators,” Appl. Opt. 48, F90–F94 (2009).
    [CrossRef]
  13. T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).
  14. C. A. Barrios, M. J. Banuls, V. Gonzalez-Pedro, K. B. Gylfason, B. Sanchez, A. Griol, A. Maquieira, H. Sohlstrom, M. Holgado, and R. Casquel, “Label-free optical biosensing with slot-waveguides,” Opt. Lett. 33, 708–710 (2008).
    [CrossRef]
  15. C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
    [CrossRef]
  16. K. Palmer and D. Williams, “Optical properties of water in the near infrared,” J. Opt. Soc. Am. 64, 1107–1110 (1974).
    [CrossRef]
  17. X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
    [CrossRef]
  18. C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
    [CrossRef]

2010 (2)

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

2009 (4)

K. R. Hiremath, “Analytical modal analysis of bent slot waveguides,” J. Opt. Soc. Am. A 26, 2321–2326 (2009).
[CrossRef]

X. Li, Z. Zhang, S. Qin, T. Wang, F. Liu, M. Qiu, and Y. Su, “Sensitive label-free and compact biosensor based on concentric silicon-on-insulator microring resonators,” Appl. Opt. 48, F90–F94 (2009).
[CrossRef]

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

2008 (2)

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

C. A. Barrios, M. J. Banuls, V. Gonzalez-Pedro, K. B. Gylfason, B. Sanchez, A. Griol, A. Maquieira, H. Sohlstrom, M. Holgado, and R. Casquel, “Label-free optical biosensing with slot-waveguides,” Opt. Lett. 33, 708–710 (2008).
[CrossRef]

2007 (1)

2006 (1)

C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
[CrossRef]

2005 (1)

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

2004 (1)

N. Nath and A. Chilkoti, “Label-free biosensing by surface plasmon of nanoparticles on glass: optimization of nanoparticles size,” Anal. Chem. 76, 5370–5378 (2004).
[CrossRef]

2003 (1)

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

2002 (1)

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

2001 (1)

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

1996 (1)

1984 (1)

B. M. A. Rahman and J. B. Davies, “Finite element solution of integrated optical waveguides,” J. Lightwave Technol. 2, 682–688 (1984).
[CrossRef]

1974 (1)

Abad, A.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Armenise, M. N.

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

Baets, R.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Banuls, M. J.

Banuls Polo, M. J.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Barrios, C. A.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

C. A. Barrios, M. J. Banuls, V. Gonzalez-Pedro, K. B. Gylfason, B. Sanchez, A. Griol, A. Maquieira, H. Sohlstrom, M. Holgado, and R. Casquel, “Label-free optical biosensing with slot-waveguides,” Opt. Lett. 33, 708–710 (2008).
[CrossRef]

Biaggio, I.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Bienstman, P.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

Bogaerts, W.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Calle, A.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Carlborg, C. F.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Casquel, R.

Catala, A. M.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Chao, C. Y.

C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
[CrossRef]

Chilkoti, A.

N. Nath and A. Chilkoti, “Label-free biosensing by surface plasmon of nanoparticles on glass: optimization of nanoparticles size,” Anal. Chem. 76, 5370–5378 (2004).
[CrossRef]

Ciminelli, C.

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

Claes, T.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

Coombe, E. R.

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

Davies, J. B.

B. M. A. Rahman and J. B. Davies, “Finite element solution of integrated optical waveguides,” J. Lightwave Technol. 2, 682–688 (1984).
[CrossRef]

De La Rue, R. M.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

De Vos, K.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

Dell’Olio, F.

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

F. Dell’Olio and V. M. N. Passaro, “Optical sensing by optimized silicon slot waveguides,” Opt. Express 15, 4977–4993 (2007).
[CrossRef]

Diederich, F.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Domynguez, C.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Dortu, F.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Driessen, A.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Dumon, P.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Esembeson, B.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Fan, X.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Freude, W.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Fung, W.

C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
[CrossRef]

Gonzalez-Pedro, V.

Griol, A.

Guo, L. J.

C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
[CrossRef]

Gylfason, K. B.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

C. A. Barrios, M. J. Banuls, V. Gonzalez-Pedro, K. B. Gylfason, B. Sanchez, A. Griol, A. Maquieira, H. Sohlstrom, M. Holgado, and R. Casquel, “Label-free optical biosensing with slot-waveguides,” Opt. Lett. 33, 708–710 (2008).
[CrossRef]

Harris, R. D.

Hiremath, K. R.

Holgado, M.

Hopman, W. C. L.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Kazmierczak, A.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Kelly, K. L.

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

Kett, W. C.

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

Koos, C.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Kresbach, G. M.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Lambeck, P. V.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Lechuga, L. M.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Leuthold, J.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Li, X.

Liu, F.

Llobera, A.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Luff, B. J.

Malinsky, M. D.

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

Maquieira, A.

Michinobu, T.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Moh, T.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Molera, J. G.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

Montoya, A.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Nath, N.

N. Nath and A. Chilkoti, “Label-free biosensing by surface plasmon of nanoparticles on glass: optimization of nanoparticles size,” Anal. Chem. 76, 5370–5378 (2004).
[CrossRef]

Osmond, R. I. W.

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

Palmer, K.

Passaro, V. M. N.

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

F. Dell’Olio and V. M. N. Passaro, “Optical sensing by optimized silicon slot waveguides,” Opt. Express 15, 4977–4993 (2007).
[CrossRef]

Popplewell, J.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Pottier, P.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Prieto, F.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Qin, S.

Qiu, M.

Rahman, B. M. A.

B. M. A. Rahman and J. B. Davies, “Finite element solution of integrated optical waveguides,” J. Lightwave Technol. 2, 682–688 (1984).
[CrossRef]

Ronan, G.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Sanchez, B.

Schacht, E.

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

Schatz, G. C.

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

Schiffrin, D. J.

Sepulveda, B.

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Shopova, S. I.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Skett, S. E.

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

Sohlstrom, H.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

C. A. Barrios, M. J. Banuls, V. Gonzalez-Pedro, K. B. Gylfason, B. Sanchez, A. Griol, A. Maquieira, H. Sohlstrom, M. Holgado, and R. Casquel, “Label-free optical biosensing with slot-waveguides,” Opt. Lett. 33, 708–710 (2008).
[CrossRef]

Stemme, G.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Su, Y.

Sun, Y.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Suter, J. D.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Vallaitis, T.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

van der Wijngaart, W.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Van Duyne, R. P.

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

van Lith, J.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Vivien, L.

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Vorreau, P.

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Wang, T.

White, I. M.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Wilkinson, J. S.

Williams, D.

Wilson, R.

Yudistira, D.

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

Zhang, Z.

Zhu, H.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Anal. Biochem. (1)

R. I. W. Osmond, W. C. Kett, S. E. Skett, and E. R. Coombe, “Protein heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization,” Anal. Biochem. 310, 199–207 (2002).
[CrossRef]

Anal. Chem. (1)

N. Nath and A. Chilkoti, “Label-free biosensing by surface plasmon of nanoparticles on glass: optimization of nanoparticles size,” Anal. Chem. 76, 5370–5378 (2004).
[CrossRef]

Anal. Chim. Acta (1)

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: A review,” Anal. Chim. Acta 620, 8–26 (2008).
[CrossRef]

Appl. Opt. (1)

IEEE J. Sel. Top. Quantum Electron. (2)

W. C. L. Hopman, P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, and A. Driessen, “Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors,” IEEE J. Sel. Top. Quantum Electron. 11, 11–16 (2005).
[CrossRef]

C. Y. Chao, W. Fung, and L. J. Guo, “Polymer microring resonators for biochemical sensing applications,” IEEE J. Sel. Top. Quantum Electron. 12, 134–142 (2006).
[CrossRef]

IEEE Photonics J. (1)

T. Claes, J. G. Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, “Label-free biosensing with a slot waveguide based ring resonator in silicon on insulator,” IEEE Photonics J. 1, 197–204 (2009).

J. Am. Chem. Soc. (1)

M. D. Malinsky, K. L. Kelly, G. C. Schatz, and R. P. Van Duyne, “Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayers,” J. Am. Chem. Soc. 123, 1471–1482 (2001).
[CrossRef]

J. Lightwave Technol. (1)

B. M. A. Rahman and J. B. Davies, “Finite element solution of integrated optical waveguides,” J. Lightwave Technol. 2, 682–688 (1984).
[CrossRef]

J. Opt. Soc. Am. (1)

J. Opt. Soc. Am. A (1)

Lab Chip (1)

C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Banuls Polo, A. M. Catala, G. M. Kresbach, H. Sohlstrom, T. Moh, L. Vivien, J. Popplewell, G. Ronan, C. A. Barrios, G. Stemme, and W. van der Wijngaart, “A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips,” Lab Chip 10, 281–290 (2010).
[CrossRef]

Nanotechnology (1)

F. Prieto, B. Sepulveda, A. Calle, A. Llobera, C. Domynguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology 14, 907–912 (2003).
[CrossRef]

Nat. Photonics (1)

C. Koos, P. Vorreau, T. Vallaitis, P. Dumon, W. Bogaerts, R. Baets, B. Esembeson, I. Biaggio, T. Michinobu, F. Diederich, W. Freude, and J. Leuthold, “All-optical high-speed signal processing with silicon-organic hybrid slot waveguides,” Nat. Photonics 3, 216–219 (2009).
[CrossRef]

Opt. Express (1)

Opt. Lett. (2)

Sens. Actuators B Chem. (1)

V. M. N. Passaro, F. Dell’Olio, C. Ciminelli, and M. N. Armenise, “Efficient chemical sensing by coupled slot SOI waveguides,” Sens. Actuators B Chem. 150, 417–424 (2010).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (14)

Fig. 1.
Fig. 1.

Slot waveguide biosensor.

Fig. 2.
Fig. 2.

Hy field of the Hy11 mode.

Fig. 3.
Fig. 3.

Hy contour of Hy11 mode.

Fig. 4.
Fig. 4.

Variations of the effective index, neff, with the slot width for TE mode.

Fig. 5.
Fig. 5.

Variation of effective index difference, δneff and waveguide sensitivity with guide width.

Fig. 6.
Fig. 6.

Variation of effective index difference, δneff and waveguide sensitivity with slot width.

Fig. 7.
Fig. 7.

Variation of effective index difference, δneff and waveguide sensitivity with guide height.

Fig. 8.
Fig. 8.

Variation of effective index with wavelength.

Fig. 9.
Fig. 9.

Variation of wavelength shift with slot width.

Fig. 10.
Fig. 10.

Variation of wavelength shift with guide width.

Fig. 11.
Fig. 11.

Power confinement factor in (a) ssDNA layer and (b) dsDNA layer.

Fig. 12.
Fig. 12.

Variation of power density in DNA layer with the slot width for TE mode.

Fig. 13.
Fig. 13.

Variation of power density in DNA layer with the guide width for TE mode.

Fig. 14.
Fig. 14.

Variation of power density in DNA layer with the guide height for TE mode.

Equations (6)

Equations on this page are rendered with MathJax. Learn more.

ω2=[(×H)*·ε1(×H)+p(·H)*(·H)]dxdyH*·μHdxdy,
S=δneff/RI,
S=δλ/δn,
δλ=δneff*λres/ng,
R=3σ=1.2pm.
Sz=Ω{E×H}dxdy.

Metrics