Abstract

In this work we have replaced a commonly used Au film with an Au/Ag bimetallic film working as the sensing chip in the commercial surface plasmon resonance (SPR) instrument, Biacore 3000. The bimetallic chip gives out sharper SPR dip than that by the chip made of an Au film. The applicability and stability of the bimetallic chip on the Biacore 3000 are tested by real-time monitoring of biological coupling processes between sulfamethoxazole (SMX) and anti-SMX, which is useful in rapid detection of contaminations in food products. The bimetallic chip performs stably in 6 times’ usage and regeneration. Our experiment is helpful to push the bimetallic film into real applications in commercial SPR instruments.

© 2011 Optical Society of America

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References

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  1. B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
    [CrossRef]
  2. J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev. 108, 462–493(2008).
    [CrossRef] [PubMed]
  3. www.biacore.com.
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    [CrossRef]
  5. www.thermo.com.cn.
  6. T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
    [CrossRef] [PubMed]
  7. M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
    [CrossRef]
  8. K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
    [CrossRef] [PubMed]
  9. W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
    [CrossRef]
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    [CrossRef]
  14. X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
    [CrossRef]
  15. Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
    [CrossRef]
  16. J. Homola and M. Piliarik, Surface Plasmon Resonance Based Sensors (Springer Verlag, 2006).
    [CrossRef]
  17. S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
    [CrossRef]
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    [CrossRef] [PubMed]

2008 (2)

J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev. 108, 462–493(2008).
[CrossRef] [PubMed]

A. Lahav, M. Auslender, and I. Abdulhalim, “Sensitivity enhancement of guided-wave surface plasmon resonance sensors,” Opt. Lett. 33, 2539–2541 (2008).
[CrossRef] [PubMed]

2007 (2)

K. M. Byun, S. J. Yoon, D. Kim, and S. J. Kim, “Experimental study of sensitivity enhancement in surface plasmon resonance biosensors by use of periodic metallic nanowires,” Opt. Lett. 32, 1902–1904 (2007).
[CrossRef] [PubMed]

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

2006 (3)

S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
[CrossRef]

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
[CrossRef]

2005 (1)

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

2003 (2)

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

2002 (2)

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

2001 (1)

K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
[CrossRef] [PubMed]

1998 (1)

L. A. Lyon, M. D. Musick, and M. J. Natan, “Colloidal Au-enhanced surface plasmon resonance immunosensing,” Anal. Chem. 70, 5177–5183 (1998).
[CrossRef] [PubMed]

1984 (1)

1983 (1)

B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
[CrossRef]

Abdulhalim, I.

Auslender, M.

Bartholomew, D. U.

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Brady, L. J.

M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
[CrossRef]

Bu, J.

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

Byun, K. M.

Cazemier, G.

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

Chang, S.-H.

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

Chilwell, J.

Chinowsky, T. M.

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Elkind, J. L.

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Haasnoot, W.

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

Hodgkinson, I.

Homola, J.

J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev. 108, 462–493(2008).
[CrossRef] [PubMed]

J. Homola and M. Piliarik, Surface Plasmon Resonance Based Sensors (Springer Verlag, 2006).
[CrossRef]

Irawan, R.

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

Isobe, T.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Kaiser, R.

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Kim, D.

Kim, S. J.

Koets, M.

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

Kume, S.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Lahav, A.

Liedberg, B.

B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
[CrossRef]

Lundstrom, I.

B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
[CrossRef]

Lyon, L. A.

L. A. Lyon, M. D. Musick, and M. J. Natan, “Colloidal Au-enhanced surface plasmon resonance immunosensing,” Anal. Chem. 70, 5177–5183 (1998).
[CrossRef] [PubMed]

Manki, H.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

McArthur, W. P.

M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
[CrossRef]

Mikoshiba, K.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Mirsky, V. M.

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

Musick, M. D.

L. A. Lyon, M. D. Musick, and M. J. Natan, “Colloidal Au-enhanced surface plasmon resonance immunosensing,” Anal. Chem. 70, 5177–5183 (1998).
[CrossRef] [PubMed]

Nakatani, K.

K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
[CrossRef] [PubMed]

Natan, M. J.

L. A. Lyon, M. D. Musick, and M. J. Natan, “Colloidal Au-enhanced surface plasmon resonance immunosensing,” Anal. Chem. 70, 5177–5183 (1998).
[CrossRef] [PubMed]

Natsume, T.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Nylander, C.

B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
[CrossRef]

Oli, M. W.

M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
[CrossRef]

Ong, B. H.

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

Piliarik, M.

J. Homola and M. Piliarik, Surface Plasmon Resonance Based Sensors (Springer Verlag, 2006).
[CrossRef]

Quinn, J. G.

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Saito, I.

K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
[CrossRef] [PubMed]

Samoylov, A. V.

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

Sando, S.

K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
[CrossRef] [PubMed]

Schatz, G. C.

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

Sherry, L. J.

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

Shirshov, Y. M.

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

Tan, Y. G.

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

Tan, Y. Y.

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

Taoka, M.

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Tjin, S. C.

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

van Amerongen, A.

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

Van Duyne, R. P.

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

Wang, L.

S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
[CrossRef]

Wang, S.

S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
[CrossRef]

Yoon, S. J.

Yuan, X.-C.

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

Zhang, D. W.

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

Zhang, H. Y.

S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
[CrossRef]

Zynio, S. A.

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

Anal. Chem. (1)

L. A. Lyon, M. D. Musick, and M. J. Natan, “Colloidal Au-enhanced surface plasmon resonance immunosensing,” Anal. Chem. 70, 5177–5183 (1998).
[CrossRef] [PubMed]

Anal. Chim. Acta (1)

W. Haasnoot, G. Cazemier, M. Koets, and A. van Amerongen, “Single biosensor immunoassay for the detection of five aminoglycosides in reconstituted skimmed milk,” Anal. Chim. Acta 488, 53–60 (2003).
[CrossRef]

Appl. Phys. Lett. (1)

Y. Y. Tan, X.-C. Yuan, B. H. Ong, and J. Bu, “Two layered metallic film induced surface plasons for enhanced optical propulsion of microparticles,” Appl. Phys. Lett. 91, 141108(2007).
[CrossRef]

Chem. Rev. (1)

J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev. 108, 462–493(2008).
[CrossRef] [PubMed]

Food Add. Contaminants (1)

S. Wang, H. Y. Zhang, and L. Wang, “Analysis of sulphonamide residues in edible animal products: a review,” Food Add. Contaminants 23, 362–384 (2006).
[CrossRef]

J. Microbiol. Meth. (1)

M. W. Oli, W. P. McArthur, and L. J. Brady, “A whole cell BIAcore assay to evaluate P1-mediated adherence of Streptococcus mutans to human salivary agglutinin and inhibition by specific antibodies,” J. Microbiol. Meth. 65, 503–511 (2006).
[CrossRef]

J. Opt. A: Pure Appl. Opt. (1)

X.-C. Yuan, B. H. Ong, Y. G. Tan, D. W. Zhang, R. Irawan, and S. C. Tjin, “Sensitivity–stability-optimized surface plasmon resonance sensing with double metal layers,” J. Opt. A: Pure Appl. Opt. 8, 959–963 (2006).
[CrossRef]

J. Opt. Soc. Am. A (1)

Nano Lett. (1)

L. J. Sherry, S.-H. Chang, G. C. Schatz, and R. P. Van Duyne, “Localized surface plasmon resonance spectroscopy of single silver nanocubes,” Nano Lett. 5, 2034–2038 (2005).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

K. Nakatani, S. Sando, and I. Saito, “Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance,” Nat. Biotechnol. 19, 51–55 (2001).
[CrossRef] [PubMed]

Opt. Lett. (2)

Proteomics (1)

T. Natsume, M. Taoka, H. Manki, S. Kume, T. Isobe, and K. Mikoshiba, “Rapid analysis of protein interactions: On-chip micropurification of recombinant protein expressed in Esherichia coli,” Proteomics 2, 1247–1253 (2002).
[CrossRef] [PubMed]

Sens. Actuators (1)

B. Liedberg, C. Nylander, and I. Lundstrom, “Surface plasmon resonance for gas detection and biosensing,” Sens. Actuators 4, 299–304 (1983).
[CrossRef]

Sens. Actuators B (1)

T. M. Chinowsky, J. G. Quinn, D. U. Bartholomew, R. Kaiser, and J. L. Elkind, “Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor,” Sens. Actuators B 91, 266–274 (2003).
[CrossRef]

Sensors (1)

S. A. Zynio, A. V. Samoylov, and V. M. Mirsky, and Y. M. Shirshov, “Bimetallic layers increase sensitivity of affinity sensors based on surface Plasmon resonance,” Sensors 2, 62–70 (2002).
[CrossRef]

Other (3)

J. Homola and M. Piliarik, Surface Plasmon Resonance Based Sensors (Springer Verlag, 2006).
[CrossRef]

www.thermo.com.cn.

www.biacore.com.

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Figures (6)

Fig. 1
Fig. 1

The FOM factor versus the percentage of thickness of Ag film in the total thickness of the bimetallic film.

Fig. 2
Fig. 2

AFM pictures of the surface roughness of a single Au film and a bimetallic film. (a) Au film of 50 nm thickness. (b) Bimetallic film comprised of a 40 nm thick Ag film and a 10 nm thick Ag film. The Au film is on the top.

Fig. 3
Fig. 3

Experimental SPR curves from a single Au layer and bimetallic layers chip.

Fig. 4
Fig. 4

Sensor graph from one analysis cycle showing the binding of anti-SMX with SMX on the bimetallic chip and the regeneration of the bimetallic chip surface. 1Ru means 10 6 ° .

Fig. 5
Fig. 5

Binding between SMX and anti-SMX with different concentrations [ 20 μ g / ml ( 1 50 ), 10 μ g / ml ( 1 100 ), and 4 μ g / ml ( 1 250 )].

Fig. 6
Fig. 6

Sensor graph from the bimetallic chip at the concentration of 4 μ g / ml for 6 times’ flows.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

r c s = γ c M 11 + γ c γ s M 12 ( M 21 + γ s M 22 ) γ c M 11 + γ c γ s M 12 + ( M 21 + γ s M 22 ) , R = | r c s | 2 ,
t c s = 2 γ c γ c M 11 + γ c γ s M 12 + ( M 21 + γ s M 22 ) , T = Re ( γ s ) Re ( γ c ) | t c s | 2 .
FOM = Δ θ r / Δ n s FWHM .

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