Abstract

An on-chip optical trapping and sorting system composed of a microchamber and a microlens array (MLA) is demonstrated. The MLA focuses the incident light into multiple confocal spots to trap the particles within the microchamber. The SiO2/ZrO2 solgel material is introduced in the fabrication of MLA for its unique optical and chemical characters. Moreover, in order to prove the effectiveness of the system, experimental demonstration of multibeam trapping and locked-in transport of micropolymer particles in the microchamber is implemented. The system may easily be integrated as microfluidic devices, offering a simple and efficient solution for optical trapping and sorting of biological particles in lab-on-a-chip technologies.

© 2011 Optical Society of America

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  1. A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
    [CrossRef] [PubMed]
  2. A. Ashikin, “History of optical trapping and manipulation of small-neutral particles, atoms, molecules,” IEEE J. Sel. Top. Quantum Electron. 6, 841–856 (2000).
    [CrossRef]
  3. A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
    [CrossRef]
  4. J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
    [CrossRef]
  5. A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
    [CrossRef] [PubMed]
  6. X. Miao, B. K. Wilson, S. H. Pun, and L. Y. Lin, “Optical manipulation of micron/submicron sized particles and biomolecules through plasmonics,” Opt. Express 16, 13517–13525(2008).
    [CrossRef] [PubMed]
  7. H. Tsutsui and C.-M. Ho, “Cell separation by non-inertial force fields in microfluidic systems,” Mech. Res. Commun. 36, 92–103 (2009).
    [CrossRef]
  8. H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
    [CrossRef] [PubMed]
  9. S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
    [CrossRef] [PubMed]
  10. S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
    [CrossRef] [PubMed]
  11. A. H. J. Yang and D. Erickson, “Optofluidic ring resonator switch for optical particle transport,” Lab Chip 10, 769–774(2010).
    [CrossRef] [PubMed]
  12. B. S. Schmidt, A. H. Yang, D. Erickson, and M. Lipson, “Optofluidic trapping and transport on solid core waveguides within a microfluidic device,” Opt. Express 15, 14322–14334 (2007).
    [CrossRef] [PubMed]
  13. F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).
  14. F. Merenda, J. Rohner, J.-M. Fournier, and R.-P. Salathé, “Miniaturized high-NA focusing-mirror multiple optical tweezers,” Opt. Express 15, 6075–6086 (2007).
    [CrossRef] [PubMed]
  15. Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
    [CrossRef]
  16. X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
    [CrossRef]
  17. F. Zhao, Y. Xie, S. He, S. Fu, and Z. Lu, “Single step fabrication of microlens arrays with hybrid HfO2–SiO2 sol-gel glass on conventional lens surface,” Opt. Express 13, 5846–5852(2005).
    [CrossRef] [PubMed]

2010 (2)

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

A. H. J. Yang and D. Erickson, “Optofluidic ring resonator switch for optical particle transport,” Lab Chip 10, 769–774(2010).
[CrossRef] [PubMed]

2009 (4)

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

H. Tsutsui and C.-M. Ho, “Cell separation by non-inertial force fields in microfluidic systems,” Mech. Res. Commun. 36, 92–103 (2009).
[CrossRef]

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

2008 (1)

2007 (3)

2006 (1)

Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
[CrossRef]

2005 (3)

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

F. Zhao, Y. Xie, S. He, S. Fu, and Z. Lu, “Single step fabrication of microlens arrays with hybrid HfO2–SiO2 sol-gel glass on conventional lens surface,” Opt. Express 13, 5846–5852(2005).
[CrossRef] [PubMed]

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

2002 (1)

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
[CrossRef]

2000 (1)

A. Ashikin, “History of optical trapping and manipulation of small-neutral particles, atoms, molecules,” IEEE J. Sel. Top. Quantum Electron. 6, 841–856 (2000).
[CrossRef]

1987 (1)

A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
[CrossRef] [PubMed]

Arakawa, T.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Ashikin, A.

A. Ashikin, “History of optical trapping and manipulation of small-neutral particles, atoms, molecules,” IEEE J. Sel. Top. Quantum Electron. 6, 841–856 (2000).
[CrossRef]

Ashkin, A.

A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
[CrossRef] [PubMed]

Casaburi, A.

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

Cheong, W. C.

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

Curtis, J. E.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
[CrossRef]

Deamer, D. W.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Dziedzic, J. M.

A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
[CrossRef] [PubMed]

Erickson, D.

A. H. J. Yang and D. Erickson, “Optofluidic ring resonator switch for optical particle transport,” Lab Chip 10, 769–774(2010).
[CrossRef] [PubMed]

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

B. S. Schmidt, A. H. Yang, D. Erickson, and M. Lipson, “Optofluidic trapping and transport on solid core waveguides within a microfluidic device,” Opt. Express 15, 14322–14334 (2007).
[CrossRef] [PubMed]

Fournier, J.-M.

F. Merenda, J. Rohner, J.-M. Fournier, and R.-P. Salathé, “Miniaturized high-NA focusing-mirror multiple optical tweezers,” Opt. Express 15, 6075–6086 (2007).
[CrossRef] [PubMed]

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

Fu, S.

Funatsu, T.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Grier, D. G.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
[CrossRef]

Hawkins, A. R.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

He, M.

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

He, S.

Ho, C.-M.

H. Tsutsui and C.-M. Ho, “Cell separation by non-inertial force fields in microfluidic systems,” Mech. Res. Commun. 36, 92–103 (2009).
[CrossRef]

Klug, M.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

Koss, B. A.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
[CrossRef]

Kuhn, S.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Lamothe, E.

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

Lin, L. Y.

Lipson, M.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

B. S. Schmidt, A. H. Yang, D. Erickson, and M. Lipson, “Optofluidic trapping and transport on solid core waveguides within a microfluidic device,” Opt. Express 15, 14322–14334 (2007).
[CrossRef] [PubMed]

Lu, Z.

Lunt, E. J.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Measor, P.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Merenda, F.

F. Merenda, J. Rohner, J.-M. Fournier, and R.-P. Salathé, “Miniaturized high-NA focusing-mirror multiple optical tweezers,” Opt. Express 15, 6075–6086 (2007).
[CrossRef] [PubMed]

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

Miao, X.

Moore, S. D.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

Murase, T.

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

Ohashi, T.

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

Ong, L. S.

Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
[CrossRef]

Ozaki, K.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Pascoal, P.

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

Pesce, G.

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

Phillips, B. S.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Pun, S. H.

Rohner, J.

F. Merenda, J. Rohner, J.-M. Fournier, and R.-P. Salathé, “Miniaturized high-NA focusing-mirror multiple optical tweezers,” Opt. Express 15, 6075–6086 (2007).
[CrossRef] [PubMed]

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

Sakamoto, N.

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

Salathé, R.-P.

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

F. Merenda, J. Rohner, J.-M. Fournier, and R.-P. Salathé, “Miniaturized high-NA focusing-mirror multiple optical tweezers,” Opt. Express 15, 6075–6086 (2007).
[CrossRef] [PubMed]

Sasso, A.

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

Sato, M.

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

Schmidt, B. S.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

B. S. Schmidt, A. H. Yang, D. Erickson, and M. Lipson, “Optofluidic trapping and transport on solid core waveguides within a microfluidic device,” Opt. Express 15, 14322–14334 (2007).
[CrossRef] [PubMed]

Schmidt, H.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

Shirasaki, Y.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Shoji, S.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Sugino, H.

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

Sugita, S.

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

Sun, Y. Y.

Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
[CrossRef]

Tsutsui, H.

H. Tsutsui and C.-M. Ho, “Cell separation by non-inertial force fields in microfluidic systems,” Mech. Res. Commun. 36, 92–103 (2009).
[CrossRef]

Wilson, B. K.

Xie, Y.

Yamane, T.

A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
[CrossRef] [PubMed]

Yang, A. H.

Yang, A. H. J.

A. H. J. Yang and D. Erickson, “Optofluidic ring resonator switch for optical particle transport,” Lab Chip 10, 769–774(2010).
[CrossRef] [PubMed]

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

Yu, W. X.

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

Yuan, X.-C.

Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
[CrossRef]

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

Zemanek, P.

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

Zhao, F.

Appl. Phys. Lett. (2)

Y. Y. Sun, L. S. Ong, and X.-C. Yuan, “Composite-microlens-array enabled microfluidic sorting,” Appl. Phys. Lett. 89, 141108 (2006).
[CrossRef]

X.-C. Yuan, W. X. Yu, M. He, and W. C. Cheong, “Soft-lithography-enabled fabrication of large numerical aperture refractive microlens array in hybrid SiO2–TiO2 sol-gel glass,” Appl. Phys. Lett. 86, 114102 (2005).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

A. Ashikin, “History of optical trapping and manipulation of small-neutral particles, atoms, molecules,” IEEE J. Sel. Top. Quantum Electron. 6, 841–856 (2000).
[CrossRef]

Lab Chip (4)

H. Sugino, K. Ozaki, Y. Shirasaki, T. Arakawa, S. Shoji, and T. Funatsu, “On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation,” Lab Chip 9, 1254–1260 (2009).
[CrossRef] [PubMed]

S. Sugita, T. Murase, N. Sakamoto, T. Ohashi, and M. Sato, “Size sorting of kinesin-driven microtubules with topographical grooves on a chip,” Lab Chip 10, 755–761 (2010).
[CrossRef] [PubMed]

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, “Loss-based optical trap for on-chip particle analysis,” Lab Chip 9, 2212–2216 (2009).
[CrossRef] [PubMed]

A. H. J. Yang and D. Erickson, “Optofluidic ring resonator switch for optical particle transport,” Lab Chip 10, 769–774(2010).
[CrossRef] [PubMed]

Mech. Res. Commun. (1)

H. Tsutsui and C.-M. Ho, “Cell separation by non-inertial force fields in microfluidic systems,” Mech. Res. Commun. 36, 92–103 (2009).
[CrossRef]

Nature (2)

A. Ashkin, J. M. Dziedzic, and T. Yamane, “Optical trapping and manipulation of single cells using infrared laser beams,” Nature 330, 769–771 (1987).
[CrossRef] [PubMed]

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, “Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides,” Nature 457, 71–75 (2009).
[CrossRef] [PubMed]

Opt. Commun. (2)

A. Casaburi, G. Pesce, P. Zemanek, and A. Sasso, “Two- and three-beam interferometric optical tweezers,” Opt. Commun. 251, 393–404 (2005).
[CrossRef]

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207, 169–175 (2002).
[CrossRef]

Opt. Express (4)

Proc. SPIE (1)

F. Merenda, J. Rohner, E. Lamothe, P. Pascoal, J.-M. Fournier, and R.-P. Salathé, “Micro-optics for optical trapping in microfluidics,” Proc. SPIE 6644, 6640–6649 (2007).

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Figures (8)

Fig. 1
Fig. 1

Schematic of on-chip optical trapping using MLA.

Fig. 2
Fig. 2

Measured calibration curve showing the dependence of the SiO 2 / ZrO 2 solgel film thickness on the AOM value.

Fig. 3
Fig. 3

SEM photo of fabricated MLA.

Fig. 4
Fig. 4

MLA-enabled on-chip optical trapping and sorting system.

Fig. 5
Fig. 5

Schematic of individual microlens.

Fig. 6
Fig. 6

On-chip multiple optical trapping of 3.1 μm polymer particles.

Fig. 7
Fig. 7

Sequential images of motions of mixed particles taken with 0.5 s intervals.

Fig. 8
Fig. 8

Trajectories of the 3.1 μm polystyrene particles being locked-in transported.

Equations (2)

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R = D 2 + 4 h 2 8 h ,
n 2 R = ( n 1 n 2 ) f ,

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