Abstract

We report a method of using optical aperture diffraction to simultaneously detect the image and the refractive index of a living cell. By simulation, it is found that, when a suitable gap is introduced between the cell and the aperture, the image of the cell on the detection plane can be amplified hundreds to thousands of times, and a limit of detection of 3e-4 to 9e-5 can be reached for the refractive index of the cell. Experiments show that this method is feasible to realize, but the achievement of such a detection system is yet to be proved.

© 2010 Optical Society of America

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