Abstract

A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45cc fluorescing target(s) (with 10 contrast ratio) of 1.5 to 2.5cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.

© 2010 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies

Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty
Appl. Opt. 48(33) 6408-6416 (2009)

Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies

Manuela Roman, Jean Gonzalez, Jennifer Carrasquilla, Sarah J. Erickson, Rad Akhter, and Anuradha Godavarty
Appl. Opt. 52(33) 8060-8066 (2013)

Fluorescence tomography characterization for sub-surface imaging with protoporphyrin IX

Dax Kepshire, Scott C. Davis, Hamid Dehghani, Keith D. Paulsen, and Brian W. Pogue
Opt. Express 16(12) 8581-8593 (2008)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (9)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription