Abstract

A theory is derived to describe the relationship between photonic crystal (PC) label-free imaging resolution and PC resonance spectral linewidth and location. PCs are fabricated and patterned with a res olution standard photomask in order to verify this relationship experimentally. Two distinct linear resolutions of <1μm and 3.5μm are demonstrated in orthogonal directions on a single device, where the former is limited by the imaging system optics and the latter is constrained by finite resonant mode propagation. In order to illustrate the utility of improved design control, the spectral response of a PC is optimized for label-free imaging of immobilized DNA capture spots on a microarray.

© 2009 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces

Ian D. Block, Patrick C. Mathias, Nikhil Ganesh, Sarah I. Jones, Brian R. Dorvel, Vikram Chaudhery, Lila O. Vodkin, Rashid Bashir, and Brian T. Cunningham
Opt. Express 17(15) 13222-13235 (2009)

Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays

Vikram Chaudhery, Cheng-Sheng Huang, Anusha Pokhriyal, James Polans, and Brian T. Cunningham
Opt. Express 19(23) 23327-23340 (2011)

Combined enhanced fluorescence and label-free biomolecular detection with a photonic crystal surface

Patrick C. Mathias, Nikhil Ganesh, Leo L. Chan, and Brian T. Cunningham
Appl. Opt. 46(12) 2351-2360 (2007)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (4)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription