Abstract

Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.

© 2009 Optical Society of America

Full Article  |  PDF Article
Related Articles
Bio-molecule-conjugated fluorescent organically modified silica nanoparticles as optical probes for cancer cell imaging

Jun Qian, Xin Li, Ming Wei, Xiangwei Gao, Zhengping Xu, and Sailing He
Opt. Express 16(24) 19568-19578 (2008)

Tailoring the soliton output of a photonic crystal fiber for enhanced two-photon excited luminescence response from fluorescent protein biomarkers and neuron activity reporters

Lyubov V. Doronina, Il'ya V. Fedotov, Aleksandr A. Voronin, Olga I. Ivashkina, Marina A. Zots, Konstantin V. Anokhin, Ekaterina Rostova, Andrei B. Fedotov, and Aleksei M. Zheltikov
Opt. Lett. 34(21) 3373-3375 (2009)

Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

Nathan R. Gemmell, Aongus McCarthy, Baochang Liu, Michael G. Tanner, Sander D. Dorenbos, Valery Zwiller, Michael S. Patterson, Gerald S. Buller, Brian C. Wilson, and Robert H. Hadfield
Opt. Express 21(4) 5005-5013 (2013)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (13)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription