Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.
© 2009 Optical Society of AmericaFull Article | PDF Article
Jun Qian, Xin Li, Ming Wei, Xiangwei Gao, Zhengping Xu, and Sailing He
Opt. Express 16(24) 19568-19578 (2008)
Lyubov V. Doronina, Il'ya V. Fedotov, Aleksandr A. Voronin, Olga I. Ivashkina, Marina A. Zots, Konstantin V. Anokhin, Ekaterina Rostova, Andrei B. Fedotov, and Aleksei M. Zheltikov
Opt. Lett. 34(21) 3373-3375 (2009)
Nathan R. Gemmell, Aongus McCarthy, Baochang Liu, Michael G. Tanner, Sander D. Dorenbos, Valery Zwiller, Michael S. Patterson, Gerald S. Buller, Brian C. Wilson, and Robert H. Hadfield
Opt. Express 21(4) 5005-5013 (2013)