Abstract

We propose an ultracompact parallel label-free biosensor based on concentric silicon-on-insulator microring resonators. Our numerical studies show that the proposed biosensor offers higher sensitivity and a larger detection area than conventional single-ring-based sensors. We analyze the detection sensitivity of the DNA hybridization by immobilizing the probe on top of the double concentric ring resonators and in the ring–ring air gap. For a concentric double-ring system with an area of 27.646μm2, the bulk detection sensitivity is 683nm RIU1. The sensitive uniformity of the system related to the optical field distribution is also studied.

© 2009 Optical Society of America

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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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2008 (4)

2007 (3)

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

O. Lazcka, F. J. Del Campo, and F. X. Munoz, “Pathogen detection: a perspective of traditional methods and biosensors,” Biosens. Bioelectron. 22, 1205-1217 (2007).
[CrossRef]

K. D. Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, “Silicon-on-insulator microring resonator for sensitive and label-free biosensing,” Opt. Express 15, 7610-7615 (2007).
[CrossRef] [PubMed]

2006 (1)

2005 (1)

2004 (2)

A. Ksendzov, M. L. Homer, and A. M. Manfreda, “Integrated optics ring-resonator chemical sensor with polymer transduction layer,” Electron. Lett. 40, 63-65 (2004).
[CrossRef]

S. Elhadj, G. Singh, and R. F. Saraf, “Optical properties of an immobilized DNA monolayer from 255 to 700 nm,” Langmuir 20, 5539-5543 (2004).
[CrossRef]

1999 (1)

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

1997 (1)

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Baets, R.

Bartolozzi, I.

Beumer, T. A. M.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Bienstman, P.

Chu, S. T.

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Dainese, M.

Debackere, P. P. P.

Del Campo, F. J.

O. Lazcka, F. J. Del Campo, and F. X. Munoz, “Pathogen detection: a perspective of traditional methods and biosensors,” Biosens. Bioelectron. 22, 1205-1217 (2007).
[CrossRef]

Elhadj, S.

S. Elhadj, G. Singh, and R. F. Saraf, “Optical properties of an immobilized DNA monolayer from 255 to 700 nm,” Langmuir 20, 5539-5543 (2004).
[CrossRef]

Erickson, D.

Fan, S.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

Foresi, J.

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Greve, J.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Guo, X.

Haus, H. A.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Heideman, R. G.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Homer, M. L.

A. Ksendzov, M. L. Homer, and A. M. Manfreda, “Integrated optics ring-resonator chemical sensor with polymer transduction layer,” Electron. Lett. 40, 63-65 (2004).
[CrossRef]

Joannopoulos, J. D.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

Kanger, J. S.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Khan, M. J.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

Ksendzov , A.

Ksendzov, A.

A. Ksendzov, M. L. Homer, and A. M. Manfreda, “Integrated optics ring-resonator chemical sensor with polymer transduction layer,” Electron. Lett. 40, 63-65 (2004).
[CrossRef]

Laine, J. P.

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Lambeck, P. V.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Lazcka, O.

O. Lazcka, F. J. Del Campo, and F. X. Munoz, “Pathogen detection: a perspective of traditional methods and biosensors,” Biosens. Bioelectron. 22, 1205-1217 (2007).
[CrossRef]

Li, Q.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

Li, X.

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

Li, Y.

Lin, Y.

Little, B. E.

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Mandal, S.

Manfreda, A. M.

A. Ksendzov, M. L. Homer, and A. M. Manfreda, “Integrated optics ring-resonator chemical sensor with polymer transduction layer,” Electron. Lett. 40, 63-65 (2004).
[CrossRef]

Manolatou, C.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

Munoz, F. X.

O. Lazcka, F. J. Del Campo, and F. X. Munoz, “Pathogen detection: a perspective of traditional methods and biosensors,” Biosens. Bioelectron. 22, 1205-1217 (2007).
[CrossRef]

Qiu, M.

Z. Zhang, M. Dainese, L. Wosinski, and M. Qiu, “Resonance-splitting and enhanced notch depth in SOI ring resonators with mutual mode coupling,” Opt. Express 16, 4621-4630(2008).
[CrossRef] [PubMed]

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

Saraf, R. F.

S. Elhadj, G. Singh, and R. F. Saraf, “Optical properties of an immobilized DNA monolayer from 255 to 700 nm,” Langmuir 20, 5539-5543 (2004).
[CrossRef]

Schacht, E.

Scheerlinck, S.

Singh, G.

S. Elhadj, G. Singh, and R. F. Saraf, “Optical properties of an immobilized DNA monolayer from 255 to 700 nm,” Langmuir 20, 5539-5543 (2004).
[CrossRef]

Su, Y.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

Subramaniam, V.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Tong, L.

van Hövell, S. W. F. M.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Villeneuve, P. R.

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

Vos, K. D.

Wijn, R. R.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Wink, T.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Wosinski, L.

Yin, Q.

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

Ymeti, A.

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Zhang, Z.

Z. Zhang, M. Dainese, L. Wosinski, and M. Qiu, “Resonance-splitting and enhanced notch depth in SOI ring resonators with mutual mode coupling,” Opt. Express 16, 4621-4630(2008).
[CrossRef] [PubMed]

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

Biosens. Bioelectron. (1)

O. Lazcka, F. J. Del Campo, and F. X. Munoz, “Pathogen detection: a perspective of traditional methods and biosensors,” Biosens. Bioelectron. 22, 1205-1217 (2007).
[CrossRef]

Electron. Lett. (1)

A. Ksendzov, M. L. Homer, and A. M. Manfreda, “Integrated optics ring-resonator chemical sensor with polymer transduction layer,” Electron. Lett. 40, 63-65 (2004).
[CrossRef]

IEEE J. Quantum Electron. (1)

C. Manolatou, M. J. Khan, S. Fan, P. R. Villeneuve, H. A. Haus, and J. D. Joannopoulos, “Coupling of modes analysis of resonant channel add-drop filters,” IEEE J. Quantum Electron. 35, 1322-1331 (1999).
[CrossRef]

J. Lightwave Technol. (1)

B. E. Little, S. T. Chu, H. A. Haus, J. Foresi, and J. P. Laine, “Microring resonator channel dropping filters,” J. Lightwave Technol. 15, 998-1005 (1997).
[CrossRef]

Langmuir (1)

S. Elhadj, G. Singh, and R. F. Saraf, “Optical properties of an immobilized DNA monolayer from 255 to 700 nm,” Langmuir 20, 5539-5543 (2004).
[CrossRef]

Nano. Lett. (1)

A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. van Hövell, T. A. M. Beumer, R. R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, “Fast, ultrasensitive virus detection using a Young interferometer sensor,” Nano. Lett. 7, 394-397 (2007).
[CrossRef] [PubMed]

Opt. Express (5)

Opt. Lett. (2)

Other (3)

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Concentric silicon micro-ring resonators with enhanced transmission notch depth,” in Proceedings of the Asia- Pacific Optical Communications Conference (APOC) (SPIE, 2008), 7135-25.

X. Li, Z. Zhang, Q. Li, M. Qiu, and Y. Su, “Label-free biosensor based on silicon-on-insulator concentric micro-ring resonators,” in Proceedings of the IEEE Photonics Global Conference (IEEE, 2008).

X. Li, Z. Zhang, Q. Yin, M. Qiu, and Y. Su, “Ultra-compact parallel label-free biosensors based on concentric micro-ring resonators in silicon-on-insulator,” in Proceedings of the Asia Optical Fiber and Optoelectronic 2008 Exposition and Conference (IEEE, 2008).

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Figures (6)

Fig. 1
Fig. 1

Schematic of double concentric ring resonators and a waveguide coupled system.

Fig. 2
Fig. 2

(a) 2D illustration of the multilayer structure. The electrical field profile of the fundamental TE mode propagating through the structure shown in (a) with (b) the ssDNA and (c) the dsDNA on the top layer. (d) Simulation results of transmission spectra before (solid curve) and after (dashed curve) detection in double concentric ring resonators with a 5 μm outer ring radius, 0.5 μm waveguide width, 0.3 μm waveguide–ring air gap, and 0.2 μm ring–ring air gap.

Fig. 3
Fig. 3

Simulation results of transmission spectra before (solid curve) and after (dashed curve) detection by double concentric ring resonators with a 5 μm outer ring radius when the probe is in the air gap.

Fig. 4
Fig. 4

(a) Field distribution of the structure with 0.1 μm ring–ring and 0.1 μm waveguide–ring air gaps at the resonance wavelength of 1559.715 nm . Simulation results of transmission spectra before (solid curve) and after (dashed curve) patch detection on the top locations of the (b) inner and (c) outer ring resonators.

Fig. 5
Fig. 5

(a) Field distribution of the same structure as in Fig. 2d at the resonance wavelength of 1558.239 nm . Simulation results of transmission spectra before (solid curve) and after (dashed curve) patch detection on the top locations of the (b) inner and (c) outer ring resonators.

Fig. 6
Fig. 6

(a) Schematic diagram of the compact parallel biosensor, (b) concentric microring resonators detection unit, (c) illustration of the SOI.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

T ( ω ) = | S o | 2 | S i | 2 = | 1 | k a 2 | [ j ( ω ω b ) + 1 τ b ] [ j ( ω ω a ) + 1 τ a ] [ j ( ω ω b ) + 1 τ b ] + u 2 | 2 ,
u m 2 = ( 1 τ a e 1 τ a i ) 1 τ b = ω 0 2 4 Q b ( 1 Q a e 1 Q a i ) .

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