Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method

Not Accessible

Your library or personal account may give you access

Abstract

We present a two-step reconstruction method that can qualitatively and quantitatively improve the reconstruction of tissue refractive index (RI) distribution by phase-contrast diffuse optical tomography (PCDOT). In this two-step method, we first recover the distribution of tissue absorption and scattering coefficients by conventional diffuse optical tomography to obtain the geometrical information of lesions, allowing the incorporation of geometrical information as a priori in the PCDOT reconstruction using a locally refined mesh. The method is validated by a series of phantom experiments and evaluated using in vivo data from 42 human subjects. The results demonstrate clear contrast of RI between the lesion and the surroundings, making the image interpretation straightforward. The sensitivity and specificity from these 42 cases are both 81% when RI is used as an imaging parameter for distinguishing between malignant and benign lesions.

© 2009 Optical Society of America

Full Article  |  PDF Article
More Like This
Automated data selection method to improve robustness of diffuse optical tomography for breast cancer imaging

Hamed Vavadi and Quing Zhu
Biomed. Opt. Express 7(10) 4007-4020 (2016)

Quantitative reconstruction of refractive index distribution and imaging of glucose concentration by using diffusing light

Xiaoping Liang, Qizhi Zhang, and Huabei Jiang
Appl. Opt. 45(32) 8360-8365 (2006)

Two step imaging reconstruction using truncated pseudoinverse as a preliminary estimate in ultrasound guided diffuse optical tomography

K. M. Shihab Uddin, Atahar Mostafa, Mark Anastasio, and Quing Zhu
Biomed. Opt. Express 8(12) 5437-5449 (2017)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (5)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved