Abstract

Optical spectroscopy can provide useful diagnostic information about the morphological and biochemical changes related to the progression of precancer in epithelial tissue. As precancerous lesions develop, the optical properties of both the superficial epithelium and underlying stroma are altered; measuring spectral data as a function of depth has the potential to improve diagnostic performance. We describe a clinical spectroscopy system with a depth-sensitive, ball lens coupled fiber-optic probe for noninvasive in vivo measurement of oral autofluorescence and diffuse reflectance spectra. We report results of spectroscopic measurements from oral sites in normal volunteers and in patients with neoplastic lesions of the oral mucosa; results indicate that the addition of depth selectivity can enhance the detection of optical changes associated with precancer.

© 2008 Optical Society of America

Full Article  |  PDF Article
Related Articles
Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy

Michael P. Siegel, Young L. Kim, Hemant K. Roy, Ramesh K. Wali, and Vadim Backman
Appl. Opt. 45(2) 335-342 (2006)

In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix

Judith R. Mourant, Tamara M. Powers, Thérese J. Bocklage, Heather M. Greene, Maxine H. Dorin, Alan G. Waxman, Meggan M. Zsemlye, and Harriet O. Smith
Appl. Opt. 48(10) D26-D35 (2009)

Compact beveled fiber optic probe design for enhanced depth discrimination in epithelial tissues

Linda T. Nieman, Marko Jakovljevic, and Konstantin Sokolov
Opt. Express 17(4) 2780-2796 (2009)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription