Abstract

We investigate the use of a digital holographic microscope working with partially coherent spatial illumination to study concentration profiles inside confined deformable bodies flowing in microchannels. The studied phenomenon is rapidly changing in time and requires the recording of the complete holographic information for every frame. For this purpose, we implemented one of the classical methods of off-axis digital holography: the Fourier method. Digital holography allows one to numerically investigate a volume by refocusing the different planes of depth, allowing one to locate the objects under investigation in three dimensions. Furthermore, the phase is directly related to the refractive index, thus to the concentration inside the body. Based on simple symmetry assumptions, we present an original method for determining the concentration profiles inside deformable objects in microconfined flows. Details of the optical and numerical implementation, as well as exemplative experimental results are presented.

© 2008 Optical Society of America

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    [CrossRef]
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    [CrossRef]

2008

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33, 744-746 (2008).
[CrossRef] [PubMed]

N. M. Dragomir and X. M. G. A. Roberts. “Three-dimensional refractive index reconstruction with quantitative phase tomography,” Microsc. Res. Tech. 71, 5-10 (2008).
[CrossRef]

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
[CrossRef]

W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Extended depth of focus in tomographic phase microscopy using a propagation algorithm,” Opt. Lett. 33, 171-173 (2008).
[CrossRef] [PubMed]

D. R. Lide, Handbook of Chemistry and Physics (CRC Press, 2008).

2007

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
[CrossRef]

S. S. Kou and C. J. R. Sheppard, “Imaging in digital holographic microscopy,” Opt. Express 15, 13640-13648 (2007).
[CrossRef] [PubMed]

B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

W. Li, N. C. Loomis, Q. Hu, and C. S. Davis, “Focus detection from digital in-line holograms based on spectral l1 norms,” J. Opt. Soc. Am. A 24, 3054-3062 (2007).
[CrossRef]

C. P. McElhinney, J. B. McDonald, A. Castro, Y. Frauel, B. Javidi, and T. J. Naughton, “Depth-independent segmentation of macroscopic three-dimensional objects encoded in single perspectives of digital holograms,” Opt. Lett. 32, 1229-1231 (2007).
[CrossRef] [PubMed]

L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

2006

T. Colomb, J. Kühn, F. Charrière, C. Depeursinge, P. Marquet, and N. Aspert, “Total aberrations compensation in digital holographic microscopy with a reference conjugated hologram,” Opt. Express 14, 4300-4306 (2006).
[CrossRef] [PubMed]

T.-C.Poon, ed., Digital Holography and Three-Dimensional Display: Principles and Applications (Springer, 2006).
[CrossRef]

F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
[CrossRef] [PubMed]

N. Lue, G. Popescu, T. Ikeda, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Live cell refractometry using microfluidic devices,” Opt. Lett. 31, 2759-2761 (2006).
[CrossRef] [PubMed]

F. Charrière, A. Marian, F. Montfort, J. Kühn, T. Colomb, E. Cuche, P. Marquet, and C. Depeursinge, “Cell refractive index tomography by digital holographic microscopy,” Opt. Lett. 31, 178-180 (2006).
[CrossRef] [PubMed]

F. Dubois, N. Callens, C. Yourassowsky, M. Hoyos, P. Kurowsky, and O. Monnom, “Digital holographic microscopy with reduced spatial coherence for three-dimensional particle flows analysis,” Appl. Opt. 45, 864-871 (2006).
[CrossRef] [PubMed]

G. Indebetouw, Y. Tada, and J. Leacock, “Quantitative phase imaging with scanning holographic microscopy: an experimental assesment,” BioMed. Eng. OnLine 5, 63 (2006).
[CrossRef] [PubMed]

F. Dubois, C. Schockaert, N. Callens, and C. Yourassowsky, “Focus plane detection criteria in digital holography microscopy by amplitude analysis,” Opt. Express 14, 5895-5908 (2006).
[CrossRef] [PubMed]

F. Charrière, N. Pavillon, T. Colomb, T. Heger, E. Mitchell, P. Marquet, B. Rappaz, and C. Depeursinge, “Living specimen tomography by digital holographic microscopy: morphometry of testate amoeba,” Opt. Express 14, 7005-7013 (2006).
[CrossRef] [PubMed]

T. Colomb, F. Montfort, J. Kühn, N. Aspert, E. Cuche, A. Marian, F. Charrière, S. Bourquin, P. Marquet, and C. Depeursinge, “Numerical parametric lens for shifting, magnification and complete aberration compensation in digital holographic microscopy,” J. Opt. Soc. Am. A 23, 3177-3190 (2006).
[CrossRef]

P. Ferraro, D. Alferi, S. D. Nicola, L. D. Petrocellis, A. Finizio, and G. Pierattini, “Quantitative phase-contrast microscopy by a lateral shear approach to digital holographic image reconstruction,” Opt. Lett. 31, 1405-1407 (2006).
[CrossRef] [PubMed]

2005

2004

D. Carl, B. Kemper, G. Wernicke, and G. von Bally, “Parameter-optimized digital holographic microscope for high-resolution living-cell analysis,” Appl. Opt. 43, 6536-6544 (2004).
[CrossRef]

F. Dubois, C. Yourassowsky, and O. Monnom, “Microscopie en holographie digitale avec une source partiellement cohérente,” in Imagerie et Photonique pour les Sciences du Vivant et la Médecine, M. Faupel, P. Smigielski, and R. Grzymala, eds. (Fontis Média & Formatis , 2004), pp. 287-302.

F. Dubois, M.-L. Novella Requena, C. Minetti, O. Monnom, and E. Istasse, “Partial coherence effects in digital holographic microscopy with a laser source,” Appl. Opt. 43, 1131-1139 (2004).
[CrossRef] [PubMed]

V. Vitkova, M. Mader, and T. Podgorski, “Deformation of vesicles flowing through a capillary,” Europhys. Lett. 68, 398-404 (2004).
[CrossRef]

D. Kim and B. Javidi, “Distortion-tolerant 3-D object recognition by using single exposure on-axis digital holography,” Opt. Express 12, 5539-5548 (2004).
[CrossRef] [PubMed]

V. Vitkova, J. Genova, and I. Bivas, “Permeability and the hidden area of lipid bilayers,” Eur. Biophys. J. 33 , 706-714(2004).
[CrossRef] [PubMed]

2003

2002

2000

K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
[CrossRef] [PubMed]

1999

1998

T. Zhang and I. Yamaguchi, “Three-dimensional microscopy with phase-shifting digital holography,” Opt. Lett. 23, 1221-1223 (1998).
[CrossRef]

D. C. Ghiglia and M. D. Pritt, Two-Dimensional Phase Unwrapping. Theory, Algorithms, and Software (Wiley-Interscience1998).

1997

1996

R. Bruinsma, “Rheology and shape transitions of vesicles under capillary flow,” Physica A 234, 249-270 (1996).
[CrossRef]

1995

T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
[CrossRef]

1992

M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
[CrossRef]

1989

D. Mumford and J. Shah, “Optimal approximation by piecewise smooth functions and associated variational problems,” Commun. Pure Appl. Math. 42, 577-685 (1989).
[CrossRef]

1986

1982

1974

F. M. White, Viscous Fluid Flow (McGraw-Hill, 1974).

Alferi, D.

Alfieri, D.

L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

Angelova, M. I.

M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
[CrossRef]

Aspert, N.

Badizadegan, K.

W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Extended depth of focus in tomographic phase microscopy using a propagation algorithm,” Opt. Lett. 33, 171-173 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
[CrossRef]

N. Lue, G. Popescu, T. Ikeda, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Live cell refractometry using microfluidic devices,” Opt. Lett. 31, 2759-2761 (2006).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10, 060503 (2005).
[CrossRef]

Best, C. A.

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10, 060503 (2005).
[CrossRef]

Bevilacqua, F.

Bivas, I.

V. Vitkova, J. Genova, and I. Bivas, “Permeability and the hidden area of lipid bilayers,” Eur. Biophys. J. 33 , 706-714(2004).
[CrossRef] [PubMed]

Bothorel, P.

M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
[CrossRef]

Bourquin, S.

Bredebusch, I.

B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

Bruinsma, R.

J. Nardi, R. Bruinsma, and E. Sackmann, “Vesicles as osmotic motors,” Phys. Rev. Lett. 82, 5168-5171 (1999).
[CrossRef]

R. Bruinsma, “Rheology and shape transitions of vesicles under capillary flow,” Physica A 234, 249-270 (1996).
[CrossRef]

Callens, N.

Carl, D.

Castro, A.

Charrière, F.

Choi, W.

W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Extended depth of focus in tomographic phase microscopy using a propagation algorithm,” Opt. Lett. 33, 171-173 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
[CrossRef]

Colomb, T.

Coppola, G.

Cuche, E.

Dasari, R. R.

Davis, C. S.

De Nicola, S.

L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

P. Ferraro, S. De Nicola, A. Finizio, G. Coppola, S. Grilli, C. Magro, and G. Pierattini, “Compensation of the inherent wave front curvature in digital holographic coherent microscopy for quantitative phase-contrast imaging,” Appl. Opt. 42, 1938-1946 (2003).
[CrossRef] [PubMed]

De Petrocellis, L.

L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

Debailleul, M.

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
[CrossRef]

Debeir, O.

F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
[CrossRef] [PubMed]

Decaestecker, C.

F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
[CrossRef] [PubMed]

Depeursinge, C.

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33, 744-746 (2008).
[CrossRef] [PubMed]

F. Charrière, A. Marian, F. Montfort, J. Kühn, T. Colomb, E. Cuche, P. Marquet, and C. Depeursinge, “Cell refractive index tomography by digital holographic microscopy,” Opt. Lett. 31, 178-180 (2006).
[CrossRef] [PubMed]

T. Colomb, J. Kühn, F. Charrière, C. Depeursinge, P. Marquet, and N. Aspert, “Total aberrations compensation in digital holographic microscopy with a reference conjugated hologram,” Opt. Express 14, 4300-4306 (2006).
[CrossRef] [PubMed]

F. Charrière, N. Pavillon, T. Colomb, T. Heger, E. Mitchell, P. Marquet, B. Rappaz, and C. Depeursinge, “Living specimen tomography by digital holographic microscopy: morphometry of testate amoeba,” Opt. Express 14, 7005-7013 (2006).
[CrossRef] [PubMed]

T. Colomb, F. Montfort, J. Kühn, N. Aspert, E. Cuche, A. Marian, F. Charrière, S. Bourquin, P. Marquet, and C. Depeursinge, “Numerical parametric lens for shifting, magnification and complete aberration compensation in digital holographic microscopy,” J. Opt. Soc. Am. A 23, 3177-3190 (2006).
[CrossRef]

B. Rappaz, P. Marquet, E. Cuche, Y. Emery, C. Depeursinge, and P. J. Magistretti, “Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy,” Opt. Express 13, 9361-9373(2005).
[CrossRef] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30, 468-470 (2005).
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E. Cuche, F. Bevilacqua, and C. Depeursinge, “Digital holography for quantitative phase contrast imaging,” Opt. Lett. 24, 291-293 (1999).
[CrossRef]

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T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
[CrossRef]

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B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

Dragomir, N. M.

N. M. Dragomir and X. M. G. A. Roberts. “Three-dimensional refractive index reconstruction with quantitative phase tomography,” Microsc. Res. Tech. 71, 5-10 (2008).
[CrossRef]

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F. Dubois, N. Callens, C. Yourassowsky, M. Hoyos, P. Kurowsky, and O. Monnom, “Digital holographic microscopy with reduced spatial coherence for three-dimensional particle flows analysis,” Appl. Opt. 45, 864-871 (2006).
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F. Dubois, C. Schockaert, N. Callens, and C. Yourassowsky, “Focus plane detection criteria in digital holography microscopy by amplitude analysis,” Opt. Express 14, 5895-5908 (2006).
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F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
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F. Dubois, M.-L. Novella Requena, C. Minetti, O. Monnom, and E. Istasse, “Partial coherence effects in digital holographic microscopy with a laser source,” Appl. Opt. 43, 1131-1139 (2004).
[CrossRef] [PubMed]

F. Dubois, O. Monnom, C. Yourassowsky, and J.-C. Legros, “Border processing in digital holography by extension of the digital hologram and reduction of the higher spatial frequencies,” Appl. Opt. 41, 2621-2626 (2002).
[CrossRef] [PubMed]

F. Dubois, C. Minetti, O. Monnom, C. Yourassowsky, and J.-C. Legros, “Pattern recognition with digital holographic microscope working in partially coherent illumination,” Appl. Opt. 41, 4108-4119 (2002).
[CrossRef] [PubMed]

F. Dubois, L. Joannes, and J.-C. Legros, “Improved three-dimensional imaging with digital holography microscope using a partial spatial coherent source,” Appl. Opt. 38, 7085-7094 (1999).
[CrossRef]

Emery, Y.

Evans, E.

K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
[CrossRef] [PubMed]

Fang-Yen, C.

W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Extended depth of focus in tomographic phase microscopy using a propagation algorithm,” Opt. Lett. 33, 171-173 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
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M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
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Ferraro, P.

Finizio, A.

Frauel, Y.

Genova, J.

V. Vitkova, J. Genova, and I. Bivas, “Permeability and the hidden area of lipid bilayers,” Eur. Biophys. J. 33 , 706-714(2004).
[CrossRef] [PubMed]

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M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
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D. C. Ghiglia and M. D. Pritt, Two-Dimensional Phase Unwrapping. Theory, Algorithms, and Software (Wiley-Interscience1998).

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H. Noguchi and G. Gompper, “Shape transitions of fluid vesicles and red blood cells in capillary flows,” Proc. Natl. Acad. Sci. USA 102, 14159-14164 (2005).
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L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

P. Ferraro, S. De Nicola, A. Finizio, G. Coppola, S. Grilli, C. Magro, and G. Pierattini, “Compensation of the inherent wave front curvature in digital holographic coherent microscopy for quantitative phase-contrast imaging,” Appl. Opt. 42, 1938-1946 (2003).
[CrossRef] [PubMed]

Gustafsson, M.

Haeberlé, O.

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
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G. Indebetouw, Y. Tada, and J. Leacock, “Quantitative phase imaging with scanning holographic microscopy: an experimental assesment,” BioMed. Eng. OnLine 5, 63 (2006).
[CrossRef] [PubMed]

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Javidi, B.

Joannes, L.

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B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

D. Carl, B. Kemper, G. Wernicke, and G. von Bally, “Parameter-optimized digital holographic microscope for high-resolution living-cell analysis,” Appl. Opt. 43, 6536-6544 (2004).
[CrossRef]

Kim, D.

Kim, T.

Kiss, R.

F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
[CrossRef] [PubMed]

Kobayashi, S.

Kosmeier, S.

B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

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Kreis, T.

Kühn, J.

Kurowsky, P.

Langehanenberg, P.

B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

Lauer, V.

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
[CrossRef]

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G. Indebetouw, Y. Tada, and J. Leacock, “Quantitative phase imaging with scanning holographic microscopy: an experimental assesment,” BioMed. Eng. OnLine 5, 63 (2006).
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W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
[CrossRef]

N. Lue, G. Popescu, T. Ikeda, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Live cell refractometry using microfluidic devices,” Opt. Lett. 31, 2759-2761 (2006).
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V. Vitkova, M. Mader, and T. Podgorski, “Deformation of vesicles flowing through a capillary,” Europhys. Lett. 68, 398-404 (2004).
[CrossRef]

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Magro, C.

Marian, A.

Marquet, P.

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33, 744-746 (2008).
[CrossRef] [PubMed]

F. Charrière, A. Marian, F. Montfort, J. Kühn, T. Colomb, E. Cuche, P. Marquet, and C. Depeursinge, “Cell refractive index tomography by digital holographic microscopy,” Opt. Lett. 31, 178-180 (2006).
[CrossRef] [PubMed]

T. Colomb, J. Kühn, F. Charrière, C. Depeursinge, P. Marquet, and N. Aspert, “Total aberrations compensation in digital holographic microscopy with a reference conjugated hologram,” Opt. Express 14, 4300-4306 (2006).
[CrossRef] [PubMed]

T. Colomb, F. Montfort, J. Kühn, N. Aspert, E. Cuche, A. Marian, F. Charrière, S. Bourquin, P. Marquet, and C. Depeursinge, “Numerical parametric lens for shifting, magnification and complete aberration compensation in digital holographic microscopy,” J. Opt. Soc. Am. A 23, 3177-3190 (2006).
[CrossRef]

F. Charrière, N. Pavillon, T. Colomb, T. Heger, E. Mitchell, P. Marquet, B. Rappaz, and C. Depeursinge, “Living specimen tomography by digital holographic microscopy: morphometry of testate amoeba,” Opt. Express 14, 7005-7013 (2006).
[CrossRef] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30, 468-470 (2005).
[CrossRef] [PubMed]

B. Rappaz, P. Marquet, E. Cuche, Y. Emery, C. Depeursinge, and P. J. Magistretti, “Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy,” Opt. Express 13, 9361-9373(2005).
[CrossRef] [PubMed]

McDonald, J. B.

McElhinney, C. P.

Meleard, P.

M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
[CrossRef]

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L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
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Mitchell, E.

Monnom, O.

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D. Mumford and J. Shah, “Optimal approximation by piecewise smooth functions and associated variational problems,” Commun. Pure Appl. Math. 42, 577-685 (1989).
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K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
[CrossRef] [PubMed]

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Noguchi, H.

H. Noguchi and G. Gompper, “Shape transitions of fluid vesicles and red blood cells in capillary flows,” Proc. Natl. Acad. Sci. USA 102, 14159-14164 (2005).
[CrossRef] [PubMed]

Oh, S.

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Meth. 4, 717-719 (2007).
[CrossRef]

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K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
[CrossRef] [PubMed]

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Petrocellis, L. D.

Pierattini, G.

Podgorski, T.

V. Vitkova, M. Mader, and T. Podgorski, “Deformation of vesicles flowing through a capillary,” Europhys. Lett. 68, 398-404 (2004).
[CrossRef]

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T.-C. Poon and T. Kim, “Optical image recognition of three-dimensional objects,” Appl. Opt. 38, 370-381 (1999).
[CrossRef]

T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
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Pritt, M. D.

D. C. Ghiglia and M. D. Pritt, Two-Dimensional Phase Unwrapping. Theory, Algorithms, and Software (Wiley-Interscience1998).

Rappaz, B.

Rawicz, W.

K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
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N. M. Dragomir and X. M. G. A. Roberts. “Three-dimensional refractive index reconstruction with quantitative phase tomography,” Microsc. Res. Tech. 71, 5-10 (2008).
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J. Nardi, R. Bruinsma, and E. Sackmann, “Vesicles as osmotic motors,” Phys. Rev. Lett. 82, 5168-5171 (1999).
[CrossRef]

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T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
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B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
[CrossRef] [PubMed]

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D. Mumford and J. Shah, “Optimal approximation by piecewise smooth functions and associated variational problems,” Commun. Pure Appl. Math. 42, 577-685 (1989).
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Shinoda, K.

T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
[CrossRef]

Simon, B.

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
[CrossRef]

Soleau, S.

M. I. Angelova, S. Soleau, P. Meleard, J.-F. Faucon, and P. Bothorel, “Preparation of giant vesicles by external ac electric fields. Kinetics and applications,” Prog. Colloid Polym. Sci. 89, 127 (1992).
[CrossRef]

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T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
[CrossRef]

Tada, Y.

G. Indebetouw, Y. Tada, and J. Leacock, “Quantitative phase imaging with scanning holographic microscopy: an experimental assesment,” BioMed. Eng. OnLine 5, 63 (2006).
[CrossRef] [PubMed]

Takeda, M.

Van Ham, P.

F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
[CrossRef] [PubMed]

Vitkova, V.

V. Vitkova, M. Mader, and T. Podgorski, “Deformation of vesicles flowing through a capillary,” Europhys. Lett. 68, 398-404 (2004).
[CrossRef]

V. Vitkova, J. Genova, and I. Bivas, “Permeability and the hidden area of lipid bilayers,” Eur. Biophys. J. 33 , 706-714(2004).
[CrossRef] [PubMed]

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B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
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D. Carl, B. Kemper, G. Wernicke, and G. von Bally, “Parameter-optimized digital holographic microscope for high-resolution living-cell analysis,” Appl. Opt. 43, 6536-6544 (2004).
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T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
[CrossRef]

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Yourassowsky, C.

Zhang, T.

Appl. Opt.

F. Dubois, L. Joannes, and J.-C. Legros, “Improved three-dimensional imaging with digital holography microscope using a partial spatial coherent source,” Appl. Opt. 38, 7085-7094 (1999).
[CrossRef]

D. Carl, B. Kemper, G. Wernicke, and G. von Bally, “Parameter-optimized digital holographic microscope for high-resolution living-cell analysis,” Appl. Opt. 43, 6536-6544 (2004).
[CrossRef]

P. Ferraro, S. De Nicola, A. Finizio, G. Coppola, S. Grilli, C. Magro, and G. Pierattini, “Compensation of the inherent wave front curvature in digital holographic coherent microscopy for quantitative phase-contrast imaging,” Appl. Opt. 42, 1938-1946 (2003).
[CrossRef] [PubMed]

T.-C. Poon and T. Kim, “Optical image recognition of three-dimensional objects,” Appl. Opt. 38, 370-381 (1999).
[CrossRef]

F. Dubois, C. Minetti, O. Monnom, C. Yourassowsky, and J.-C. Legros, “Pattern recognition with digital holographic microscope working in partially coherent illumination,” Appl. Opt. 41, 4108-4119 (2002).
[CrossRef] [PubMed]

F. Dubois, O. Monnom, C. Yourassowsky, and J.-C. Legros, “Border processing in digital holography by extension of the digital hologram and reduction of the higher spatial frequencies,” Appl. Opt. 41, 2621-2626 (2002).
[CrossRef] [PubMed]

F. Dubois, N. Callens, C. Yourassowsky, M. Hoyos, P. Kurowsky, and O. Monnom, “Digital holographic microscopy with reduced spatial coherence for three-dimensional particle flows analysis,” Appl. Opt. 45, 864-871 (2006).
[CrossRef] [PubMed]

F. Dubois, M.-L. Novella Requena, C. Minetti, O. Monnom, and E. Istasse, “Partial coherence effects in digital holographic microscopy with a laser source,” Appl. Opt. 43, 1131-1139 (2004).
[CrossRef] [PubMed]

Appl. Phys. Lett.

L. Miccio, D. Alfieri, S. Grilli, P. Ferraro, A. Finizio, L. De Petrocellis, and S. De Nicola, “Direct full compensation of the aberrations in quantitative phase microscopy of thin objects by a single digital hologram,” Appl. Phys. Lett. 90, 041104 (2007).
[CrossRef]

BioMed. Eng. OnLine

G. Indebetouw, Y. Tada, and J. Leacock, “Quantitative phase imaging with scanning holographic microscopy: an experimental assesment,” BioMed. Eng. OnLine 5, 63 (2006).
[CrossRef] [PubMed]

Biophys. J.

K. Olbrich, W. Rawicz, D. Needham, and E. Evans, “Water permeability and mechanical strength of polyunsaturated lipid bilayers,” Biophys. J. 79, 321-327 (2000).
[CrossRef] [PubMed]

Commun. Pure Appl. Math.

D. Mumford and J. Shah, “Optimal approximation by piecewise smooth functions and associated variational problems,” Commun. Pure Appl. Math. 42, 577-685 (1989).
[CrossRef]

Eur. Biophys. J.

V. Vitkova, J. Genova, and I. Bivas, “Permeability and the hidden area of lipid bilayers,” Eur. Biophys. J. 33 , 706-714(2004).
[CrossRef] [PubMed]

Europhys. Lett.

V. Vitkova, M. Mader, and T. Podgorski, “Deformation of vesicles flowing through a capillary,” Europhys. Lett. 68, 398-404 (2004).
[CrossRef]

J Biomed. Opt.

B. Kemper, S. Kosmeier, P. Langehanenberg, G. von Bally, I. Bredebusch, W. Domschke, and J. Schnekenburger, “Integral refractive index determination of living suspension cells by multifocus digital holographic phase contrast microscopy,” J Biomed. Opt. 12, 054009 (2007).
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J. Biomed. Opt.

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10, 060503 (2005).
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F. Dubois, C. Yourassowsky, O. Monnom, J.-C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11, 054032 (2006).
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J. Opt. Soc. Am.

J. Opt. Soc. Am. A

Meas. Sci. Technol.

M. Debailleul, B. Simon, V. Georges, O. Haeberlé, and V. Lauer, “Holographic microscopy and diffractive microtomography of transparent samples,” Meas. Sci. Technol. 19, 074009 (8 pages) (2008).
[CrossRef]

Microsc. Res. Tech.

N. M. Dragomir and X. M. G. A. Roberts. “Three-dimensional refractive index reconstruction with quantitative phase tomography,” Microsc. Res. Tech. 71, 5-10 (2008).
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Opt. Eng.

T.-C. Poon, K. Doh, B. Schilling, M. Wu, K. Shinoda, and Y. Suzuki, “Three-dimensional microscopy by optical scanning holography,” Opt. Eng. 34, pp. 1338-1344 (1995).
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Opt. Express

Opt. Lett.

P. Ferraro, D. Alferi, S. D. Nicola, L. D. Petrocellis, A. Finizio, and G. Pierattini, “Quantitative phase-contrast microscopy by a lateral shear approach to digital holographic image reconstruction,” Opt. Lett. 31, 1405-1407 (2006).
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W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Extended depth of focus in tomographic phase microscopy using a propagation algorithm,” Opt. Lett. 33, 171-173 (2008).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33, 744-746 (2008).
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C. P. McElhinney, J. B. McDonald, A. Castro, Y. Frauel, B. Javidi, and T. J. Naughton, “Depth-independent segmentation of macroscopic three-dimensional objects encoded in single perspectives of digital holograms,” Opt. Lett. 32, 1229-1231 (2007).
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Figures (5)

Fig. 1
Fig. 1

Optical setup of the digital holographic microscope. L1, focusing lens; RGG, rotating ground glass for spatial coherence reduction; L2, collimating lens; L3, L4, identical microscope lenses ( × 20 ) ; L5, refocusing lens; CCD, charge-coupled device camera; M1–M3, mirrors; BS1, BS2, beam splitters.

Fig. 2
Fig. 2

(a) Intensity image of a vesicle in a microchannel of 80 μm width. The vesicle is at a distance of 19 μm from the DHM focus plan. (b) Phase image of a vesicle in a microchannel. The phase values are remapped to 256 gray levels. (c) Compensated phase map of Fig. 2b. The phase values are remapped to 256 gray levels.

Fig. 3
Fig. 3

Half optical width e ( x 0 , y ) / 2 along two cross sections located at two different positions x 0 along the longitudinal axis of vesicle 1. Inset, location of these cross sections on the compensated phase image of the vesicle. Solid curves show the fits with a half-ellipse.

Fig. 4
Fig. 4

Evolution of the index Δ n ( x ) along the longitudinal axis of the vesicle for three different vesicle velocities (average over ten measurements for each velocity, to get rid of the local inhomogeneities of the channel: for clarity, only one typical error bar is shown on each curve). x = 0 corresponds to the rear of the vesicle, which is moving from left to right. The right-hand part of the figure shows the corresponding shapes given by the compensated phase image.

Fig. 5
Fig. 5

Index gradient inside vesicle 2 doing a U-turn. The time step between two curves is 1 / 24 s . During the 1 / 12 s corresponding to the three curves shown, the vesicle has just reversed its fore-aft shape but has only moved a few micrometers. Nevertheless, the gradient inversion is clear. Note that each curve corresponds to a single frame, and is thus noisier than the curves of Fig. 4.

Tables (1)

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Table 1 Characteristics of the Vesicles Presented for Demonstration

Equations (8)

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U ( x , y ) = A ( x , y ) exp [ i φ ( x , y ) ] .
exp [ i φ ( s , y ) ] = exp [ i β ( x , y ) ] exp [ i ϕ ( x , y ) ] ,
β ( x , y ) = σ x ( x x 0 ) 2 + σ y ( y y 0 ) 2 ,
ψ ( σ , x 0 , y 0 ) = x = 1 N y = 1 N | [ δ δ x ( exp { i φ ( x , y ) } exp { i [ σ x ( x x 0 ) 2 + σ y ( y y 0 ) 2 ] } ) ] | 2 + | [ δ δ y ( exp { i φ ( x , y ) } exp { i [ σ x ( x x 0 ) 2 + σ y ( y y 0 ) 2 ] } ) ] | 2 ,
ϕ ( x , y ) = φ ( x , y ) β ( x , y ) if   φ ( x , y ) > β ( x , y ) , ϕ ( x , y ) = 2 π φ ( x , y ) + β ( x , y ) if   φ ( x , y ) < β ( x , y ) ,
e ( x , y ) = Φ ( x , y ) λ 2 π ,
e ( x , y ) = 2 h ( x , y ) Δ n ( x , y ) .
e ( x i , y ) / 2 = α ( x i ) [ R ( x i ) 2 y 2 ] 1 / 2 .

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