Fourier-domain digital holographic optical coherence imaging of living tissue

Abstract

Digital holographic optical coherence imaging is a full-frame coherence-gated imaging approach that uses a CCD camera to record and reconstruct digital holograms from living tissue. Recording digital holograms at the optical Fourier plane has advantages for diffuse targets compared with Fresnel off-axis digital holography. A digital hologram captured at the Fourier plane requires only a 2D fast Fourier transform for numerical reconstruction. We have applied this technique for the depth-resolved imaging of rat osteogenic tumor multicellular spheroids and acquired cross-section images of the anterior segment and the retinal region of a mouse eye. A penetration depth of $1.4\text{\hspace{0.17em} mm}$ for the tumor spheroids was achieved.

© 2007 Optical Society of America

Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye

Kwan Jeong, Leilei Peng, John J. Turek, Michael R. Melloch, and David D. Nolte
Appl. Opt. 44(10) 1798-1805 (2005)

Holographic optical coherence imaging of rat osteogenic sarcoma tumor spheroids

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Opt. Express 17(14) 11834-11849 (2009)

Time-dependent speckle in holographic optical coherence imaging and the health of tumor tissue

P. Yu, L. Peng, M. Mustata, J. J. Turek, M. R. Melloch, and D. D. Nolte
Opt. Lett. 29(1) 68-70 (2004)