Abstract

What we believe to be a new label-free multichannel biosensing platform is proposed. It is composed of surface-immobilized gold nanospheres (SIGNs) above a gold surface with a nanogap supported by a merocyanine self-assembled monolayer. The circular SIGN spots with a diameter of 120μm were arrayed for multichannel biosensing on a glass slide. Two kinds of sensing methods were examined: One is a reflectivity measurement of a blue ray and the other is a second-harmonic generation measurement. It was found that the SIGN system can be used as a promising platform for multichannel biosensing in both sensing methods.

© 2007 Optical Society of America

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2006 (6)

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

H. Huang and Y. Chen, "Label-free reading of microarray-based proteins with high throughput surface plasmon resonance imaging," Biosens. Bioelectron. 22, 644-648 (2006).
[CrossRef] [PubMed]

K. Tsuboi and K. Kajikawa, "Arrays of microdots of gold nanoparticles immobilized above gold surface probed by optical second-harmonic microscopy," Appl. Phys. Lett. 88, 103102 (2006).
[CrossRef]

S. Abe and K. Kajikawa, "Linear and nonlinear optical properties of gold nanoparticles immobilized on metallic surface," Phys. Rev. B 74, 035416 (2006).
[CrossRef]

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

2005 (4)

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

M. Piliarik, H. Vaisocheiova, and J. Homola, "A new surface plasmon resonance sensor for high-throughput screening applications," Biosens. Bioelectron. 20, 2104-2110 (2005).
[CrossRef] [PubMed]

2004 (1)

K. Mitsui, Y. Handa, and K. Kajikawa, "Optical fiber affinity biosensor based on localized surface plasmon resonance," Appl. Phys. Lett. 85, 4231-4233 (2004).
[CrossRef]

2003 (5)

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

T. Okamoto and I. Yamaguchi, "Optical absorption study of the surface plasmon resonance in gold nanoparticles immobilized onto a gold substrate by a self-assembly technique," J. Phys. Chem. 107, 10321-10324 (2003).
[CrossRef]

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

M. Watanabe and K. Kajikawa, "An optical fiber biosensor based on anonymous reflection of gold," Sens. Actuators B 86, 126-130 (2003).
[CrossRef]

2002 (1)

A. J. Haes and R. P. Van Duyne, "A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles," J. Am. Chem. Soc. 124, 10596-10604 (2002).
[CrossRef] [PubMed]

2001 (1)

2000 (3)

T. Okamoto, I. Yamaguchi, and T. Kobayashi, "Local plasmon sensor with gold colloid monolayers deposited upon glass substrates," Opt. Lett. 25, 372-374 (2000).
[CrossRef]

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

J. M. Brockman, B. P. Nelson, and R. M. Corn, "Surface plasmon resonance imaging measurements of ultrathin organic films," Annu. Rev. Phys. Chem. 51, 41-63 (2000).
[CrossRef] [PubMed]

1999 (2)

J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
[CrossRef]

M. Himmelhaus and H. Takei, "Cap shaped gold nanoparticles for an optical biosensor," Sens. Actuators B 63, 24-30 (1999).
[CrossRef]

1998 (1)

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

1994 (1)

Y. R. Shen, "Nonlinear optical studies of surfaces," Appl. Phys. A 58, 541-543 (1994).
[CrossRef]

Abe, S.

S. Abe and K. Kajikawa, "Linear and nonlinear optical properties of gold nanoparticles immobilized on metallic surface," Phys. Rev. B 74, 035416 (2006).
[CrossRef]

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

Bassil, N.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Bidan, G.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Brockman, J. M.

J. M. Brockman, B. P. Nelson, and R. M. Corn, "Surface plasmon resonance imaging measurements of ultrathin organic films," Annu. Rev. Phys. Chem. 51, 41-63 (2000).
[CrossRef] [PubMed]

Canva, M.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Chen, Y.

H. Huang and Y. Chen, "Label-free reading of microarray-based proteins with high throughput surface plasmon resonance imaging," Biosens. Bioelectron. 22, 644-648 (2006).
[CrossRef] [PubMed]

Corn, R. M.

J. M. Brockman, B. P. Nelson, and R. M. Corn, "Surface plasmon resonance imaging measurements of ultrathin organic films," Annu. Rev. Phys. Chem. 51, 41-63 (2000).
[CrossRef] [PubMed]

Courtois, V.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Dingxin, W.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Dongsheng, W.

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Fujita, K.

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Fukuba, S.

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

Furuya, K.

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
[CrossRef]

Goossens, M.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Guedon, P.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Ha, K.-S.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Haes, A. J.

A. J. Haes and R. P. Van Duyne, "A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles," J. Am. Chem. Soc. 124, 10596-10604 (2002).
[CrossRef] [PubMed]

Han, J.-A.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Handa, Y.

K. Mitsui, Y. Handa, and K. Kajikawa, "Optical fiber affinity biosensor based on localized surface plasmon resonance," Appl. Phys. Lett. 85, 4231-4233 (2004).
[CrossRef]

Hara, M.

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Himmelhaus, M.

M. Himmelhaus and H. Takei, "Cap shaped gold nanoparticles for an optical biosensor," Sens. Actuators B 63, 24-30 (1999).
[CrossRef]

Homola, J.

M. Piliarik, H. Vaisocheiova, and J. Homola, "A new surface plasmon resonance sensor for high-throughput screening applications," Biosens. Bioelectron. 20, 2104-2110 (2005).
[CrossRef] [PubMed]

J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
[CrossRef]

Hua, O. J.

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Huang, H.

H. Huang and Y. Chen, "Label-free reading of microarray-based proteins with high throughput surface plasmon resonance imaging," Biosens. Bioelectron. 22, 644-648 (2006).
[CrossRef] [PubMed]

Jung, J.-W.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Jung, S.-H.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Kajikawa, K.

K. Tsuboi and K. Kajikawa, "Arrays of microdots of gold nanoparticles immobilized above gold surface probed by optical second-harmonic microscopy," Appl. Phys. Lett. 88, 103102 (2006).
[CrossRef]

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

S. Abe and K. Kajikawa, "Linear and nonlinear optical properties of gold nanoparticles immobilized on metallic surface," Phys. Rev. B 74, 035416 (2006).
[CrossRef]

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

K. Mitsui, Y. Handa, and K. Kajikawa, "Optical fiber affinity biosensor based on localized surface plasmon resonance," Appl. Phys. Lett. 85, 4231-4233 (2004).
[CrossRef]

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

M. Watanabe and K. Kajikawa, "An optical fiber biosensor based on anonymous reflection of gold," Sens. Actuators B 86, 126-130 (2003).
[CrossRef]

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Kim, H.-S.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Kim, W. J.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Kim, Y.-M.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Knoll, W.

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Kobayashi, T.

Lecaruyer, P.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Lee, S.-J.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Lesbre, F.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Levy, Y.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Livache, T.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Maillart, E.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Manera, M. G.

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Mannelli, I.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Martin, F.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Mihara, H.

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

Millot, M. C.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Millot, M.-C.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Mitsui, K.

K. Mitsui, Y. Handa, and K. Kajikawa, "Optical fiber affinity biosensor based on localized surface plasmon resonance," Appl. Phys. Lett. 85, 4231-4233 (2004).
[CrossRef]

Narwa, R.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Nelson, B. P.

J. M. Brockman, B. P. Nelson, and R. M. Corn, "Surface plasmon resonance imaging measurements of ultrathin organic films," Annu. Rev. Phys. Chem. 51, 41-63 (2000).
[CrossRef] [PubMed]

Okamoto, T.

T. Okamoto and I. Yamaguchi, "Optical absorption study of the surface plasmon resonance in gold nanoparticles immobilized onto a gold substrate by a self-assembly technique," J. Phys. Chem. 107, 10321-10324 (2003).
[CrossRef]

T. Okamoto, I. Yamaguchi, and T. Kobayashi, "Local plasmon sensor with gold colloid monolayers deposited upon glass substrates," Opt. Lett. 25, 372-374 (2000).
[CrossRef]

Ouchi, Y.

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Piliarik, M.

M. Piliarik, H. Vaisocheiova, and J. Homola, "A new surface plasmon resonance sensor for high-throughput screening applications," Biosens. Bioelectron. 20, 2104-2110 (2005).
[CrossRef] [PubMed]

Pissard, S.

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

Quaranta, F.

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Rella, R.

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Roger, G.

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Roget, A.

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Sasabe, H.

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Seki, K.

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Shen, Y. R.

Y. R. Shen, "Nonlinear optical studies of surfaces," Appl. Phys. A 58, 541-543 (1994).
[CrossRef]

Shimojo, M.

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

Siciliano, P.

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Simpson, G. J.

Spadavecchia, J.

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

Takei, H.

M. Himmelhaus and H. Takei, "Cap shaped gold nanoparticles for an optical biosensor," Sens. Actuators B 63, 24-30 (1999).
[CrossRef]

Tanaka, M.

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

Tomizaki, K.-Y.

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

Tsuboi, K.

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

K. Tsuboi and K. Kajikawa, "Arrays of microdots of gold nanoparticles immobilized above gold surface probed by optical second-harmonic microscopy," Appl. Phys. Lett. 88, 103102 (2006).
[CrossRef]

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Usui, K.

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

Vaisocheiova, H.

M. Piliarik, H. Vaisocheiova, and J. Homola, "A new surface plasmon resonance sensor for high-throughput screening applications," Biosens. Bioelectron. 20, 2104-2110 (2005).
[CrossRef] [PubMed]

Van Duyne, R. P.

A. J. Haes and R. P. Van Duyne, "A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles," J. Am. Chem. Soc. 124, 10596-10604 (2002).
[CrossRef] [PubMed]

Watanabe, M.

M. Watanabe and K. Kajikawa, "An optical fiber biosensor based on anonymous reflection of gold," Sens. Actuators B 86, 126-130 (2003).
[CrossRef]

Watanabe, S.

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

Wei, L.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Xiang, D.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Xing, W.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Xinglong, Y.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Xinsheng, Z.

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Yamaguchi, I.

T. Okamoto and I. Yamaguchi, "Optical absorption study of the surface plasmon resonance in gold nanoparticles immobilized onto a gold substrate by a self-assembly technique," J. Phys. Chem. 107, 10321-10324 (2003).
[CrossRef]

T. Okamoto, I. Yamaguchi, and T. Kobayashi, "Local plasmon sensor with gold colloid monolayers deposited upon glass substrates," Opt. Lett. 25, 372-374 (2000).
[CrossRef]

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
[CrossRef]

Yonggui, D.

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Yuk, J. S.

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

Zibo, Y.

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

Anal. Chem. (1)

P. Guedon, T. Livache, F. Martin, F. Lesbre, A. Roget, G. Bidan, and Y. Levy, "Characterization and optimization of a real-time, parallel, label-free polypyrrole-based DNA sensor by surface plasmon resonance imaging," Anal. Chem. 72, 6003-6009 (2000).
[CrossRef]

Annu. Rev. Phys. Chem. (1)

J. M. Brockman, B. P. Nelson, and R. M. Corn, "Surface plasmon resonance imaging measurements of ultrathin organic films," Annu. Rev. Phys. Chem. 51, 41-63 (2000).
[CrossRef] [PubMed]

Appl. Phys. A (1)

Y. R. Shen, "Nonlinear optical studies of surfaces," Appl. Phys. A 58, 541-543 (1994).
[CrossRef]

Appl. Phys. Lett. (2)

K. Tsuboi and K. Kajikawa, "Arrays of microdots of gold nanoparticles immobilized above gold surface probed by optical second-harmonic microscopy," Appl. Phys. Lett. 88, 103102 (2006).
[CrossRef]

K. Mitsui, Y. Handa, and K. Kajikawa, "Optical fiber affinity biosensor based on localized surface plasmon resonance," Appl. Phys. Lett. 85, 4231-4233 (2004).
[CrossRef]

Appl. Spectrosc. (1)

Biosens. Bioelectron. (4)

J. S. Yuk, H.-S. Kim, J.-W. Jung, S.-H. Jung, S.-J. Lee, W. J. Kim, J.-A. Han, Y.-M. Kim, and K.-S. Ha, "Analysis of protein interactions on protein arrays by a novel surface plasmon resonance imaging," Biosens. Bioelectron. 21, 1521-1528 (2006).
[CrossRef]

H. Huang and Y. Chen, "Label-free reading of microarray-based proteins with high throughput surface plasmon resonance imaging," Biosens. Bioelectron. 22, 644-648 (2006).
[CrossRef] [PubMed]

M. Piliarik, H. Vaisocheiova, and J. Homola, "A new surface plasmon resonance sensor for high-throughput screening applications," Biosens. Bioelectron. 20, 2104-2110 (2005).
[CrossRef] [PubMed]

J. Spadavecchia, M. G. Manera, F. Quaranta, P. Siciliano, and R. Rella, "Surface plasmon resonance imaging of DNA based biosensors for potential applications in food analysis," Biosens. Bioelectron. 21, 894-900 (2005).
[CrossRef] [PubMed]

J. Am. Chem. Soc. (1)

A. J. Haes and R. P. Van Duyne, "A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles," J. Am. Chem. Soc. 124, 10596-10604 (2002).
[CrossRef] [PubMed]

J. Chem. Phys. (1)

K. Tsuboi, S. Abe, S. Fukuba, M. Shimojo, M. Tanaka, K. Furuya, and K. Kajikawa, "A considerable enhancement of second harmonic generation from surface immobilized gold nanospheres above a gold surface with nanogap," J. Chem. Phys. 125, 174703 (2006).
[CrossRef] [PubMed]

J. Phys. Chem. (1)

T. Okamoto and I. Yamaguchi, "Optical absorption study of the surface plasmon resonance in gold nanoparticles immobilized onto a gold substrate by a self-assembly technique," J. Phys. Chem. 107, 10321-10324 (2003).
[CrossRef]

Jpn. J. Appl. Phys. (1)

K. Tsuboi, K. Seki, Y. Ouchi, K. Fujita, and K. Kajikawa, "Formation of a merocyanine self-assembled monolayer and its nonlinear optical properties probed by second-harmonic generation and surface plasmon resonance," Jpn. J. Appl. Phys. 42, 607-613 (2003).
[CrossRef]

Langmuir (1)

K. Fujita, M. Hara, H. Sasabe, W. Knoll, K. Tsuboi, K. Kajikawa, K. Seki, and Y. Ouchi, "Solvatchromism of a merocyanine derivative in a self-assembled monolayer on gold substrate," Langmuir 14, 7456-7462 (1998).
[CrossRef]

Mol. BioSystems (1)

S. Watanabe, K. Usui, K.-Y. Tomizaki, K. Kajikawa, and H. Mihara, "Anomalous reflection of gold applicable for a practical protein-detecting chip platform," Mol. BioSystems 1, 363-365 (2005).
[CrossRef]

Opt. Lett. (1)

Phys. Rev. B (1)

S. Abe and K. Kajikawa, "Linear and nonlinear optical properties of gold nanoparticles immobilized on metallic surface," Phys. Rev. B 74, 035416 (2006).
[CrossRef]

Sens. Actuators B (7)

M. Watanabe and K. Kajikawa, "An optical fiber biosensor based on anonymous reflection of gold," Sens. Actuators B 86, 126-130 (2003).
[CrossRef]

J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
[CrossRef]

M. Himmelhaus and H. Takei, "Cap shaped gold nanoparticles for an optical biosensor," Sens. Actuators B 63, 24-30 (1999).
[CrossRef]

Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
[CrossRef]

I. Mannelli, V. Courtois, P. Lecaruyer, G. Roger, M. C. Millot, M. Goossens, and M. Canva, "Surface plasmon resonance imaging (SPRI) system and real-time monitoring of DNA biochip for human genetic mutation diagnosis of DNA amplified samples," Sens. Actuators B 119, 583-591 (2006).
[CrossRef]

Y. Xinglong, W. Dongsheng, W. Dingxin, O. J. Hua, Y. Zibo, D. Yonggui, and Z. Xinsheng, "Micro-array detection system for gene expression products based on surface plasmon resonance imaging," Sens. Actuators B 91, 133-137 (2003).
[CrossRef]

N. Bassil, E. Maillart, M. Canva, Y. Levy, M.-C. Millot, S. Pissard, R. Narwa, and M. Goossens, "One hundred spot parallel monitoring of DNA interactions by SPR imaging of polymer-functionalized surfaces applied to the detection of cystic fibrosis mutations," Sens. Actuators B 94, 313-323 (2003).
[CrossRef]

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Figures (7)

Fig. 1
Fig. 1

Multichannel LSP biosensor platform. The sensing spots are composed of SIGNs above a gold thin film, in which the nanogap is supported by merocyanine SAMs.

Fig. 2
Fig. 2

Optical setup for imaging of a biosensing array: (a) reflection detection, (b) SH measurement.

Fig. 3
Fig. 3

Real-time measurement of the binding process of avidin to a biotin-labeled gold surface.

Fig. 4
Fig. 4

(a) SH image of the biosensing array illuminated at a wavelength of 750 n m (nonspecific binding of avidin to SIGNs). Avidin was bound on spots A1, B2, and C3. (b) SH intensity profile across the A line.

Fig. 5
Fig. 5

(a) SH image of the biosensing array illuminated at a wavelength of 750 n m (specific binding of avidin to biotin-labeled SIGNs). Avidin was bound on spots B3, C2, and D3. (b) SH intensity profile across the B line.

Fig. 6
Fig. 6

Blue-ray reflection image of the biosensing array (specific binding of avidin to biotin-labeled SIGNs). (b) Blue-ray reflection profile across the B line.

Fig. 7
Fig. 7

Reflection absorption spectrum and SHG spectrum of the SIGNs above a gold surface.

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