We review integrated optical sensors for functional brain imaging, localized index-of-refraction sensing as part of a lab-on-a-chip, and in vivo continuous monitoring of tumor and cancer stem cells. We present semiconductor-based sensors and imaging systems for these applications. Measured intrinsic optical signals and tissue optics simulations indicate the need for high dynamic range and low dark-current neural sensors. Simulated and measured reflectance spectra from our guided resonance filter demonstrate the capability for index-of-refraction sensing on cellular scales, compatible with integrated biosensors. Finally, we characterized a thermally evaporated emission filter that can be used to improve sensitivity for in vivo fluorescence sensing.
© 2007 Optical Society of AmericaFull Article | PDF Article
John R. Tucker, Johnathon L. Baque, Yah Leng Lim, Andrei V. Zvyagin, and Aleksandar D. Rakić
Appl. Opt. 46(25) 6237-6246 (2007)
Bei Wang, Stephen P. Povoski, Xianhua Cao, Duxin Sun, and Ronald X. Xu
Appl. Opt. 47(16) 3053-3063 (2008)
Antonios V. Giannopoulos, Ansas M. Kasten, Christopher M. Long, Chen Chen, and Kent D. Choquette
Appl. Opt. 47(25) 4555-4559 (2008)