Abstract
We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.
© 2006 Optical Society of America
Full Article | PDF ArticleMore Like This
Vladimir M. Turzhitsky, Andrew J. Gomes, Young L. Kim, Yang Liu, Alexey Kromine, Jeremy D. Rogers, Mohammed Jameel, Hemant K. Roy, and Vadim Backman
Appl. Opt. 47(32) 6046-6057 (2008)
Hsing-Wen Wang, Jeng-Kai Jiang, Chi-Hung Lin, Jen-Kou Lin, Guang-Jie Huang, and Jia-Sin Yu
Opt. Express 17(4) 2805-2817 (2009)
George Zonios, Lev T. Perelman, Vadim Backman, Ramasamy Manoharan, Maryann Fitzmaurice, Jacques Van Dam, and Michael S. Feld
Appl. Opt. 38(31) 6628-6637 (1999)