Abstract

Hyperspectral interferometric microscopy uses a unique combination of optics and algorithm design to extract information. Local brain activity rapidly changes local blood flow and red blood cell concentration (absorption) and oxygenation (color). We demonstrate that brain activity evoked during whisker stimulation can be detected with hyperspectral interferometric microscopy to identify the active whisker-barrel cortex in the rat brain. Information about constituent components is extracted across the entire spectral band. Algorithms can be flexibly optimized to discover, detect, quantify, and visualize a wide range of significant biological events, including changes relevant to the diagnosis and treatment of disease.

© 2006 Optical Society of America

PDF Article
More Like This
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation

Andrew K. Dunn, Anna Devor, Hayrunnisa Bolay, Mark L. Andermann, Michael A. Moskowitz, Anders M. Dale, and David A. Boas
Opt. Lett. 28(1) 28-30 (2003)

Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography

Peijun Tang, Yuandong Li, Adiya Rakymzhan, Zhiying Xie, and Ruikang K. Wang
Biomed. Opt. Express 11(2) 699-710 (2020)

Hemodynamic responses in rat brain during transcranial direct current stimulation: a functional near-infrared spectroscopy study

Chang-Hee Han, Hyuna Song, Yong-Guk Kang, Beop-Min Kim, and Chang-Hwan Im
Biomed. Opt. Express 5(6) 1812-1821 (2014)

View More...

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription