Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Abstract

Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

© 2005 Optical Society of America

Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis

R.I. Siphanto, K.K. Thumma, R.G.M. Kolkman, T.G. van Leeuwen, F.F.M. de Mul, J.W. van Neck, L.N.A. van Adrichem, and W. Steenbergen
Opt. Express 13(1) 89-95 (2005)

Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent

Xueding Wang, Geng Ku, Malgorzata A. Wegiel, Darryl J. Bornhop, George Stoica, and Lihong V. Wang
Opt. Lett. 29(7) 730-732 (2004)

Noninvasive in vivo monitoring of collagenase induced intracerebral hemorrhage by photoacoustic tomography

Dan Wu, Jinge Yang, Guang Zhang, and Huabei Jiang
Biomed. Opt. Express 8(4) 2276-2286 (2017)

Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent

Geng Ku and Lihong V. Wang
Opt. Lett. 30(5) 507-509 (2005)

Fast full-view photoacoustic imaging by combined scanning with a linear transducer array

Diwu Yang, Da Xing, Sihua Yang, and Liangzhong Xiang
Opt. Express 15(23) 15566-15575 (2007)